Small-molecule compounds that target the BET ___domain in proteins such as BRD4 have recently been identified as potential anticancer agents; here, the efficacy of the BRD4-targeting compound JQ1 is demonstrated in castration-resistant prostate cancer driven by deregulated androgen receptor action.
- Irfan A. Asangani
- Vijaya L. Dommeti
- Arul M. Chinnaiyan