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Showing 1–11 of 11 results

Advanced filters: Author: Samuele Ferrari Clear advanced filters

Mechanisms of hematopoietic clonal dominance in VEXAS syndrome

Analyses of single-cell transcriptomic data from patients with VEXAS syndrome combined with xenotransplantation experiments in a mouse model of the disease provide insights on the mechanisms of clonal dominance of mutated cells leading to bone marrow failure

Raffaella Molteni
Martina Fiumara
Samuele Ferrari
ResearchOpen Access07 Apr 2025
Nature Medicine

Volume: 31, P: 1911-1924
Author Correction: Genotoxic effects of base and prime editing in human hematopoietic stem cells

Martina Fiumara
Samuele Ferrari
Luigi Naldini
Amendments and CorrectionsOpen Access25 Jan 2024
Nature Biotechnology

Volume: 42, P: 986
Metformin reduces the competitive advantage of Dnmt3a^R878H HSPCs

Dnmt3a mutations in mouse haematopoietic stem and progenitor cells equivalent to R882 mutations in human cause increased mitochondrial respiration, suggesting that this is a mechanism of clonal haematopoiesis and a potential therapeutic target.

Mohsen Hosseini
Veronique Voisin
Steven M. Chan
Research16 Apr 2025
Nature

Volume: 642, P: 421-430
Genotoxic effects of base and prime editing in human hematopoietic stem cells

Base and prime editors induce double-strand breaks, deletions and translocations in hematopoietic cells.

Martina Fiumara
Samuele Ferrari
Luigi Naldini
ResearchOpen Access07 Sept 2023
Nature Biotechnology

Volume: 42, P: 877-891
Context-dependent selectivity to natural images in the retina

Ganglion cells classically respond to either light increase (ON) or decrease (OFF). Here, the authors show that during natural scene stimulation, a single ganglion cell can switch between ON and OFF depending on the visual context.

Matías A. Goldin
Baptiste Lefebvre
Olivier Marre
ResearchOpen Access22 Sept 2022
Nature Communications

Volume: 13, P: 1-12
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking

Transient p53 inhibition and induced cell-cycle progression increase clonal engraftment and homology-directed repair in hematopoietic stem cells.

Samuele Ferrari
Aurelien Jacob
Luigi Naldini
Research29 Jun 2020
Nature Biotechnology

Volume: 38, P: 1298-1308
Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases

In budding yeast, the 53BP1 ortholog Rad9 limits the resection nucleolytic processing of DNA double strand breaks. Here the authors reveal that Rad9 promotes long tract gene conversions, BIR and CO, during the HR repair of a DSB via modulation of Sgs1 and Mph1 helicases.

Matteo Ferrari
Chetan C. Rawal
Achille Pellicioli
ResearchOpen Access23 Jun 2020
Nature Communications

Volume: 11, P: 1-11
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Pseudovirus assays and surface plasmon resonance show that the Omicron receptor-binding ___domain binds to human ACE2 with increased affinity relative to the ancestral virus, and that most neutralizing antibodies are considerably less potent against Omicron.

Elisabetta Cameroni
John E. Bowen
Davide Corti
Research23 Dec 2021
Nature

Volume: 602, P: 664-670
BAR-Seq clonal tracking of gene-edited cells

In this protocol, barcodes are introduced into cells via homology-directed targeted integration, and clones are tracked in xenotransplanted hosts by high-throughput sequencing. The results can be analyzed using a freely available online program.

Samuele Ferrari
Stefano Beretta
Pietro Genovese
Protocols24 May 2021
Nature Protocols

Volume: 16, P: 2991-3025
Prospective analysis of sex differences and factors associated with suicidal thoughts and behaviours in young people from the MILESTONE Italian sample

Gabriele Torino
Silvia Leone
Stefano Vicari
ResearchOpen Access24 Oct 2024
Scientific Reports

Volume: 14, P: 1-12
Publisher Correction: Prospective analysis of sex differences and factors associated with suicidal thoughts and behaviours in young people from the MILESTONE Italian sample

Gabriele Torino
Silvia Leone
Stefano Vicari
Amendments and CorrectionsOpen Access27 Nov 2024
Scientific Reports

Volume: 14, P: 1-2