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Showing 1–13 of 13 results
Advanced filters: Author: Siddharth Sridhar Clear advanced filters

  • Rat hepatitis E virus (HEV) can infect humans, but the extent of spillover isn’t well studied. Here the authors develop a serological test that distinguishes exposure to rat HEV from other HEV infection and show substantial spillover in a biodiversity hotspot in China. The method can support surveillance of rat HEV.

    • Zihao Chen
    • Lifeng Wang
    • Zizheng Zheng
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Hong Kong experienced a severe wave of SARS-CoV-2 in early 2022. Here, the authors use genomic and serosurveillance data and show that this wave was dominated by the Omicron BA.2 sublineage, and that low protective immunity, particularly in older age groups, contributed to its severity.

    • Lin-Lei Chen
    • Syed Muhammad Umer Abdullah
    • Kelvin Kai-Wang To
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The rich ethnolinguistic and sociocultural differences that exist in India offers a unique opportunity to study human diversity. With the whole genomes of 10,000 healthy and unrelated Indians from 83 populations, the GenomeIndia project captures the genetic diversity of one of the highly underrepresented populations in the global genomics landscape.

    • Chandrika Bhattacharyya
    • Krithika Subramanian
    • Bratati Kahali
    Comments & Opinion
    Nature Genetics
    Volume: 57, P: 767-773

  • Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

    • Dinesh Aggarwal
    • Andrew J. Page
    • Ewan M. Harrison
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

    • Dinesh Aggarwal
    • Ben Warne
    • Ian G. Goodfellow
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282

  • Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

    • Dami A. Collier
    • Anna De Marco
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 593, P: 136-141

  • In this Review, Chan et al. explore major drug discovery approaches, preclinical antiviral evaluation models, virus-targeting and host-targeting therapeutic strategies, and key treatments currently used in clinical settings for COVID-19.

    • Jasper Fuk-Woo Chan
    • Shuofeng Yuan
    • Kwok-Yung Yuen
    Reviews
    Nature Reviews Microbiology
    Volume: 22, P: 391-407