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Proteome profiling of plasma samples in human pan-cancer cohorts reveals patterns of biomarkers for diagnosis.

NASA’s Cassini probe will go where no spacecraft has gone before — between a planet and its rings.

Complex traits present challenges for gene mapping and molecular characterization. Here, the authors develop a 16-generation intercross line of chickens to explore the genetic architecture of complex traits in chicken.

‘Small cell lung cancers do not respond well to immune checkpoint blockade therapy, due to the poor recruitment of CD8 + T cells to the tumours. Here authors show that via combining radiotherapy, PARP inhibitors and anti-PD-L1 treatments, T cell infiltration and function could be improved via mechanisms that increase the chemo-attractants CCL5 and CXCL10.

Analysis of ancient DNA, stable isotope data and archaeological evidence from the Fujia archaeological site in eastern China suggests it was populated by a matrilineal Neolithic community between 2750 and 2500 bc.

Broad and potent neutralizing antibodies to SARS-CoV-2 variants can be efficiently identified via accurate deep-mutational-scanning-based prediction of viral evolution and delivered to mice using mRNA–lipid nanoparticles.

Irregular neuronal activity is thought to underlie motor variability. Here the authors use a combination of modelling, neuronal recordings in singing birds and analysis of babbling vocalizations, including of human infants, to show that topographically organized inputs to a widely recurrent motor network self-organize to generate variable motor output.

This study highlights the role Polar regions as a limiting factor in global sustainability due to teleconnection effects, and then propose a SDG target, key indicators, and emphasize Indigenous inclusion and global action.

Disorder has emerged as a promising tool to manipulate properties of superconducting circuits. Here the authors demonstrate the use of disordered spinodal superconductor for fluxonium qubit fabrication and reveal an interesting correlation between the material disorder and the 1/f-type flux noise.

An enhanced superconducting pairing temperature (T_g) has only been observed in single-layer FeSe interfaced with TiO_x system. Here, the authors construct a new interface composed of single-layer FeSe interfaced with LaFeO₃ showing a highest T_g of 80 K among all-known interfacial superconductors.

Increased susceptibility to gastrointestinal infections and colitis can be driven by a failure to maintain intestinal homeostasis. Here, using a forward genetic screen, Song et al. identify and characterise the role of TVP23B in Paneth cell and goblet cell function, and its impact on colitis.

A study finds that RUVBL2 is a conserved component of eukaryotic circadian clocks and suggests that slow ATPase activity, which was initially discovered in cyanobacteria, is a shared feature of eukaryotic clocks.

Multi-ancestry fine-mapping of breast cancer susceptibility regions identifies candidate causal variants and prioritizes likely effector genes supported by functional genomic evidence.

Superconductivity mediated by phonons is usually conventional due to isotropic electron-phonon coupling. Here, Wang et al. report highly anisotropic phonons only along [001] direction in Sr_0.1Bi₂Se₃, indicating a singular electron-phonon coupling which favors a p-wave nematic superconductivity scenario.

Previous work using chemical inhibitors has reported the need for the mitochondrial pyruvate carrier for the classical activation of macrophages. In this study, Ran, Zhang et al. use a genetic approach to show that LPS-stimulated macrophage activation does not require the import of pyruvate into mitochondria.

Renal cell carcinoma consists of several subtypes, and recurrence is highly dependent on subtype. Here, the authors develop a multi-classifier using imaging, lncRNA and clinical data to predict recurrence in papillary renal cell carcinoma.

FlyWire is an online community and a platform for proofreading electron microscopy-based connectome data of the Drosophila brain.

Analysing gut microbial time series from wild baboons, the authors show that microbiome dynamics are rarely synchronized across hosts in shared environments but are highly individualized even within the same social groups.

Moderate disorder can induce topologically nontrivial phases. Liu et al. report the experimental observations of the competition and interplay between Thouless pumping and disorder on a 41-qubit superconducting quantum processor.

Here, the authors integrate genomic and transcriptomic data obtained from African-ancestry female participants and identify six genes associated with breast cancer risk which provides biological insights into this common cancer in an underrepresented population.

While the conversion of CO₂ to high-value products provides a promising means to remove and utilize atmospheric carbon, few materials can do so without wasteful, sacrificial reagents. Here, authors prepare single-atom Co on Bi₃O₄Br nanosheets as CO₂ reduction catalysts using water and light.

Topological magnonic materials display exotic properties which may enable high-efficiency and low-cost spintronic devices. Here the authors demonstrate a three-dimensional antiferromagnet Cu₃TeO₆ that hosts symmetry-protected Dirac and triply degenerate magnons.

A point mutation in the phosphoribosylpyrophosphate synthetase gene is found to rewire C1 metabolism and thereby enhance colonization capabilities and growth-promoting effects in plants. The effect of this mutation is prevalent across Methylobacterium strains.

This study proposes an integrated sensing and communication (ISAC) scheme leveraging space-timecoding metasurfaces (STCMs), which enables concurrent wireless communication and sensing on a shared platform.

Efficient air electrodes drive reversible proton ceramic electrochemical cells, accelerating renewable energy conversion and storage. Here, the authors propose a highly active hybrid air electrode that effectively controls phase content, enhancing electrochemical activity and stability through synergistic effects.

One of the most efficient method to access chiral poly-substituted pyrrolidines is the catalytic asymmetric 1,3-dipolar cycloaddition, but using this reaction with weakly activated alkenes remains elusive. Here, the authors disclose a copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides and 1,3-enynes.

The tRNA synthases AARS1 and AARS2 are identified as evolutionarily conserved sensors of intracellular l-lactate to mediate the global lysine lactylome.

Quantum devices offer the potential to simulate quantum phenomena, which are otherwise computationally intractable. Here, Shi, Sun, Wang and coauthors use a superconducting quantum simulator to study spin-transport at infinite temperature.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by tick-borne SFTS virus. Here, Wang et al. characterize transcriptomic and epigenetic changes in infected patients and correlate them with clinical parameters to improve the understanding of disease progression.

The fabrication of n- and p-type semiconducting channels based on the same layered material would simplify the implementation of 2D electronics. Here, the authors report a spatially selective doping method for the synthesis of wafer-scale p- and n-type 2H-MoTe₂ thin films, and their application for the realization of complementary 2D transistor and inverter arrays.

The authors observe an exceptional point and the corresponding phase transition in a superconducting non-Hermitian circuit. They find non-reciprocal microwave transmission can be achieved within the broken symmetry phase in the few-photon regime.

A deep mutational scanning approach identifies mutations that allow subvariants of the prevalent JN.1 SARS-CoV-2 strain to evade Omicron-induced neutralizing antibodies, indicating a need for careful monitoring of this lineage in vaccine development.

Flexible thermogalvanic device provides a sustainable platform for body heat harvesting, but its performance is limited by low energy conversion efficiency and poor mechanical strength. The authors report a flexible thermogalvanic armor with a Carnot-relative efficiency of 8.53% and strong mechanical toughness.

The targeted epigenetic repression of a β₂-microglobulin super-enhancer downregulates the expression of human leucocyte antigens on mesenchymal stromal cells, making the cells suitable for allogeneic cell therapy.

There are various indigenous cattle breeds in East Asia which have a complex history. Here, the authors analyse the genomes of 49 modern breeds and eight ancient samples and identify three distinct ancestries and multiple adaptive introgressions from other bovine species.

Mechanical allodynia can be socially transferred. Here, authors show that a small population of mice exhibit resilience to socially transferred allodynia, an active process mediated by ventral tegmental area glutamatergic circuits.

Endosomal recycling relies on SNX17 to transport membrane proteins via Retriever. Here, authors reveal the mechanisms of SNX17 autoinhibition and its interaction with Retriever, uncovering a broader family of factors with similar binding strategies.

The perpendicular Néel order in a collinear antiferromagnetic insulator—chromium oxide—can be switched by 180° via the spin–orbit torque with a low current density of 5.8 × 10⁶ A cm⁻² and read out via the anomalous Hall effect.

During the activation and migration of T cells volume changes occur in response to osmolality cues which is not fully understood. Here the authors characterize the function of volume regulated ion channels in T cells and show that these channels regulate TCR sensitivity, thymic selection and TCR repertoire.

Long noncoding RNAs (lncRNAs) can be used for the development of prognostic signatures to predict tumour metastasis. Here the authors identify an immune-associated nine-lncRNA signature for predicting metastasis in a multicentre cohort of locoregionally advanced nasopharyngeal cancer patients.

A filtering reconfigurable intelligent surface is presented with sharp frequency-selecting and 2-bit phase-shifting properties, offering to advance the development of wireless communications with anti-interference and signal-manipulation abilities.