Reductive cross-coupling of aryl chlorides or electron-rich aryl bromides with benzyl chlorides remains a significant challenge, presumably due to the lower reactivity of aryl chlorides or electron-rich aryl bromides with the nickel catalyst compared with aryl iodides. Here, the authors present Ni-catalyzed enantioselective electroreductive cross-coupling of benzyl chlorides with aryl halides, yielding chiral 1,1-diaryl compounds with good to excellent enantioselectivity, without resorting to heterogeneous metal reductants or sacrificial anodes.
- Yun-Zhao Wang
- Bing Sun
- Tian-Sheng Mei
