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Showing 1–14 of 14 results
Advanced filters: Author: Ruofan Yu Clear advanced filters

  • The authors reveal that the chromatin architectural proteins CTCF and RAD21 organize DNA around nuclear speckles to enhance gene induction. This structural organization, when disrupted as in Cornelia de Lange syndrome, impairs key gene functions, providing insight into potential disease mechanisms.

    • Ruofan Yu
    • Shelby Roseman
    • Shelley L. Berger
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1069-1080

  • This study reports that nuclear speckle constituents have two expression states in cancer correlating with patient survival and HIF-2α functional programs. HIF-2α mediates nuclear speckle association of key genes activated in renal cancer.

    • Katherine A. Alexander
    • Ruofan Yu
    • Shelley L. Berger
    Research
    Nature Cell Biology
    Volume: 27, P: 322-335

  • While the shortwave infrared (SWIR) region has potential for bioimaging applications, stable and biocompatible SWIR absorbers/emitters are challenging to access. Here, the authors report the approach of crystal-aided aggregate synthesis for the development of J-aggregates for in vivo bioimaging.

    • Cheng Yao
    • Ruwei Wei
    • Youjun Yang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Mitochondrial DNA or retrotransposon cDNA released into the cytoplasm is degraded to prevent sterile inflammation. In this study, the authors demonstrate that nucleolytic degradation of these DNA species in a yeast model organism prevents their transfer to the nucleus and genome instability.

    • Yang Yu
    • Xin Wang
    • Grzegorz Ira
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The authors demonstrate enhancement by nearly two-orders of magnitude of the optical Stark effect in WSe2 embedded into a Fabry Perot cavity, and use this mechanism to obtain an effective magnetic field of over 200 T and implement a XOR switch.

    • Lingxiao Zhou
    • Bin Liu
    • Hui Deng
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-7

  • Skull-base chordoma (SBC) is a rare, aggressive bone cancer, but its molecular features remain to be characterised. Here, the authors perform proteogenomic analysis of 187 SBC tumours and identify chromosomal instability as a potential prognostic factor and potential therapeutic targets.

    • Qilin Zhang
    • Ziyan Xu
    • Chen Ding
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-32

  • Histone acetylations are important epigenetic marks for transcriptional activation and respond to metabolic changes. Here the authors develop a lifespan screen and show that inactivation of the histone deacetylase complex activates longevity and protects against stress via trehalose metabolism.

    • Ruofan Yu
    • Xiaohua Cao
    • Weiwei Dang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Copper-based catalysts are traditionally very effective for the hydrogenation of CO2 to methanol, although control over the active site has remained elusive. Here, the authors design a Cu1/ZrO2 single-atom catalyst featuring a Cu1–O3 site responsible for a remarkable performance at 180 °C.

    • Huibo Zhao
    • Ruofan Yu
    • Li Tan
    Research
    Nature Catalysis
    Volume: 5, P: 818-831

  • There has been substantial interest in using magnons for information processing. At low magnetic fields, many magnets can form complex ___domain structures. Here, Li et al study how magnons propagate in a ferrimagnet with domains, finding that the passage of magnons is remarkably insensitive to this complex ___domain landscape.

    • Ruofan Li
    • Lauren J. Riddiford
    • Tianxiang Nan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-7

  • The authors show that aged mammalian stem cells produce aberrant transcripts due to profound yet characteristic changes to chromatin during aging, a phenomenon only previously known to occur in simple invertebrate models, limiting their lifespan.

    • Brenna S. McCauley
    • Luyang Sun
    • Weiwei Dang
    Research
    Nature Aging
    Volume: 1, P: 684-697

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29