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Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Cao et al. report an A-site co-doping strategy by substituting Cs+ cation by alkali metals for perovskite quantum wires embedded in nanoporous alumina template, stabilising the crystal structure and enabling high-colour purity LEDs spanning from blue to green spectral region.

Understanding how copper nanoparticles evolve under electrochemical conditions is crucial for the development of selective CO₂ reduction electrocatalysts. Here the authors prepare well-defined nanocrystals and use advanced operando imaging and spectroscopic techniques to reveal the Cu–CO species-driven dynamic evolution of Cu electrodes.

The prevalence of mutations that can predispose to pancreatic adenocarcinoma (PDAC) remains unclear, especially in underrepresented populations. Here, the authors create a germline mutation map of 1,123 Chinese PDAC patients and compare them to cohorts from other populations, finding CFTR as a potential driver.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Drug resistance is inevitable and pervasive. Here, the authors identify the V517F mutation as a significant contributor to USP7-mediated inhibitor resistance. This discovery offers valuable insights for the development of next-generation USP7 inhibitors.

LAPTM4A deficiency impedes M2 polarization of tumor-associated macrophages in glioblastoma, enhancing immune activation and improving the efficacy of anti-PD1 therapy, offering potential therapeutic targets for glioma treatment.

Insulinomas develop from pancreatic β-cells and secrete insulin, but the underlying genetic defects are largely unknown. In this study, Cao et al. identify recurrent T372R mutations in the transcription factor YY1, and validate this hotspot mutation in 30% of insulinomas.

Piwi-interacting RNAs (piRNAs) are vital for genome integrity and fertility. Here the authors reveal that spatial clustering of piRNA genes in Caenorhabditis elegans promotes transcription through phase separation and deSUMOylation, uncovering a SUMOylation-regulated mechanism for piRNA production in heterochromatic genomes.

The authors demonstrate an AI-enhanced imaging method combining lipid-specific dyes and super-resolution microscopy enables simultaneous tracking of up to 15 organelles in living cells, revealing dynamic interactions across diverse biological systems.

A zeolite-confined Cu single-atom cluster was developed for the electrochemical CO reduction application, which can achieve stable CO-to-acetate conversion at an industrial current density of 1 A cm⁻² at 2.7 V with a high acetate Faraday efficiency for over 1,000 h at atmospheric pressure.

Platinum-based therapies are a key component of colorectal cancer therapy, but patients often become resistant. Here, the authors identify a non-canonical function of glutamate-cysteine ligase modifier (GCLM) wherein its nuclear translocation increases NF-κB activity promoting resistance to platinum-based chemotherapy in colorectal cancer.

Here, Zhang et al. succeed in creating a heavily distorted oxygen deficient film of lanthanum cobaltite. The new phase of LaCoO_2.5 has several unique properties, most notably, a Curie temperature of 284 K, significantly larger than the films from which it was derived.

Circularly polarised luminescence (CPL) is essential for asymmetric synthetic photochemistry. Here, the authors integrate white quantum dots with chiral nematic liquid crystal or liquid crystal polymer to achieve single-emitted tuneable full-colour or white CPL for enantioselective polymerization.

Visible light-induced glycosylation reactions are achieved by either photoactivating a photosensitizer or using a stoichiometric activator, while glycosylation via a photoactive glycosyl donor was so far not reported. In this study, the authors develop a photosensitizer free visible-light-mediated glycosylation approach using photoactive 2-glycosyloxy tropone as the donor, obtaining a wide range of O-glycosides or oligosaccharides.

Hydrogen peroxide (H₂O₂) is a green oxidant with diverse applications. Aided by a nickel phosphorus trisulfide nanosheet electrocatalyst, this work shows a sustainable synthetic route to produce H₂O₂ from seawater with high yield and impressive stability.

Exploring the dual-emission mechanism in open-shell nanoclusters with doublet or quartet emissions remains challenging. Here, the authors reveal the origin of dual-quartet phosphorescent emission in the open-shell M1Ag13 (M = Pt, Pd) nanoclusters.

Here the authors experimentally realize the electrical tuning of branched flow of light in nematic liquid crystals. The statistical properties and the polarization effect of the branched flow of light in the film are systematically studied adding fundamental insights on branched flow of light.

This study identifies the phenomenon of outsourced carbon mitigation in Chinese cities. It found that about 78% of these cities outsource their carbon mitigation efforts in varying degrees, which affects the way carbon mitigation policies should work.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

The critical floating phase can bridge crystalline orders and the disordered phase. Here, the authors experimentally observe the quantum floating phase in neutral atom qubit arrays, revealing ___domain walls and incommensurate quasi long-range order, and analyse its emergence via Fourier spectroscopy.

KtrAB complex is essential in K⁺ uptake for bacteria. Here authors illustrate the synergism of ATP and Na⁺ in activating K+ uptake of KtrAB from Bacillus subtilis and its gating mechanism, which may also shed light on other Na⁺-activated K⁺ channels.

In China, about 10 percent of industrial sectors are the least efficient water users across 343 prefectures, and water savings opportunities exist in agriculture, the clothing and chemical industry, according to an analysis that uses water withdrawal data.

Despite recent progress in individual nanocluster synthesis, understanding the competing or coexisting effects between particles in solution remains challenging. Here, the authors present the synthesis of a bi-nanocluster system comprising two atomically precise nanoclusters, and map out the interdependent relationship between them.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Upconversion nanoparticles offer the potential for deep tissue biological imaging. Here, Chen et al. develop super resolution optical imaging in the near-infrared for imaging with sub-50 nm resolution through almost 100 microns of tissue.

The global supply chain and demand for export goods can lead to relocated emissions. Goods produced in China for foreign markets have lead to an increase of domestic non-methane volatile organic compounds emissions by 3.5 million tons in 2013 resulting in potentially an estimated 16,889 premature deaths annually.

Until recently, the three-body recombination reaction was widely regarded as the only reaction pathway to the production of molecular oxygen in Earth's prebiotic primitive atmosphere. Observation of a CO₂ photodissociation pathway altered this view, but now, using anion velocity imaging, a further source of molecular oxygen is revealed, formed via the dissociative electron attachment to CO₂.

Anlotinib hydrochloride is a multi-target tyrosine kinase receptor inhibitor, previously combined with anti-PD1 as therapeutic strategy for several cancer types. Here the authors report the results of a phase II trial of nivolumab (anti-PD1) plus anlotinib hydrochloride in patients with advanced gastric adenocarcinoma and esophageal squamous cell carcinoma.

The LKB1 signaling is differentially regulated and has distinct functions at different subcellular compartments. Tu et al reports that TBC1D23 specifically regulates Golgi-LKB1 signaling and link this pathway to neurodevelopment disorders.