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A cost-effective all-in-one halide cathode material with high energy density and exceptional cycling stability can be used to achieve energy-dense, durable cathodes for the next generation of all-solid-state batteries.

Peptide-based materials offer advantages for constructing supramolecular chiral systems due to their bioactivity and intrinsic chirality but precise control over the expression, transfer, and amplification of chirality is a significant challenge. Here, the authors demonstrate that achiral anions regulate hydrogen bonding interactions in dipeptide assembly, leading to the formation of chiral microrolls composed of 2D nanosheets.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Through multimodal analyses of human cardiac tissues across different ages, Fan, Zheng, Zhan, Xu, Liu and colleagues reveal that RNA-binding protein ARID5A drives inflammaging by stabilizing the MAVS mRNA and activating the NF-κB–TBK1 pathway, and show that inactivating myocardial ARID5A attenuates cardiac senescence and functional decline.

Cyclic dimeric adenosine monophosphate is found to be a second messenger in eukaryotic cells that is generated by adenylate cyclase 7 and connects Toll-like receptor 9 stimulation to nucleotide-binding ___domain, leucine-rich repeat protein 3 inflammasome activation.

This paper introduces an oxide-dispersion-strengthening strategy that enables sub-100 μm. high-precision additive manufacturing of copper, thereby addressing the limitations of current processes for microscale technologies.

Song et al. report stochastic edge detection enabled by integrating memristor-based stochastic number encoders with logic gates to perform bitwise logic operations with statistical probabilities. A hardware Roberts cross operator achieves 95% less computational cost while withstands up to 50% bit-flip errors.

Cell type deconvolution is crucial for studying disease and development. Here, the authors present SCCAF-D, a workflow that reduces batch effects and achieves high correlation across tissues, offering key insights into cell proportion changes in non-alcoholic fatty liver disease.

Here, the authors suggest a role of the lysine acetyltransferase KAT7 in inhibiting procentriole formation and colorectal tumorigenesis via competitive antagonism of its crotonylation against acetylation.

Adenoids and tonsils in children can become hypertrophic because of multiple infections. Here the authors use single cell transcriptomics to assess the immune cell composition of these hypertrophic organs and find B, T and NK cells and exhausted memory CD4 T cells indicating immune changes in these organs associated with respiratory infection.

Li et al. report the sublattice decoupling in Rb₆Re₆S₈I₈ upon compression, in which [Rb₆I₂]⁴⁺ framework can be selectively amorphized while the [Re₆S₈I₆]^4- clusters keep in ordered state, leading to emission-to-photocurrent switching at 15 GPa, which can retain when back to ambient condition.

Effective dehydrogenation of amino acids and short peptides using cobalt and photocatalysis is used to make a range of unnatural products of value in chemistry and biology.

Electrocardiogram is crucial for cardiovascular disease prevention, diagnosis, and prognosis. Here, the authors present a motion-unrestricted dynamic electrocardiogram system utilizing skin-conformal, imperceptible electronics for long-term, comfortable, and accurate 12-lead monitoring.

Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.

Efficient charge separation plays a crucial role in enhancing artificial photocatalysis. Here, the authors report an alkali etching method to construct an electron transfer layer on BiVO₄:Mo photocatalysts, leading to a charge separation efficiency exceeding 90% at 420 nm.

Duan, Hu, Han, Lei, Wang et al. report that ADSL-mediated production of fumarate suppresses STING activation and impairs T cell and NK cell infiltration, thereby facilitating immune evasion in breast cancer.

Cui et al. report analogue photoelectronic reservoir computing with IGZO synaptic transistors as the reservoir and TaOX-based memristor array as the output layer. A receptive field inspired encoding scheme is implemented to simplify the feature extraction for dynamic vision processing.

Cell-free gene expression (CFE) systems are often constrained by numerous biochemical components required to maintain biocatalytic efficiency. Here, the authors propose a droplet-AI combined approach to perform high-throughput and efficient combinatorial screening of CFE. This work led to simplified CFE systems with improved yield and cost-effectiveness.

This paper reports the discovery of two fossils of Rhamnaceae preserved in amber that provide evidence of fire adaptation in Cretaceous angiosperms.

Here the authors measure viral load in samples from skin lesions, saliva, oropharynx, and rectum of 77 patients with acute monkeypox virus infection as well as from environmental fomite swabs and show a high seropositivity rate for antibodies against A29L and H3L.

CRISPR-Cas12e systems exhibit robust genome editing capabilities, yet their phylogenetic diversity remains underexplored. Here, authors elucidate the biochemical diversity and structural variations of newly identified Cas12e proteins, offering critical insights into structure-activity relationships.

Fan, Shang, Song, Chen et al. identify the Integrator–PP2A complex (INTAC) as a key regulator of cancer cell sensitivity to BET inhibitors through directly interacting with the RACK7–KDM5 complex to orchestrate epigenetic silencing in a catalytic-independent manner.

Adult human hearts exhibit restricted regenerative ability, where cardiomyocyte loss leads to dysfunction, while neonatal hearts can regenerate, though the molecular mechanisms remain poorly understood. Here, the authors show that N-cadherin plays a crucial role in driving cardiomyocyte self-renewal by stabilizing β-catenin, representing a unique opportunity to promote cardiac regeneration and restore contractile function in the injured adult heart

The rapid coal power phaseout is expected to lead to uncertain socio-economic consequences. This study in China reveals that the impacts on macro-level performance and subjective well-being are driven in opposite directions during the phaseout.

Comprehensive analyses of Cas9 proteins shed light on the evolution of the CRISPR–Cas9 system, and identify a pro-CRISPR accessory protein in bacteria that boosts CRISPR-mediated immunity by enhancing the DNA binding and cleavage activity of Cas9.

The authors synthesize metal-organic cage crosslinked nanocomposites by incorporating self-assembled metal-organic cages with amino reaction sites into the polyetherimide matrix. The in-situ crosslinking achieves a homogeneous distribution of inorganic components, constructing robust organic-inorganic interfaces.

The balance between apoptosis and autophagy is critical for normal development, proper tissue function, and disease pathogenesis. Here, the authors show previously unannotated BIRC6 domains, including a ubiquitin-like ___domain, and how it utilizes its ubiquitylation function to regulate both apoptosis and autophagy.

The engineering of an enzyme’s structural conformation and dynamic properties to promote its catalytic activity and stability outside cellular environments is challenging. Here, the authors combine the rationally designed liquid-solid hybrid microreactor with a tailor-made polyethylene glycol functional ionic liquid microenvironment to obtain a high level of control over the configuration of confined enzymes for practical continuous-flow biocatalysis.

α-Pyridones and α-pyrones are ubiquitous structural motifs found in natural products and components of biologically active small molecules. Here, the authors report an oxidant-free Rh-catalyzed electrochemical divergent vinylic C–H annulation of acrylamides with alkynes to α-pyridones and cyclic imidates.

On rare occasions, some multiple myeloma patients develop pure red cell aplasia (PRCA) following combination therapy for multiple myeloma. Here the authors characterise bone marrow cells from PRCA patients by single cell sequencing showing hyperactive CD8⁺ T cells, impaired erythropoiesis, increase of MHC-I proteins and antigen presentation associated genes in erythroid cells.

Monolithic photonics devices based on SiC are fabricated by a wafer bonding and thinning technique. The strong enhancement of single-photon emission from a colour centre and optical frequency conversion with an efficiency of 360% W⁻¹ are demonstrated.

Current diamond quantum optics experiments are restricted to single devices and few quantum emitters due to fabrication constraints. Here, the authors utilize inverse design to overcome constraints of diamond nanofabrication methods and fabricate compact and robust diamond devices with unique specifications.

Macrophage metabolism controls differentiation and subsequent adaptive immune responses. Here the authors show that mitochondrial membrane protein Fam73b regulates TLR-mediated mitochondrial switching of fusion to fission to induce IL-12 production via accumulation of Parkin and stabilization of IRF1 in macrophages, resulting in control of anti-tumor immunity in mice.

Both cartilaginous and bony fishes have adaptive immune cells, but the evolutionary features of these diverse cell populations remain understudied. Here the authors report single-cell RNA sequencing atlas of both species to define these features and to find reduced evolutionary diversification of immune cells in cartilaginous fishes.

A high-throughput yeast display platform is used to analyse the profiles of mutations in the SARS-CoV-2 receptor-binding ___domain (RBD) that enable escape from antibodies, and suggests that most anti-RBD antibodies can be escaped by the Omicron variant.

Due to the deformable nature of soft robots, developing robust sensors that can sustain stability and performance is a challenge. Here, the authors report a computational strain sensor design based on a programmed crack array for predictable, tunable, and stable sensing performance.

Genomic, transcriptomic and DNA methylation data from tissue samples from 208 Chinese patients with prostate cancer define the landscape of alterations in this population, and comparison with data from Western cohorts suggests that the disease may stratify into different molecular subtypes.