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Stereoselective synthetic routes use P3HB (a polyester produced by bacteria) as a chiral feedstock for related polymers that have properties more amenable to processing and use.

Fabricating thin lithium electrodes is challenging due to lithium’s fragility and viscosity. Here, authors convert surface Li₂CO₃ on Ta-doped Li₇La₃Zr₂O₁₂ to a lithiophilic layer via trifluoromethanesulfonic acid treatment, enabling precise control over lithium metal negative electrode thickness.

Heavy metals and plastics are two major environmental pollutants. Here, the authors engineer microbial platforms capable of endogenously biosynthesizing phosphomelanin for simultaneously heavy metals adsorption and plastics degradation.

Here, the authors identify a copy number variation containing three enhancers (PIHEC) that drives bilateral constricted ear by co-ordinately regulating HMX1 expression, revealing how aberrant Hmx1 expression in neural crest-derived fibroblasts disrupts outer ear development.

Rearrangement reactions serve as crucial steps in syntheses of biologically active products and also provide intellectual and conceptual curiosities within the broad field of organic chemistry. Here, the authors report an electrophilic selenylation/semipinacol rearrangement of allenols, catalysed by a chiral Lewis base.

Sliding ferroelectricity with finite conductance can yield ferroelectric hysteresis with concomitant Coulomb screening in monolayer graphene containing van der Waals heterostructures of various compositions.

Liver endothelial cells respond differentially to various insults, influencing the liver’s niche and disease outcomes. Here the authors show that in response to bile acid chenodeoxycholic acid during cholestasis, endothelial Myc activation triggers P-selectin expression, promoting neutrophil infiltration and liver damage.

Egg-laying performance is an important phenotype for breeding chicken. Here, the authors explore the regulatory networks driving phenotypic differences in egg-laying, and identify laying-related variants and endocrine factors.

SNARE proteins are the minimal machinery required for the vesicle fusion in eukaryotes. Here the authors use single-molecule fluorescence spectroscopy to elucidate the chain of events during the disassembly of SNARE complex by NSF, showing two parallel sequential pathways for SNARE disassembly.

In moiré superlattices of rhombohedral trilayer graphene aligned on boron nitride, heating may counterintuitively promote spin–valley polarization, transforming metallic ground states into insulators at high temperatures, which deepens the understanding of isospin flavor polarization in correlated electronic systems.

Using synergistic bimetallic catalysis, a general ring expansion strategy has been developed for cross-dimerization between three-membered aza heterocycles and three- and four-membered-ring ketones. This method provides a straightforward and broadly applicable route for the assembly of 3-benzazepinones, dihydropyridinones and uracils, which are versatile units in numerous drugs and biologically active compounds.

Lipid utilization from the yolk sac plays a crucial role in embryonic development. Here, Chen et al. generate hsd17b12a mutant zebrafish and discover that a docosahexaenoic acid (DHA)-phosphatidic acid (PA)-phosphatidylglycerol (PG) (DHA-PA-PG) axis facilitates the uptake of yolk lipids and promotes the expansion of digestive organs.

The authors improve the energy storage performance and high temperature stability of lead-free tetragonal tungsten bronze dielectric ceramics through high entropy strategy and band gap engineering.

Here, by performing multi-omics microbiome analyses in a cohort of children with new-onset T1D, the authors characterize altered microbial functional and metabolic traits involved in T1D, which they validate in animal experiments, together providing potential avenues for microbiome-based interventions.

Here, the authors target intratumoral T_reg cells to enhance antitumor immunity without affecting systemic T_reg cell function and identify JMJD1C as a critical epigenetic regulator of tumor T_reg cell fitness.

From metagenomic sequencing of coastal soils along a salinity gradient, this study shows contrasting eco-evolutionary strategies for relieving carbon limitation under salt stress in bacteria and archaea. The findings suggest that bacteria conserve energy through genome streamlining when facing salt stress, while archaea invest in carbon-acquisition pathways to broaden their resource usage.

Genomic and phenomic screens of 827 wheat landraces from the A. E. Watkins collection provide insight into the wheat population genetic background, unlocking many agronomic traits and revealing haplotypes that could potentially be used to improve modern wheat cultivars.

TAGAP gene variants are linked to human autoimmunity. Here the authors identify TAGAP as a Dectin-1 and EphB2-binding protein mediating antifungal innate immune signaling and cytokine production, and demonstrate TAGAP in non-T cells promotes Th17 response in mouse models of infection and autoimmunity.

Tumour-associated neutrophil populations enriched in the myeloid-cell-enriched tumour immune microenvironment subtype are associated with unfavourable prognosis in humans and mice with liver cancer.

While Ru-based electrocatalysts are among the most active for acidic water oxidation, they suffer from severe deactivation. Now, Yuen Wu, Wei-Xue Li and co-workers report a core–shell Ru₁–Pt₃Cu catalyst with surface-dispersed Ru atoms for a highly active and stable oxygen evolution reaction in acid electrolyte.

Biodegradable glasses are a sustainable alternative to traditional glass. Here high-entropy cyclic peptide glasses are engineered, with enhanced crystallization resistance, mechanical properties and enzyme tolerance.

Sufficient supply of sulfonate group donor is critical to biomanufacturing of the sulfate containing compounds. Here, the authors engineer two sulfonate group donor regeneration systems, including 3'-phosphoadenosine-5'-phosphosulfate and the newly discovered 5'-phosphosulfate, to boost biosynthesis of sulfated compounds.

Two-photon absorption (TPA) affords unparalleled spatiotemporal resolution for bioimaging, but the photo-oxidation tends to weaken the photoluminescence in vivo, limiting the usefulness of TPA probes. Here, the authors report self-assembling near-infrared cyanine dye-based nanoprobes of enhanced TPA fluorescence imaging capacity based on a photo-oxidation enhanced emission mechanism.

Here the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.

Interfacial ferroelectricity may emerge in moiré superlattices. Here, the authors find that the polarized charge is much larger than the capacity of the moiré miniband and the associated anomalous screening exists outside the band.

Introgression is an important source of genetic variation. Analysing genomes of two sympatric widespread Asian oak species, the authors find introgression across the genome and signatures of adaptive introgression in regions with suppressed recombination rate.

“The combination of stimuli responsive nanomaterials and 3D printing leads interesting applications in the fields of soft robots and actuators. Here, the authors present a 3D printing approach for the fabrication of liquid metal nanoparticles-polymer composites acting as light controlled soft robots which can lift weights, grasp and release items”.

A Hi-C study reveals the dynamic chromatin architecture of breast muscle and gene expression affected by breed-specific 3D genome architecture that may influence muscle growth and intramuscular fat deposition between fast-growing and slow-growing chickens.