Nature Search

Elevated nitric oxide during colitis restrains GM-CSF production in ILC3 cells via suppressing an AhR-Cyp4f13-NF-κB axis

Metabolic processes lead to the production of bioactive gases, such as nitric oxide, which may play roles in the gut immune homeostasis. Here authors show that genomic deletion of Nos2 in mice aggravates colitis in experimental models via an Aryl-Hydrocarbon-Receptor-mediated pathway in type 3 innate lymphoid cells.

Xingyu Zhao
Jun Li
Chao Zhong
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-18
SR-A3 suppresses AKT activation to protect against MAFLD by inhibiting XIAP-mediated PTEN degradation

Scavenger receptor class A member 3 (SR-A3) is implicated in metabolic diseases, but its relationship with MAFLD remains unclear. Here, the authors show that SR-A3 is an important modulator of hepatic energy metabolism and is a potential therapeutic target against MAFLD.

Pingping Lai
Guolin Miao
Xunde Xian
ResearchOpen Access11 Mar 2025
Nature Communications

Volume: 16, P: 1-18
Selective C-H trifluoromethoxylation of (hetero)arenes as limiting reagent

Selective C-H trifluoromethoxylation of pyridines remains a formidable synthetic challenge. Here, the authors report a silver-mediated late-stage C-H trifluoromethoxylation of arenes and heteroarenes as limiting reagents with trifluoromethoxide anion.

Zhijie Deng
Mingxin Zhao
Pingping Tang
ResearchOpen Access22 May 2020
Nature Communications

Volume: 11, P: 1-9
Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

The SARS-CoV-2 Delta variant has spread rapidly worldwide. Here, the authors characterise a single chain of transmission of Delta in China, and find evidence that it is more infectious and replicates faster during early infection compared to early pandemic lineages.

Baisheng Li
Aiping Deng
Jing Lu
ResearchOpen Access24 Jan 2022
Nature Communications

Volume: 13, P: 1-9
Publisher Correction: Evolutionary transcriptomics of metazoan biphasic life cycle supports a single intercalation origin of metazoan larvae

Jing Wang
Lingling Zhang
Shi Wang
Amendments and Corrections20 Apr 2020
Nature Ecology & Evolution

Volume: 4, P: 766
Effect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controlled Trial

This randomized trial assessed the effectiveness and safety of single blastocyst transfer vs single cleavage-stage embryo transfer among women with good prognosis. Here, the authors show improved cumulative live birth rates and relatively unfavorable perinatal outcomes after blastocyst transfer.

Xiang Ma
Jing Wang
Jiayin Liu
ResearchOpen Access05 Sept 2024
Nature Communications

Volume: 15, P: 1-13
Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling ___domain of human Sonic hedgehog (ShhNp) at a 4:2 stoichiometric ratio.

Hongwu Qian
Pingping Cao
Xin Gong
ResearchOpen Access24 May 2019
Nature Communications

Volume: 10, P: 1-9
Evolutionary transcriptomics of metazoan biphasic life cycle supports a single intercalation origin of metazoan larvae

Evolutionary analysis of transcriptomes across Metazoa supports a scenario of ancestral adult stages and a single intercalation event at the origin of larvae.

Jing Wang
Lingling Zhang
Shi Wang
Research16 Mar 2020
Nature Ecology & Evolution

Volume: 4, P: 725-736
Insulin induces insulin receptor degradation in the liver through EphB4

The tyrosine kinase receptor EphB4 is shown to interact with the insulin receptor to facilitate its endocytosis and degradation, thereby decreasing insulin signaling and promoting insulin resistance.

Xingfeng Liu
Kai Wang
Pingping Li
Research21 Sept 2022
Nature Metabolism

Volume: 4, P: 1202-1213
Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore

A phenylboronic acid-modified hetero-octameric Mycobacterium smegmatis porin A nanopore can directly distinguish 11 types of nucleoside monophosphates with a 0.996 accuracy.

Yuqin Wang
Shanyu Zhang
Shuo Huang
Research18 Jul 2022
Nature Nanotechnology

Volume: 17, P: 976-983
Trimethylamine N-oxide impairs β-cell function and glucose tolerance

β-Cell dysfunction is a hallmark of type 2 diabetes. Here, the authors show that trimethylamine N-oxide (TMAO (a microbiota metabolite)) induces β-cell dysfunction and type 2 diabetes in mice through NLRP3 inflammasome activation and calcium transients.

Lijuan Kong
Qijin Zhao
Pingping Li
ResearchOpen Access21 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Addressing the quantitative conversion bottleneck in single-atom catalysis

The practical application of single atom catalyst (SAC) in liquid-phase heterogeneous catalysis is hampered by the productivity bottleneck as well as catalyst leaching. Here, a bench-top, fast-flow reactor integrated with Pt1-MoS2 SAC was fabricated for continuous production of multifunctional anilines (28 examples) at a record productivity of 5.8 g h-1.

Zhongxin Chen
Jingting Song
Kian Ping Loh
ResearchOpen Access19 May 2022
Nature Communications

Volume: 13, P: 1-8
Telomere dysfunction activates YAP1 to drive tissue inflammation

How telomere dysfunction is directly linked to inflammation in humans is currently unclear. Here the authors reveal that telomere dysfunction drives activation of the YAP1 transcription factor, up-regulating the pro inflammatory factor, pro-IL-18 thus revealing a link between telomere dysfunction and initiation of intestinal inflammation.

Deepavali Chakravarti
Baoli Hu
Ronald A. DePinho
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-13
Numerical simulation of micro crack evolution and failure modes of limestone under uniaxial multi-level cyclic loading

Yanjun Yin
Jianhua Hu
Pingping Zeng
ResearchOpen Access13 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L.

Sequencing of haploid sugarcane, Saccharum spontaneum, allows assembly of a prototypical version of the sugarcane chromosome set. This new reference genome will serve as a resource to accelerate sugarcane improvement.

Jisen Zhang
Xingtan Zhang
Ray Ming
ResearchOpen Access08 Oct 2018
Nature Genetics

Volume: 50, P: 1565-1573
Porous metal-metalloporphyrin gel as catalytic binding pocket for highly efficient synergistic catalysis

Synergistic catalysis occurring in an enzyme pocket shows enhanced performance through supramolecular recognition and flexibility. Here the authors design an enzyme-mimic strategy to develop a Co(II) metal-metalloporphyrin gel with excellent synergistically catalytic performance and chemo/stereo selectivity.

Weijie Zhang
James J. Dynes
Shengqian Ma
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-8
An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy

Alvarez and colleagues develop a bispecific anti-PD-1–GITR-L agonist that activates T cells via a mechanism distinct from those found with individual PD-1 and GITR-L agonists and demonstrate its antitumor activity in mice and nonhuman primates.

Sarah Chan
Nicole Belmar
Hamsell M. Alvarez
ResearchOpen Access07 Mar 2022
Nature Cancer

Volume: 3, P: 337-354
Endothelial senescence induced by PAI-1 promotes endometrial fibrosis

Jing Wu
Jie Wang
Guangfeng Zhao
ResearchOpen Access06 Mar 2025
Cell Death Discovery

Volume: 11, P: 1-11
Serum midkine as a surrogate biomarker for metastatic prediction in differentiated thyroid cancer patients with positive thyroglobulin antibody

Qiang Jia
Zhaowei Meng
Chunmei Zhang
ResearchOpen Access27 Feb 2017
Scientific Reports

Volume: 7, P: 1-7
Multiple-factor analysis of the first radioactive iodine therapy in post-operative patients with differentiated thyroid cancer for achieving a disease-free status

Na Liu
Zhaowei Meng
Sen Wang
ResearchOpen Access10 Oct 2016
Scientific Reports

Volume: 6, P: 1-7
Superior Adsorption and Regenerable Dye Adsorbent Based on Flower-Like Molybdenum Disulfide Nanostructure

Sancan Han
Kerui Liu
Yufang Zhu
ResearchOpen Access08 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Publisher Correction: Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L

Jisen Zhang
Xingtan Zhang
Ray Ming
Amendments and Corrections13 Nov 2018
Nature Genetics

Volume: 50, P: 1754
The DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemia

Guangming Wang
Wenjun Zhang
Aibin Liang
ResearchOpen Access26 Apr 2024
Oncogene

Volume: 43, P: 1900-1916
Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation

Fuwen Wei, Jun Wang and colleagues report whole-genome sequencing of 34 wild giant pandas. Their population genetic analysis provides insights into demographic history and local adaptation.

Shancen Zhao
Pingping Zheng
Fuwen Wei
Research16 Dec 2012
Nature Genetics

Volume: 45, P: 67-71
Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs

Tumor associated macrophages (TAMs) promote cancer progression. Here, the author show that caspase-1 promotes TAMs differentiation by attenuating medium-chain acyl-CoA dehydrogenase activity and that inhibition of this axis results in suppression of tumour growth in a transgenic mouse model of breast cancer.

Zhiyuan Niu
Qian Shi
Pingping Shen
ResearchOpen Access03 Oct 2017
Nature Communications

Volume: 8, P: 1-18
The prognostic value of cytotoxic T-lymphocyte antigen 4 in cancers: a systematic review and meta-analysis

Pingping Hu
Qiqi Liu
Jiandong Zhang
ResearchOpen Access17 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
Association between liver function and metabolic syndrome in Chinese men and women

Sen Wang
Jie Zhang
Qiyu Jia
ResearchOpen Access20 Mar 2017
Scientific Reports

Volume: 7, P: 1-9
Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

In an inducible mouse model of pancreatic ductal adenocarcinoma, the signalling defect that underlies 90% of these tumours causes increased cell-surface expression of syndecan 1, leading to misregulation of macropinocytosis, and linking the defective signalling with nutrient-salvage pathways.

Wantong Yao
Johnathon L. Rose
Giulio F. Draetta
Research27 Mar 2019
Nature

Volume: 568, P: 410-414
Serial sequencing of isolength RAD tags for cost-efficient genome-wide profiling of genetic and epigenetic variations

This protocol uses restriction enzymes to produce isolength tags that are concatenated and sequenced to allow genome-wide genotyping and quantification of DNA methylation levels.

Shi Wang
Pingping Liu
Zhenmin Bao
Protocols06 Oct 2016
Nature Protocols

Volume: 11, P: 2189-2200
Tracking the hologenome dynamics in aquatic invertebrates by the holo-2bRAD approach

Holo-2bRAD allows cost-effective and stable tracking of hologenome dynamics in marine invertebrates, also for difficult samples. It was used to identify two host SNPs and a change of core microbial species in mass mortality events of bivalve larvae.

Cen Ma
Chang Xu
Pingping Liu
ResearchOpen Access07 Jul 2024
Communications Biology

Volume: 7, P: 1-14
Strigolactones positively regulate abscisic acid-dependent heat and cold tolerance in tomato

Cheng Chi
Xuechen Xu
Jingquan Yu
ResearchOpen Access01 Nov 2021
Horticulture Research

Volume: 8, P: 1-15
A new isolation device for shortening gene flow distance in small-scale transgenic maize breeding

Lili Zhang
Shanshan Huo
Anping Guo
ResearchOpen Access25 Sept 2020
Scientific Reports

Volume: 10, P: 1-10
Comprehensive Mass Spectral Libraries of Human Thyroid Tissues and Cells

Lu Li
Wenhao Jiang
Yaoting Sun
ResearchOpen Access28 Dec 2024
Scientific Data

Volume: 11, P: 1-10
Xuefu Zhuyu decoction, a traditional Chinese medicine, provides neuroprotection in a rat model of traumatic brain injury via an anti-inflammatory pathway

Zhihua Xing
Zian Xia
Yang Wang
ResearchOpen Access28 Jan 2016
Scientific Reports

Volume: 6, P: 1-14
Rhein and rhubarb similarly protect the blood-brain barrier after experimental traumatic brain injury via gp91^phox subunit of NADPH oxidase/ROS/ERK/MMP-9 signaling pathway

Yang Wang
Xuegong Fan
Xi Huang
ResearchOpen Access30 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Correction: Corrigendum: Superior Adsorption and Regenerable Dye Adsorbent Based on Flower-Like Molybdenum Disulfide Nanostructure

Sancan Han
Kerui Liu
Yufang Zhu
Amendments and CorrectionsOpen Access03 Aug 2017
Scientific Reports

Volume: 7, P: 1
Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions

Nanfei Yang
Yuxin Wang
Pingping Shen
ResearchOpen Access03 Nov 2022
Cell Death & Differentiation

Volume: 30, P: 766-778
Optimization and control of the light environment for greenhouse crop production

Pingping Xin
Bin Li
Jin Hu
ResearchOpen Access17 Jun 2019
Scientific Reports

Volume: 9, P: 1-13
The autism-related gene SNRPN regulates cortical and spine development via controlling nuclear receptor Nr4a1

Huiping Li
Pingping Zhao
Xiu Xu
ResearchOpen Access19 Jul 2016
Scientific Reports

Volume: 6, P: 1-10
Efficient generation of FVII gene knockout mice using CRISPR/Cas9 nuclease and truncated guided RNAs

Liyou An
Yeshu Hu
Fuliang Du
ResearchOpen Access03 May 2016
Scientific Reports

Volume: 6, P: 1-9
Novel conditioning regimen in upfront autologous stem cell transplantation in high-risk DLBCL

Jiexian Ma
Shunrong Sun
Yanhui Xie
Correspondence25 Jul 2022
Bone Marrow Transplantation

Volume: 57, P: 1612-1614
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

Xi Chen
Yi Ba
Chen-Yu Zhang
Research02 Sept 2008
Cell Research

Volume: 18, P: 997-1006

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