Search

Hypervirulent Klebsiella pneumoniae (hvKp) is a significant cause of severe community-acquired infection, primarily in Asia. Here, the authors characterise the genetic profile, phylogenetic structure, and plasmid features of hvKp in Vietnam.

Despite exhibiting ferroelectric features, SrTiO₃ fails to display long-range polar order at low temperatures due to quantum fluctuations. An ultrafast X-ray diffraction experiment now probes polar dynamics of this material at the nanometre scale.

In CHIP, somatic mutations in a hematopoietic stem cell lead to a clonal subpopulation of blood cells. Here, the authors perform a CHIP meta-EWAS to establish its epigenetic features and age-related outcomes.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

The posterior hippocampal tail is an important seizure node in humans and may be a promising interventional target in epilepsy.

Recently, rich condensed matter physics has emerged from the interplay between band topology and magnetic order. Here, the authors characterize the magnetic Weyl semimetal CeAlGe and find evidence for the role of Weyl fermions in stabilizing the magnetic order above the local transition temperature.

Traditional systematic anti-seizure treatments alter brain-wide activity and often carry significant side effects. The authors engineered an inhibitory, acetylcholine receptor-based, chemogenetic tool to suppress targeted neurons, enabling control of chronic seizures in mice.

Natural disasters can trigger conflictive behaviour among affected individuals. Now, research based on survey experiments with Syrian and Iraqi refugees shows how people behave altruistically after experiencing drought, but only towards ingroup members.

Recent prior influenza A infection is associated with elevated hemagglutinin-inhibiting antibody responses and greater breadth of reactivity to influenza strains following vaccination, suggesting that infection history boosts vaccine responses.

Genomic analysis of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients identifies the transmission dynamics of Mtb in Vietnam including frequent transmission of Beijing lineage and positive selection for EsxW Beijing variant.

Understanding transformations of non-equilibrium materials is a key open scientific question. Here the pathway by which different polar supertextures undergo dynamical correlations and collectively transform into a metastable supercrystal state is revealed experimentally and theoretically over seven orders of magnitude timescale.

Nguyen et al. take a fresh look at Tesla’s concept of an asymmetric fluidic conduit. They show that for alternating flow at high frequencies the device can almost be operated as a diode, enabled by a transition to turbulent-like flow at rather low Reynolds numbers.

Theories predict a large thermopower and a quantized thermoelectric Hall conductivity in topological semimetals. Here, the authors observe an ultrahigh longitudinal thermopower and a giant power factor attributed to the quantized thermoelectric Hall effect in a Weyl semimetal TaP.

We report the observation of narrowband terahertz emission from a quasi-one-dimensional charge-density-wave insulator, (TaSe₄)₂I. The origin of the emitted radiation is interpreted as a phason that obtains mass due to the long-range Coulomb interaction.

The interplay between charge density wave states in emerging kagome superconductors is a topic of ongoing debate. Here, the authors unveil the out-of-equilibrium competition between two coexisting charge density waves in CsV₃Sb₅ by harnessing time-resolved X-ray diffraction.

Surveying next generation sequencing capabilities in 13 Asian countries identifies challenges to be met for improved implementation, pathogen surveillance and integration into public health decision-making.

A series of enzymes that catalyse the formation of strained peptide cyclophanes through a stereospecific C(sp²)–C(sp³) bond have been identified. Crosslinking occurs on three-residue motifs that include tryptophan or phenylalanine to form indole- or phenyl-bridged cyclophanes. These enzymes are widely distributed in nature and represent promising tools for peptide biotechnology.

By capitalizing on copy number variation, Wu and his colleagues offer an approach for detecting cellular chimerism with fluorescent in situ hybridization probes that target polymorphic deletion loci. These probes can determine the fate of donor cells in situ, irrespective of gender, and should prove useful in understanding the dynamics of cellular chimerism after solid organ, bone marrow and hematopoietic stem cell transplantation.

Understanding how the immune system’s functionality declines with age is crucial for addressing aging-related health issues. Here, the authors demonstrate that activating TLR5 in the mucosal layer can significantly improve healthspan and longevity, suggesting a novel approach for aging interventions.

The pathobiology of heart failure (HF) is incompletely understood. The authors identify 37 circulating proteins and 5 protein modules associated with HF risk, with several demonstrating causal effects on HF, risk factors, or cardiac dysfunction by Mendelian randomization analysis.

IL6 expression in the bone marrow is associated with reduced survival in paediatric AML. Here, the authors used RNA-seq to identify treatment resistance-associated co-occurring inflammatory signalling in leukemic cells.

Natural rubber (NR) and cellulose nanofibers (CNF) are promising biopolymers for developing sustainable materials. NR offers excellent elasticity and resilience, while CNF provides high mechanical strength for reinforcement. Due to polarity differences, NR’s compatibility with CNF is limited. To address this, graft copolymerization of styrene/acrylonitrile onto deproteinized natural rubber (DPNR) was performed, improving polarity, thermal stability, and mechanical strength. CNF were ultrasonically dispersed in latex to create reinforced composites. The resulting materials exhibit superior properties, making them suitable for advanced sustainable applications.

People may choose or be forced to relocate due to climate change. Here the authors show that urban residents in Vietnam and Kenya view climate conditions as a legitimate reason for migration from rural to urban areas, but environmental migrants are not seen as more deserving than economic migrants.

Clonal hematopoiesis, often caused by mutations in DNMT3A and TET2, is associated with blood cancer and coronary artery disease. Here, the authors conduct an epigenome-wide association study, finding that clonal hematopoiesis caused by DNMT3A vs. TET2 mutations has directionally opposing changes in DNA methylation profiles, with both promoting stem cell self-renewal.

Laser ablation is a phenomenon where the fundamental research directly intersects with practical relevance for industrial applications, yet probing the highly nonequilibrium phase decomposition triggered by laser excitation is still a challenge. This study provides unique insights into the dynamics of nanoscale phase decomposition in laser ablation of thin gold films by combining time-resolved femtosecond X-ray probing with large-scale atomistic modeling.

Avian influenza viruses can mutate and become infectious to humans, sometimes causing high mortality. Here, Fan et al.identify three mutations in viral protein PB2 that affect virulence in mammalian hosts.