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Nature Neuroscience (3)
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Showing 1–4 of 4 results

Advanced filters: Author: Samira Parhizkar Clear advanced filters

Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy

Parhizkar et al. show that lemborexant, an orexin receptor antagonist, protects against neurodegeneration in male tau transgenic mice by preventing tau protein build-up and inflammation, highlighting its potential for preventing neurodegeneration.

Samira Parhizkar
Xin Bao
David M. Holtzman
Research27 May 2025
Nature Neuroscience

P: 1-13
Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Samira Parhizkar
Thomas Arzberger
Christian Haass
Amendments and Corrections14 Aug 2024
Nature Neuroscience

Volume: 27, P: 1858-1859
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Loss of Trem2 function increases early amyloidogenesis by preventing microglial activation and clustering around amyloid seeds. As a consequence of reduced microglial ApoE production in the absence of Trem2 function, amyloid plaques contain less ApoE.

Samira Parhizkar
Thomas Arzberger
Christian Haass
Research07 Jan 2019
Nature Neuroscience

Volume: 22, P: 191-204
Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer’s disease models

Marie-Christine Pardon
Maria Yanez Lopez
Henryk M Faas
ResearchOpen Access27 Jan 2016
Scientific Reports

Volume: 6, P: 1-12