Activating NRAS mutations are frequently oncogenic drivers of melanoma; however, attempts to therapeutically target mutant NRAS have remained largely unsuccessful. Here, the authors identify an axis of mutant NRAS regulation wherein casein kinase 1δ (CK1δ) promotes USP46-mediated stabilisation of oncogenic NRAS.
- Yalei Wen
- Hui Wang
- Tongzheng Liu
