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Showing 1–7 of 7 results
Advanced filters: Author: Pinhong Chen Clear advanced filters
  • Asymmetric dioxygenation of alkenes is an attractive concept to synthesize enantioenriched diols, but the performance in the case of terminal alkenes is low with current methods. Now, this has been addressed by an asymmetric oxypalladation process that provides access to enantioenriched 1,2-diols, enabled by the chiral 6-modified pyridinyl oxazoline ligand.

    • Bing Tian
    • Pinhong Chen
    • Guosheng Liu
    Research
    Nature Catalysis
    Volume: 4, P: 172-179
  • The efficiency of enantioselective sp3 C–H bond oxidation using small synthetic catalysts is usually limited. Now a catalytic system involving a Cu(II)-bound tert-butoxy radical for site-selective C–H bond cleavage achieves allylic and propargylic sp3 C–H oxidation with the C–H substrates as the limiting reagent.

    • Honggang Zhang
    • Yibo Zhou
    • Guosheng Liu
    Research
    Nature Catalysis
    Volume: 8, P: 58-66
  • Functionalization of unsymmetrical internal alkenes usually takes place with low regioselectivity, giving a mixture of isomers. Now, a highly regio- and enantioselective remote 1,n-dioxygenation of internal alkenes using a palladium catalyst has been developed for the synthesis of chiral 1,n-diols. Regioselectivity tuning was demonstrated by altering the rate-determining step, enabled by the phenyl-substituted Pyox ligand.

    • Xiaonan Li
    • Tilong Yang
    • Guosheng Liu
    Research
    Nature Chemistry
    Volume: 15, P: 862-871
  • The hydrohalogenation of alkenes generally forms branched alkyl halides. Now, a palladium-catalysed method has been developed for the remote hydrohalogenation of internal and terminal alkenes, enabling the efficient synthesis of linear alkyl halides. The method uses an engineered Pyox ligand with a hydroxy group, which is essential for accelerating the oxidative halogenation.

    • Xiang Li
    • Jianbo Jin
    • Guosheng Liu
    Research
    Nature Chemistry
    Volume: 14, P: 425-432
  • Asymmetric cyanation reactions promoted by chiral copper catalysts via a radical relay process are discussed in this Perspective. In particular, we outline the mechanisms of carbon radical formation and subsequent asymmetric radical cyanation reactions.

    • Fei Wang
    • Pinhong Chen
    • Guosheng Liu
    Reviews
    Nature Synthesis
    Volume: 1, P: 107-116