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Scientific Reports (17)
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Showing 1–50 of 53 results

Advanced filters: Author: Shuguang Lin Clear advanced filters

PRPS2 enhances RNA m⁶A methylation by stimulating SAM synthesis through enzyme-dependent and independent mechanisms

Cancer cells exploit altered metabolic pathways to dynamically regulate epigenetic methylations. Here, the authors show the canonical metabolic and nonmetabolic functions of PRPS2 in enhancing ATP utilization and SAM biosynthesis, promoting RNA m⁶A methylation for lung tumorigenesis and metastasis.

Lin Zhang
Xian Zhao
Liang Zhang
ResearchOpen Access28 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Finite element analysis of pedicle screw fixation biomechanics and adjacent segment degeneration in varied bone conditions

Linling Zhang
Zhongxiang Yu
Huihao Wang
ResearchOpen Access30 May 2025
Scientific Reports

Volume: 15, P: 1-12
Palladium-catalysed synthesis of triaryl(heteroaryl)methanes

Molecules with 4 aryl groups attached to a central carbon atom have proven challenging to synthesize despite their attractiveness for a variety of applications. Here the authors report a Pd-catalysed arylation of di- and triarylmethanes, giving a high-yielding route to an array of tetraarylmethanes.

Shuguang Zhang
Byeong-Seon Kim
Patrick J. Walsh
ResearchOpen Access14 Mar 2017
Nature Communications

Volume: 8, P: 1-8
T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots

Liu and colleagues examine how severe acute respiratory syndrome coronavirus 2 variants evade CD8⁺ T cell epitope recognition.

Jinmin Tian
Bingli Shang
Jun Liu
Research28 Jan 2025
Nature Immunology

Volume: 26, P: 265-278
Sex differences in the association of physical activity patterns with all-cause and cardiovascular mortality: a prospective cohort study from NHANES 2007–2018

Ailing He
Yunkai Wang
Lin Zhang
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis

Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S] cluster, which is essential and participates in the catalytic cycle.

Jiashen Zhou
Lin Zhang
Liang Zhang
ResearchOpen Access26 Nov 2021
Nature Communications

Volume: 12, P: 1-13
T1198C Polymorphism of the Angiotensinogen Gene and Antihypertensive Response to Angiotensin-Converting Enzyme Inhibitors

Huimin Yu
Shuguang Lin
Wenjun Ma
Research01 Dec 2005
Hypertension Research

Volume: 28, P: 981-986
A multistage drug delivery approach for colorectal primary tumors and lymph node metastases

Lymph node (LN) metastases after primary treatment may end up with disease recurrence and poor survival rate. Here this group designs a phospholipase A₂ (sPLA₂)-responsive nanosystem delivering doxorubicin for in vivo inhibition of both primary colorectal tumor progression and LN metastasis.

Yihang Yuan
Quanjun Lin
Chao Fang
ResearchOpen Access07 Feb 2025
Nature Communications

Volume: 16, P: 1-19
Development and clinical validation of a novel platelet count-based nomogram for predicting microvascular invasion in HCC

Wenjie Zheng
Haoqi Chen
Shuguang Zhu
ResearchOpen Access18 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
Hepatitis B core antigen upregulates B7-H1 on dendritic cells by activating the AKT/ERK/P38 pathway: a possible mechanism of hepatitis B virus persistence

Man Li
Zhen-Hua Zhou
Yue-Qiu Gao
Research12 Sept 2016
Laboratory Investigation

Volume: 96, P: 1156-1164
Yuanhuacine suppresses head and neck cancer growth by promoting ASCT2 degradation and inhibiting glutamine uptake

Xin-yi Chen
Xin Chen
Xin Luan
Research15 May 2025
Acta Pharmacologica Sinica

P: 1-14
Fine pore engineering in a series of isoreticular metal-organic frameworks for efficient C₂H₂/CO₂ separation

The separation of acetylene and carbon dioxide by porous materials requires delicate control over the pore size. Herein, the authors fine-tune the pore size at sub-nanometer scale in a series of isoreticular metal-organic frameworks to control the acetylene/carbon dioxide separation performance; subtle structural differences lead to remarkable performance enhancement.

Jun Wang
Yan Zhang
Banglin Chen
ResearchOpen Access11 Jan 2022
Nature Communications

Volume: 13, P: 1-8
A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity

Mazdutide is a once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. Here, the authors show mazdutide was well tolerated over 24 weeks and demonstrated significant and clinically meaningful body weight loss, compared with placebo, in Chinese overweight adults or adults with obesity.

Linong Ji
Hongwei Jiang
Lei Qian
ResearchOpen Access14 Dec 2023
Nature Communications

Volume: 14, P: 1-10
Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation

Mi-2β is an enzyme of the chromodomain helicase DNA family with roles in chromatin assembly, genomic stability and gene repression. Here the authors report that Mi-2β promotes immune evasion by activating EZH2 methylation and that loss of Mi-2β or its inhibition promote anti-tumor immune responses in preclinical melanoma models.

Cang Li
Zhengyu Wang
Rutao Cui
ResearchOpen Access09 Mar 2024
Nature Communications

Volume: 15, P: 1-18
A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging

The second messenger cAMP modulates a wide range of important biological processes. Here, the authors developed a fluorescent indicator termed G-Flamp1, which can accurately report levels of cAMP in living cells.

Liang Wang
Chunling Wu
Jun Chu
ResearchOpen Access12 Sept 2022
Nature Communications

Volume: 13, P: 1-16
Bufalin suppresses hepatocarcinogenesis by targeting β-catenin/TCF signaling via cell cycle-related kinase

Zhuo Yu
Hai Feng
Yueqiu Gao
ResearchOpen Access01 Mar 2018
Scientific Reports

Volume: 8, P: 1-11
Chromosome-scale genome assembly of three-spotted seahorse (Hippocampus trimaculatus) with a unique karyotype

Ning Li
Xinhui Zhang
Qiong Shi
ResearchOpen Access11 Jan 2025
Scientific Data

Volume: 12, P: 1-8
Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma

Glioblastoma (GBM) cells are metabolically dependent on exogenous cholesterol uptake and targeting cholesterol metabolism has been proposed as a therapeutic option for GBM. Here the authors show that cholesterol promotes phagocytic dysfunction in tumor associated macrophages and they develop an Apo-A1 armed oncolytic adenovirus restoring anti-tumor immunity in GBM preclinical models.

Wang Shiqun
Yan Wei
Wei Jiwu
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-21
Gene expression during the differentiation of bone marrow stem cells into cardiomyocytes

Xiaohong Li
Xiyong Yu
Shuguang Lin
Research04 Aug 2008
Cell Research

Volume: 18, P: S52
Publisher Correction: Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis

Yu Wang
Rajesh Narasimamurthy
Nick Barker
Amendments and Corrections08 May 2024
Nature Cancer

Volume: 5, P: 809
Association between cholesterol intake and pancreatic cancer risk: Evidence from a meta-analysis

Hongqiang Chen
Shiyong Qin
Shuguang Zhang
ResearchOpen Access04 Feb 2015
Scientific Reports

Volume: 5, P: 1-6
Small-molecule activation of the TRAIL receptor DR5 in human cancer cells

Bioymifi, a small-molecule death receptor 5 (DR5) agonist, induces selective cancer cell apoptosis as a single agent or in synergy with small-molecule Smac mimetics.

Gelin Wang
Xiaoming Wang
Xiaodong Wang
Research23 Dec 2012
Nature Chemical Biology

Volume: 9, P: 84-89
Advanced fault ___location method for three-terminal distribution lines using frequency characteristics and µPMU data

Shuguang Li
Houhe Chen
Xiaozhe Song
ResearchOpen Access13 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Computational drug development for membrane protein targets

Drug discovery is being transformed by advances in computational protein structure prediction and protein design.

Haijian Li
Xiaolin Sun
Horst Vogel
Reviews15 Feb 2024
Nature Biotechnology

Volume: 42, P: 229-242
Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Detailed knowledge of the characteristics of COVID-19 patients helps with public health planning. Here, the authors use routinely-collected data from seven databases in three countries to describe the characteristics of >30,000 patients admitted with COVID-19 and compare them with those admitted for influenza in previous years.

Edward Burn
Seng Chan You
Patrick Ryan
ResearchOpen Access06 Oct 2020
Nature Communications

Volume: 11, P: 1-11
The locust genome provides insight into swarm formation and long-distance flight

Locusts are destructive agricultural pests and serve as a model organism for studies of insects. Here, the authors report a draft genome sequence of the migratory locust, Locusta migratoria, and provide insight into genes associated with key survival traits such as phase-change, long-distance migration and feeding.

Xianhui Wang
Xiaodong Fang
Le Kang
ResearchOpen Access14 Jan 2014
Nature Communications

Volume: 5, P: 1-9
Bushen Yijing Fang Reduces Fall Risk in Late Postmenopausal Women with Osteopenia: A Randomized Double-blind and Placebo-controlled Trial

Yuxin Zheng
Xuezong Wang
Aiping Lu
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.

Fang Qiu
Ruqi Tang
Xiong Ma
ResearchOpen Access20 Apr 2017
Nature Communications

Volume: 8, P: 1-8
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

The application of a potent lactate dehydrogenase (LDHA) inhibitor GNE-140 on pancreatic cancer cells revealed that resistance to GNE-140 is attributable to an AMPK–mTOR–S6K-mediated switch in utilization from glycolysis to oxidative phosphorylation.

Aaron Boudreau
Hans E Purkey
Thomas O'Brien
Research01 Aug 2016
Nature Chemical Biology

Volume: 12, P: 779-786
Application of artificial intelligence in quantifying lung deposition dose of black carbon in people with exposure to ambient combustion particles

Menghui Jiang
Chelin Jamie Hu
Shuguang Leng
Research17 Oct 2023
Journal of Exposure Science & Environmental Epidemiology

Volume: 34, P: 529-537
Identification of Novel MAGE-G1-Interacting Partners in Retinoic Acid-Induced P19 Neuronal Differentiation Using SILAC-Based Proteomics

Yong Liu
Yujian Chen
Shaojun Liu
ResearchOpen Access04 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
Charactering the metabolism of cryptotanshinone by human P450 enzymes and uridine diphosphate glucuronosyltransferases in vitro

Jin Zeng
Yu-juan Fan
Fu-rong Qiu
Research08 Feb 2018
Acta Pharmacologica Sinica

Volume: 39, P: 1393-1404
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis

Barker and colleagues discuss the interplay between circadian rhythm, the tumor microenvironment and stem cells and how these are linked to metastasis as well as how these interactions could be clinically relevant.

Yu Wang
Rajesh Narasimamurthy
Nick Barker
Reviews23 Apr 2024
Nature Cancer

Volume: 5, P: 546-556
Multi-omics analysis of the development and fracture resistance for maize internode

Xiaqing Wang
Ruyang Zhang
Jiuran Zhao
ResearchOpen Access03 Jun 2019
Scientific Reports

Volume: 9, P: 1-11
Author Correction: p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy

Xiaoxuan Xu
Xuejing Zhu
Lin Sun
Amendments and CorrectionsOpen Access08 Apr 2020
Scientific Reports

Volume: 10, P: 1-2
Compatibility Study of Danggui Buxue Tang on Chemical Ingredients, Angiogenesis and Endothelial Function

Ping-Lan Lin
Zhi-Cheng Li
Xin Zhou
ResearchOpen Access22 Mar 2017
Scientific Reports

Volume: 7, P: 1-15
ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells

Zhiling Zhou
Jiaxin Zhan
Meng Zheng
ResearchOpen Access10 Feb 2022
Cell Death & Disease

Volume: 13, P: 1-10
Isolation and characterization of an atypical LEA gene (IpLEA) from Ipomoea pes-caprae conferring salt/drought and oxidative stress tolerance

Jiexuan Zheng
Huaxiang Su
Mei Zhang
ResearchOpen Access16 Oct 2019
Scientific Reports

Volume: 9, P: 1-21
p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy

Xiaoxuan Xu
Xuejing Zhu
Lin Sun
ResearchOpen Access05 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis

Haijiao Jin
Yuanting Yang
Qisheng Lin
ResearchOpen Access17 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-11
HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome

Jialin Li
Qisheng Lin
Zhaohui Ni
ResearchOpen Access17 Mar 2023
Cell Death & Disease

Volume: 14, P: 1-12
Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NF-κB-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice

Yong-Hua Li
Hai-Long Fu
Hong-Bin Yuan
ResearchOpen Access27 Jan 2016
Scientific Reports

Volume: 6, P: 1-12
Severe summer heatwave and drought strongly reduced carbon uptake in Southern China

Wenping Yuan
Wenwen Cai
Guomo Zhou
ResearchOpen Access07 Jan 2016
Scientific Reports

Volume: 6, P: 1-12
Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin

Shao-yu Wu
Guang-fa Wang
Jia-jie Zhang
Research05 Jan 2009
Acta Pharmacologica Sinica

Volume: 30, P: 202-208
Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells

Guang-fa Wang
Shao-yu Wu
Jia-jie Zhang
Research06 Apr 2009
Acta Pharmacologica Sinica

Volume: 30, P: 589-596
Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways

Xue-mei Li
Jing-hua Peng
Yi-yang Hu
Research02 May 2016
Acta Pharmacologica Sinica

Volume: 37, P: 783-793
Improved chromosome-level genome assembly of Indian sandalwood (Santalum album)

Xinhua Zhang
MingZhi Li
Guohua Ma
ResearchOpen Access21 Dec 2023
Scientific Data

Volume: 10, P: 1-10
Deep learning downscaled high-resolution daily near surface meteorological datasets over East Asia

Hai Lin
Jianping Tang
Guangtao Dong
ResearchOpen Access12 Dec 2023
Scientific Data

Volume: 10, P: 1-13
Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex

Q Ji
L Zhang
Q Li
ResearchOpen Access15 Jul 2014
British Journal of Cancer

Volume: 111, P: 736-748
Genomewide Analysis of Rat Periaqueductal Gray-Dorsal Horn Reveals Time-, Region- and Frequency-Specific mRNA Expression Changes in Response to Electroacupuncture Stimulation

Ke Wang
Xiao-Hui Xiang
Cai-Lian Cui
ResearchOpen Access27 Oct 2014
Scientific Reports

Volume: 4, P: 1-8

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