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Scientific Reports (25)
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Showing 1–50 of 70 results

Advanced filters: Author: Shuhua Yang Clear advanced filters

Natural variation in CTB4a enhances rice adaptation to cold habitats

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

Zhanying Zhang
Jinjie Li
Zichao Li
ResearchOpen Access23 Mar 2017
Nature Communications

Volume: 8, P: 1-13
Organometallic-type reactivity of stable organoboronates for selective (hetero)arene C−H/C-halogen borylation and beyond

The polarity separation within the carbon-metal bonds of traditional organometallic reagents that endows them with exceptional reactivities also imposes limitations, such as air and moisture sensitivity, and flammability. Here, the authors demonstrate that stable and easily accessible benzylic (or allylic) boronate with mild alkali-metal alkoxide as the activator can act as organometallic reagents.

Xueting Liu
Daojing Li
Shuhua Li
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Natural polymorphism of ZmICE1 contributes to amino acid metabolism that impacts cold tolerance in maize

mGWAS reveals ZmICE1 as a key hub for integrating amino acid metabolic pathways and cold tolerance in maize. Natural variation in ZmICE1 promoter regulates the binding affinity of ZmMYB39, which confers the diverse cold tolerance in maize.

Haifang Jiang
Yiting Shi
Shuhua Yang
Research14 Oct 2022
Nature Plants

Volume: 8, P: 1176-1190
A receptor–kinase cascade confers cold-induced root growth inhibition in Arabidopsis

A receptor–kinase module involving KOIN and CRPK1 integrates membrane trafficking and kinase signalling to mediate cold-induced root growth inhibition in Arabidopsis via the 14-3-3–CBF3–SHR pathway.

Xiuyue Zhang
Minze Li
Shuhua Yang
Research27 Jun 2025
Nature Plants

P: 1-14
Natural variation in a type-A response regulator confers maize chilling tolerance

The genetic basis of low-temperature tolerance in maize is unclear. Here, the authors show that the type-A Response Regulator 1 (ZmRR1) and mitogen-activated protein kinase (MPK8) are positive and negative regulators of maize chilling tolerance, and ZmRR1 is phosphorylated by ZmMPK8 during cold treatment.

Rong Zeng
Zhuoyang Li
Shuhua Yang
ResearchOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1-13
Plant community restoration time is a key factor affecting plant nutrient and species richness

Yonghong Luo
Jiming Cheng
Xingfu Yan
ResearchOpen Access06 May 2025
Scientific Reports

Volume: 15, P: 1-9
A pangenome reference of 36 Chinese populations

A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.

Yang Gao
Xiaofei Yang
Shuhua Xu
ResearchOpen Access14 Jun 2023
Nature

Volume: 619, P: 112-121
Large-scale lexical and genetic alignment supports a hybrid model of Han Chinese demic and cultural diffusions

By digitizing a large lexical dataset of Chinese dialects and comparing it to genetic profiles, Yang et al. reveal a hybrid model of language diffusion, consisting of both population migrations and social learning across different regions of China.

Chengkun Yang
Xiaoxi Zhang
Menghan Zhang
Research13 May 2024
Nature Human Behaviour

Volume: 8, P: 1163-1176
Author Correction: Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc

Xinghuo Wu
Zhiwei Liao
Cao Yang
Amendments and CorrectionsOpen Access11 Jun 2025
Experimental & Molecular Medicine

Volume: 57, P: 1343-1346
Direct synthesis of sila-benzoazoles through hydrosilylation and rearrangement cascade reaction of benzoazoles and silanes

Sila-substituted compounds have potential application in medicinal chemistry, but their preparation from the corresponding carbon analogues remains challenging. Here, the authors report the synthesis of sila-benzoazoles via hydrosilylation and rearrangement of benzoazoles; the reaction is enabled by a Lewis acid.

Tianwei Liu
Mo Yang
Yuetao Zhang
ResearchOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-9
Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility

Genetic studies of Chinese individuals have been performed, but mostly with short read sequencing, limiting the types of variants that can be identified. Here, the authors perform long read sequencing of 945 han Chinese individuals, finding structural variants under natural selection and those associated with human traits and evolutionary history.

Jiao Gong
Huiru Sun
Shaohua Fan
ResearchOpen Access10 Feb 2025
Nature Communications

Volume: 16, P: 1-21
Regulation of alternative splicing by CBF-mediated protein condensation in plant response to cold stress

CBF transcription factors facilitate the formation of SKIP nuclear condensates to increase the splicing efficiency of cold-responsive transcripts, bridging transcriptional and post-transcriptional regulation during cold acclimation.

Diyi Fu
Yue Song
Yiting Shi
Research05 Mar 2025
Nature Plants

Volume: 11, P: 505-517
Nickel-catalyzed, silyl-directed, ortho-borylation of arenes via an unusual Ni(II)/Ni(IV) catalytic cycle

Nickel-catalyzed C–H bond functionalization reactions provide an impressive alternative to those with noble metal catalysts but the regioselective C(sp²)−H borylation reaction of arenes accomplished by nickel catalyst remains challenging. Here the authors disclose a silyl-directed ortho C(sp²)−H borylation of substituted arenes with a Ni(cod)₂/PMe₃/KHMDS catalyst system.

Xiaoshi Su
Guoao Li
Shuhua Li
ResearchOpen Access30 Aug 2024
Nature Communications

Volume: 15, P: 1-12
Pathogenicity and Bro gene typing of pediatric lower respiratory tract infections with Moraxella catarrhalis in Southwest Shandong, China

Yuhan Xiang
Jian Shi
Shuhua Lu
ResearchOpen Access29 Apr 2025
Scientific Reports

Volume: 15, P: 1-10
Impact of rare non-coding variants on human diseases through alternative polyadenylation outliers

Rare variants (RVs) significantly impact human diseases. Here, the authors conducted a comprehensive cross-tissue analysis of alternative polyadenylation outliers (aOutliers) and discovered a unique class of aOutliers-associated RVs with a large effect on disease.

Xudong Zou
Zhaozhao Zhao
Lei Li
ResearchOpen Access16 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Optimal vein access selection in adrenal vein sampling via upper extremity approach: a retrospective analysis of 325 cases

Furong Zhang
Ni Zhu
Jun Qian
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-5
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

G protein-coupled receptors (GPCRs) are a critical target in modern drug development across a wide range of indications. Here the authors provide a comprehensive characterization of a typical GPCR, the angiotensin II (AngII) type 1 receptor (AT1R), and provide insight into its activation mechanism that suggest avenues for the design of allosteric GPCR modulators.

Shaoyong Lu
Xinheng He
Jian Zhang
ResearchOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Copine proteins are required for brassinosteroid signaling in maize and Arabidopsis

Brassinosteroids play vital role in plant growth and development. Here, the authors demonstrate that the plasma membrane-associated copine proteins are new components required for the receptor complex functioning in BR signaling in maize and Arabidopsis.

Teng Jing
Yuying Wu
Mingyue Gou
ResearchOpen Access08 Mar 2024
Nature Communications

Volume: 15, P: 1-14
MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes

Yukun Zhang
Jie Jia
Hongtao Tian
ResearchOpen Access28 Feb 2014
Experimental & Molecular Medicine

Volume: 46, P: e79
MiR-17-5p modulates osteoblastic differentiation and cell proliferation by targeting SMAD7 in non-traumatic osteonecrosis

Jie Jia
Xiaobo Feng
Zhipeng Dai
ResearchOpen Access25 Jul 2014
Experimental & Molecular Medicine

Volume: 46, P: e107
Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0

Existing methods to identify the presence of DNA from other hominin species can be limited in the ability to accurately estimate introgression waves, or can only be applied to specific populations. Here, the authors have developed a generalizable method to identify introgression in multi-wave situations.

Kai Yuan
Xumin Ni
Shuhua Xu
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-15
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression

Hypoxia occurs at high altitude and in cancer. Here, the authors show that a gene involved in hypoxia, YTHDF1, underwent rapid evolution in Tibetans and their domestic animals, and find that the gene is amplified in some cancers and contributes to drug resistance in hypoxic conditions.

Yulin Shi
Songqing Fan
Yongbin Chen
ResearchOpen Access25 Oct 2019
Nature Communications

Volume: 10, P: 1-14
Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling

IL-17 mediated inflammation in the lung is mediated by different effector molecules. Here the authors show that the epigenetic regulator epithelial sirtuin 6 (Sirt6) is associated with lung inflammation in asthma patients and that Sirt6 contributes to promotion of inflammation in mouse asthma models.

Jingyun Quan
Xiaoxia Wen
Tianwen Lai
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-14
Data imbalance in cardiac health diagnostics using CECG-GAN

Yang Yang
Tianyu Lan
Xing Chen
ResearchOpen Access26 Jun 2024
Scientific Reports

Volume: 14, P: 1-16
Physical model experiment on the influence of water depth on the underwater pipeline surface impacted by landslide surge

Hong Ji
Weikang Liu
Shuhua Zhao
ResearchOpen Access29 Sept 2021
Scientific Reports

Volume: 11, P: 1-11
CRAT downregulation promotes ovarian cancer progression by facilitating mitochondrial metabolism through decreasing the acetylation of PGC-1α

Zhen Zhang
Shuhua Zhao
Xiaohong Zhang
ResearchOpen Access19 Jan 2025
Cell Death Discovery

Volume: 11, P: 1-14
Excellent magnetocaloric properties in RE₂Cu₂Cd (RE = Dy and Tm) compounds and its composite materials

Yikun Zhang
Yang Yang
Gerhard Wilde
ResearchOpen Access26 Sept 2016
Scientific Reports

Volume: 6, P: 1-9
Use of antimicrobial peptides as a feed additive for juvenile goats

Qi Liu
Shuhua Yao
Shumin Yu
ResearchOpen Access25 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
Chromosome-level genome assembly of the planthopper Nilaparvata muiri

Cilin Wang
Ju Luo
Shuhua Liu
ResearchOpen Access19 Sept 2024
Scientific Data

Volume: 11, P: 1-8
Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases

Signaling by the plant hormone abscisic acid (ABA) is regulated by the ABI1 protein phosphatase. Here Kong et al.propose that ABA signaling is fine-tuned by ubiquitination of ABI1 which promotes ABI degradation in response to ABA.

Lingyao Kong
Jinkui Cheng
Zhizhong Gong
ResearchOpen Access20 Oct 2015
Nature Communications

Volume: 6, P: 1-13
Trends in rare disease drug development

Rui Chen
Sen Liu
Shuyang Zhang
Comments & Opinion06 Nov 2023
Nature Reviews Drug Discovery

Volume: 23, P: 168-169
Drought meets SWEET

Plants adapt to drought stress by reshaping their root architecture, a process in which abscisic acid signalling plays a key role. A recent study defines the mechanism by which abscisic acid signalling mediates sucrose transport from shoots to roots, thus modulating root growth under drought stress.

Zhizhong Gong
Shuhua Yang
News & Views23 Dec 2021
Nature Plants

Volume: 8, P: 25-26
A missense point mutation in COL10A1 identified with whole-genome deep sequencing in a 7-generation Pakistan dwarf family

Chao Zhang
Jiaojiao Liu
Shuhua Xu
Research10 Nov 2017
Heredity

Volume: 120, P: 83-89
A bibliometric analysis of international publication trends in premature ejaculation research (2008–2018)

Jialiang Hui
Li Wang
Anyang Wei
Research02 Jan 2020
International Journal of Impotence Research

Volume: 33, P: 86-95
Thickness Effects for Thermoelectric Property of Antimony Telluride Nanoplatelets via Solvothermal Method

Xinxin Yan
Wenwen Zheng
Ziyu Wang
ResearchOpen Access29 Nov 2016
Scientific Reports

Volume: 6, P: 1-8
Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study

Yang Liu
Liangliang Zhang
Xiangyin Kong
ResearchOpen Access05 Jul 2013
Scientific Reports

Volume: 3, P: 1-5
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome

Zi-Jiang Chen and colleagues report a genome-wide association analysis for polycystic ovary syndrome (PCOS) in Han Chinese. They identify eight new susceptibility loci for PCOS in this population.

Yongyong Shi
Han Zhao
Zi-Jiang Chen
Research12 Aug 2012
Nature Genetics

Volume: 44, P: 1020-1025
Pretreatment neutrophil-to-lymphocyte ratio is associated with immunotherapy efficacy in patients with advanced cancer: a systematic review and meta-analysis

Jialin Su
Yuning Li
Lemeng Zhang
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-17
Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations

Asifullah Khan
Lei Tian
Shuhua Xu
ResearchOpen Access05 Jan 2016
Scientific Reports

Volume: 6, P: 1-7
The development of a high-density genetic map significantly improves the quality of reference genome assemblies for rose

Shubin Li
Guoqian Yang
Kaixue Tang
ResearchOpen Access12 Apr 2019
Scientific Reports

Volume: 9, P: 1-13
The complete and fully-phased diploid genome of a male Han Chinese

Chentao Yang
Yang Zhou
Guojie Zhang
ResearchOpen Access14 Jul 2023
Cell Research

Volume: 33, P: 745-761
Bacillus velezensis A2 fermentation exerts a protective effect on renal injury induced by Zearalenone in mice

Nan Wang
Peng Li
Shuhua Yang
ResearchOpen Access11 Sept 2018
Scientific Reports

Volume: 8, P: 1-14
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc

Xinghuo Wu
Zhiwei Liao
Cao Yang
ResearchOpen Access25 Sept 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-16
Inference of multiple-wave admixtures by length distribution of ancestral tracks

Xumin Ni
Kai Yuan
Shuhua Xu
Research23 Jan 2018
Heredity

Volume: 121, P: 52-63
Impact of seasonal changes in urban green spaces with diverse vegetation structures on college students' physical and mental health

Yifan Duan
Hua Bai
Qiuchen Zhu
ResearchOpen Access15 Jul 2024
Scientific Reports

Volume: 14, P: 1-15
MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3

Cheng Hao
Shuhua Yang
Yong Feng
ResearchOpen Access02 Mar 2016
Scientific Reports

Volume: 6, P: 1-13
Real-time predictive model of extrauterine growth retardation in preterm infants with gestational age less than 32 weeks

Liang Gao
Wei Shen
Xiaohong Liu
ResearchOpen Access05 Jun 2024
Scientific Reports

Volume: 14, P: 1-13
MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway

Shuhua Zhao
Lu Cheng
Hong Yang
ResearchOpen Access05 Jan 2021
Cell Death & Disease

Volume: 12, P: 1-14
Cancer-derived exosomal miR-375 targets DIP2C and promotes osteoblastic metastasis and prostate cancer progression by regulating the Wnt signaling pathway

Ying Liu
Changmou Yang
Jialiang Hui
Research25 Nov 2022
Cancer Gene Therapy

Volume: 30, P: 437-449

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