Metabolic dysfunction is an important characteristic of vascular smooth muscle cells (VSMCs) phenotypic transition in aortic dissection. Here, the authors show lncRNA H19 could encode a peptide, GMRSP. GMRSP regulates the glycolysis by counteracting hnRNP A2B1-mediated pyruvate kinase M pre-mRNA alternative splicing and control the phenotypic transition of VSMCs.
- Jizhong Wang
- Jitao Liu
- Jianfang Luo
