Search

Coffee has been associated with reduced colorectal cancer incidence. Here, the authors show that caffeine inhibits the kynurenine pathway, boosting CD8⁺ T-cell immunogenic activity, which impairs colorectal cancer progression and enhances immunotherapy response.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Vacuolation has been shown to be possible in super-stoichiometric ratios of the assembling component, but this is not so relevant to biological systems. Here, the authors report the introduction of small, charged motifs for induction of transient vacuolation.

An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as air pollution and passive smoking.

Neural circuit mechanisms that regulate the panic-like defensive state are not fully understood. Using a robot-based experimental paradigm, the authors identify Cbln2-expressing (Cbln2+) neurons in the mouse posterior hypothalamic nucleus (PHN) as a key neuronal population essential for the induction of panic-like defensive state.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Legionella effector LnaB, a recently identified actin-activated AMPylase, mediates phosphoryl-AMPylation in a yet-unknown manner. Here the authors unveil a two-step catalytic process involving dual ATPase–AMPylase activity based on structural studies, providing a biochemical basis for AMPylation.

It has long been believed that topological phases are solely determined by their lattice structures. Here, the authors report the observation of cavity-tunable topological phases of polaritons by modifying the surrounding photonic environment without altering the lattice structure.

Dendritic cell-based therapies have been exploited as immunotherapeutic approaches for cancer treatment. Here the authors report a platform integrating antigen-capturing nanoparticles and type 1 conventional dendritic cells for in situ cancer immunization, promoting anti-tumor immunity in preclinical models.

A versatile nano-adaptor is used to construct multi-specific nano-antibodies for treatment of tumours in mice.

Chronic wounds typically exhibit dynamic variations within the complex wound microenvironment over time. Here, Cheng et al. develop a microenvironment-feedback hydrogel to achieve homeostatic wound pH and blood glucose levels to accelerate repair of diabetic chronic wounds.

Mitochondria play a key role in cellular metabolism. Here, authors develop a Variational Autoencoder to design novel mitochondrial targeting sequences, validating them across several eukaryotic organisms and demonstrating their utility in metabolic engineering and protein delivery.

Cell-cell communication often induces crosstalk between multiple pathways through shared regulators that are often overlooked. Here, the authors present SigXTalk, a hypergraph-based machine learning method that quantifies cell-cell communication crosstalk from single-cell RNA-seq data.

Neural networks fundamentally dictate function. Here, the authors show thirteen uniquely connected neuron populations within the anterior thalamic nuclei, suggesting multiple parallel subnetworks support its emotional and cognitive functions.

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

Formation of a stable self-assembled monolayer for high-efficiency perovskite solar cells remains a challenge. Here uniform and stable SAM anchoring is achieved on a hydroxylated indium tin oxide surface, leading to highly efficient and stable perovskite solar cells.

Pt-based alloy cathode catalysts in proton exchange membrane fuel cells face persistent challenges, including rapid oxidation and loss of transition metal/Pt. Here, the authors report a covalentization concept in intermetallic L1₀-structure Pt-based alloys to boost stability in fuel cells.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The mechanisms underlying the invasiveness and aggressiveness of pituitary neuroendocrine tumours (PitNETs) remain poorly understood. Here, the authors perform single-cell RNA sequencing and spatial transcriptomics to characterise the tumour microenvironment of PitNETs and identify potential therapeutic targets.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

This work demonstrates an efficient electrochemical exfoliation approach to achieve high recovery rate for few-layered halogenated MXenes by leveraging gaseous propylene molecules as ‘physical scissors’, to enable advanced tribovoltaic nanogenerators.

Land plants diverged from streptophyte algae around 460 million years ago. Marine Charophyceae fossils from the Upper Ordovician confirm that morphological innovations key to the evolution of terrestrial flora predate the emergence of land plants.

The connection between plasma proteomic and brain structure remains unclear. Here, the authors establish a comprehensive atlas of the patterns of associations between microscale proteome and brain structure, and demonstrate their potential value for studying brain disorders.

The mechanisms whereby METH yields strong addiction potential is not fully understood. Here, authors show that METH may impair the function of the endogenous OXT system, particularly the PVN^OXT-NAc core pathway, suggesting OXT-based therapies for METH use disorder (MUD).

Dual targeting of BRAF and MAPK signaling in the BRAF v600E mutant colorectal cancer patients has shown limited efficacy in clinical studies. Here, the authors identify PLK1 inhibition as synthetic lethal with dual BRAF and EGFR inhibition due to loss of ferroptosis inhibition via a PLK1-CBX8-GPX4 signaling axis in preclinical models of colorectal cancer.

Sphingosine-1-phosphate receptor 1 (S1PR1) is a drug target for inflammatory bowel disease (IBD), impacting immune cell movement, but current treatments carry immunosuppression risks. Here, the authors show that a Gi-biased S1PR1 agonist, SAR247799, protects the endothelial barrier in IBD models without affecting immune cell egress, offering a potential new treatment strategy.

Wei et al. found that the nuclear E3 ligase ubiquitin protein ligase E3 component n-recognin 5 (UBR5) ubiquitinated VGLL4 at Lys61 for its degradation, which permits Hippo–YAP signaling for the development of liver biliary system in mice and multiple cancers in humans.

Continuous shape morphing for small robots can offer advantages, but it is difficult to perform tasks if they are not stiff enough. Xu et al. present here a design combining liquid crystal elastomers and shape memory polymers to lock morphable elements in place.

Despite the growing demand for optically active boron dipyrromethenes (BODIPYs), which are useful in live cell imaging, photodynamic therapy, and fluorescent materials science, the synthesis of chiral 3-amino-BODIPYs remains a challenge. Herein, the authors report the first synthesis of boron-stereogenic 3-amino-BODIPYs via a palladium-catalyzed desymmetric C–N cross-couplings.

The bacterial pathogen Legionella pneumophila is known to regulate a wide spectrum of host processes using its Dot/Icm effectors. In this work, He et al. provide insight into L. pneumophila regulation of ATP level in host cells.

This study demonstrated that amplified ethylene signaling impairs gravitropic growth of rice roots by affecting root cap stability and OsPIN2 polar localization, whereas mechanosensing-induced calcium signaling antagonizes ethylene signaling to safeguard gravitropism.

Chemical modifications in DNA enable hidden messages for secure data transmission. Here, authors develop DeepSME, a nanopore sequencing and deep-learning framework that conceals data into DNA using 5-hydroxymethylcytosine and enables single-molecule private communication.

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by rapid motor neuron (MN) degeneration, with unclear causes in sporadic cases. Here, the authors showed that N6-methyladenosine (m6A) RNA modification drives ALS, and restoring it may protect MNs and lessen motor issues.

The quality of the Li–electrolyte interface is key to solid-state battery performance, especially at low pressure. Here, authors use operando electron microscopy to reveal how Li-Mg alloy anodes improve interfacial contact and low-pressure cycling stability by suppressing void formation.

The single-cell and spatial transcriptomic atlases shed light on the molecular characteristics and spatial distribution of various ovarian cell types during folliculogenesis, and luteinization following ovulation.

The authors study CsV₃Sb₅ by nuclear quadrupole resonance. At ambient pressure, there are two superconducting gaps with line nodes in the smaller one. For pressures above P_c ~ 1.85 GPa, where the charge-density wave phase is completely suppressed, they observe fully-gapped superconductivity with broken rotational symmetry.

Zinc gluconate in oral supplements associates with plasma proteins to form renal-tumour-accumulating ZnO nanoparticles, which have antitumoural immune activity and can also be used for the delivery of chemotherapeutic agents.

Realization of a gyromagnetic double-zero-index metamaterial results in unconventional optical and topological properties, suitable to be used for the generation of light pulses shaped as a vortex both in time and space.