Nature Search

The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies

Leming Shi
Wendell Jones
Weida Tong
ResearchOpen Access03 Jul 2007
Nature Precedings

P: 1
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies

Leming Shi
Wendell Jones
Weida Tong
ResearchOpen Access02 Jul 2007
Nature Precedings

P: 1
A randomized study to evaluate safety and immunogenicity of the BNT162b2 COVID-19 vaccine in healthy Japanese adults

Here the authors provide the interim analysis of an ongoing phase 1/2 study of the BNT162b2 vaccine in healthy Japanese adults. They report mainly mild to moderate local reactions and no serious adverse events as well as good antibody induction one month after the second dose.

Miwa Haranaka
James Baber
Stephen Lockhart
ResearchOpen Access14 Dec 2021
Nature Communications

Volume: 12, P: 1-7
Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two–colour fluorescence analysis

Joseph G. Hacia
Lawrence C. Brody
Francis S. Collins
Research01 Dec 1996
Nature Genetics

Volume: 14, P: 441-447
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health

LXRα is highly expressed in hepatocytes, where it regulates cholesterol abundance and stimulates lipogenesis. The authors provide evidence in humans and mice that impaired LXRα signalling is hepatotoxic, despite its potent lipogenic actions.

Sam M. Lockhart
Milan Muso
Stephen O’Rahilly
ResearchOpen Access25 Sept 2024
Nature Metabolism

Volume: 6, P: 1922-1938
Evolutionary sequence comparisons using high-density oligonucleotide arrays

Joseph G. Hacia
Wojciech Makalowski
Francis S. Collins
Research01 Feb 1998
Nature Genetics

Volume: 18, P: 155-158
Genetic effects on gene expression across human tissues

Samples of different body regions from hundreds of human donors are used to study how genetic variation influences gene expression levels in 44 disease-relevant tissues.

François Aguet
Andrew A. Brown
Jingchun Zhu
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 204-213
Cystic Fibrosis: Enzymatic Detection of a Ciliostatic Factor

Baiba K Gillard
Stephen A Feig
Thomas E Nelson
Research01 Nov 1976
Pediatric Research

Volume: 10, P: 907-910
De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

The non-coding RNA RNU4-2, which is highly expressed in the developing human brain, is identified as a syndromic neurodevelopmental disorder gene, and, using RNA sequencing, 5′ splice-site use is shown to be systematically disrupted in individuals with RNU4-2 variants.

Yuyang Chen
Ruebena Dawes
Nicola Whiffin
ResearchOpen Access11 Jul 2024
Nature

Volume: 632, P: 832-840
Virus genomes reveal factors that spread and sustained the Ebola epidemic

Frequent dispersal and short-lived local transmission clusters fuelled the 2013–2016 Ebola virus epidemic in Guinea, Liberia and Sierra Leone.

Gytis Dudas
Luiz Max Carvalho
Andrew Rambaut
Research12 Apr 2017
Nature

Volume: 544, P: 309-315
Publisher Correction: Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

Mark J. Mulligan
Kirsten E. Lyke
Kathrin U. Jansen
Amendments and Corrections19 Jan 2021
Nature

Volume: 590, P: E26
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Addressing challenges with real-world synthetic control arms to demonstrate the comparative effectiveness of Pralsetinib in non-small cell lung cancer

Real-world data (RWD) based control arms provide an option to compare the effectiveness of single-arm trials. By performing multiple quantitative bias analyses to alleviate concerns about trial-RWD comparability, here the authors show that the RET inhibitor pralsetinib provides survival benefit in patients with RET fusion-positive non-small cell lung cancer from the ARROW single-arm trial, (NCT03037385) when compared to pembrolizumab monotherapy and pembrolizumab with chemotherapy RWD cohorts.

Sanjay Popat
Stephen V. Liu
Vivek Subbiah
ResearchOpen Access17 Jun 2022
Nature Communications

Volume: 13, P: 1-10
Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

In a dose-escalation study of the COVID-19 RNA vaccine BNT162b1 in 45 healthy adults, RBD-binding IgG concentrations and SARS-CoV-2 neutralizing titres in sera increased with dose level and after a second vaccine dose.

Mark J. Mulligan
Kirsten E. Lyke
Kathrin U. Jansen
Research12 Aug 2020
Nature

Volume: 586, P: 589-593
Differences between Cystic Fibrosis and Normal Saliva α-Amylase as a Function of Age and Sex

Baiba K Gillard
Henry C Markman
Stephen A Feig
Research01 Aug 1978
Pediatric Research

Volume: 12, P: 868-872
A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors

Confining plasma and managing disruptions in tokamak devices is a challenge. Here the authors demonstrate a method predicting and possibly preventing disruptions and macroscopic instabilities in tokamak plasma using data from JET.

Andrea Murari
Riccardo Rossi
Michela Gelfusa
ResearchOpen Access18 Mar 2024
Nature Communications

Volume: 15, P: 1-19
Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

For many neurodevelopmental disorder (NDD) risk genes, the significance for mutational burden is unestablished. Here, the authors sequence 125 candidate NDD genes in over 16,000 NDD cases; case-control mutational burden analysis identifies 48 genes with a significant burden of severe ultra-rare mutations.

Tianyun Wang
Kendra Hoekzema
Evan E. Eichler
ResearchOpen Access01 Oct 2020
Nature Communications

Volume: 11, P: 1-13
Transcriptional regulation and function during the human cell cycle

Raymond J. Cho
Mingxia Huang
David J. Lockhart
Research01 Jan 2001
Nature Genetics

Volume: 27, P: 48-54
Genomic epidemiology reveals multiple introductions of Zika virus into the United States

Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Caribbean is the most likely source.

Nathan D. Grubaugh
Jason T. Ladner
Kristian G. Andersen
Research24 May 2017
Nature

Volume: 546, P: 401-405
Colchicine—an old dog with new tricks

Colchicine is an anti-inflammatory agent that suppresses myeloid cell activation and is commonly used to treat gout. In this issue of Nature Metabolism, Weng et al. demonstrate that colchicine exerts its anti-inflammatory effects in mice via the induction of the hormone GDF-15 in the liver.

Samuel M. Lockhart
Stephen O’Rahilly
News & Views12 Apr 2021
Nature Metabolism

Volume: 3, P: 451-452
High density synthetic oligonucleotide arrays

Robert J. Lipshutz
Stephen P.A. Fodor
David J. Lockhart
Reviews01 Jan 1999
Nature Genetics

Volume: 21, P: 20-24
Efficient generation of energetic ions in multi-ion plasmas by radio-frequency heating

Triggering and sustaining fusion reactions — with the goal of overall energy production — in a tokamak plasma requires efficient heating. Radio-frequency heating of a three-ion plasma is now experimentally shown to be a potentially viable technique.

Ye. O. Kazakov
J. Ongena
I. Zychor
Research19 Jun 2017
Nature Physics

Volume: 13, P: 973-978
The human and non-human primate developmental GTEx projects

The developmental Genotype-Tissue Expression (dGTEx) projects will catalogue and integrate gene expression, regulation and genetics data across 120 human donors from birth to adulthood with developmentally matched non-human primates, including 126 rhesus macaques and 72 common marmosets.

Tim H. H. Coorens
Amy Guillaumet-Adkins
Sige Zou
Reviews15 Jan 2025
Nature

Volume: 637, P: 557-564
The wasting hormone GDF15 frees up fat to fight infection

GDF15 is an anorectic hormone that signals organismal stress to the brain. New data suggest that GDF15 enhances tolerance to acute inflammation by modulating liver lipid metabolism and triglyceride availability in mice.

Samuel M. Lockhart
Stephen O’Rahilly
News & Views07 Oct 2019
Nature Metabolism

Volume: 1, P: 935-936
Engineering evolution to study speciation in yeasts

Daniela Delneri
Isabelle Colson
Stephen G. Oliver
Research06 Mar 2003
Nature

Volume: 422, P: 68-72
Author Correction: Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Tianyun Wang
Kendra Hoekzema
Evan E. Eichler
Amendments and CorrectionsOpen Access21 Oct 2020
Nature Communications

Volume: 11, P: 1
The role of primary healthcare professionals in oral cancer prevention and detection

L M D Macpherson
M F McCann
K W Stephen
Research13 Sept 2003
British Dental Journal

Volume: 195, P: 277-281
Target Identification for CNS Diseases by Transcriptional Profiling

C Anthony Altar
Marquis P Vawter
Stephen D Ginsberg
Reviews15 Oct 2008
Neuropsychopharmacology

Volume: 34, P: 18-54
Diagnostic Spirometry in Primary Care: Proposed standards for general practice compliant with American Thoracic Society and European Respiratory Society recommendations.

Mark L Levy
Philip H Quanjer
Iain R Small
Reviews14 Aug 2009
Primary Care Respiratory Journal

Volume: 18, P: 130-147
Electrophysiological correlates of the flexible allocation of visual working memory resources

Christine Salahub
Holly A. Lockhart
Stephen M. Emrich
ResearchOpen Access19 Dec 2019
Scientific Reports

Volume: 9, P: 1-11
Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Jialiang Yang
Tao Huang
Nicole C. Lockhart
ResearchOpen Access19 Oct 2015
Scientific Reports

Volume: 5, P: 1-16
Correction: Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Jialiang Yang
Tao Huang
Nicole C. Lockhart
Amendments and CorrectionsOpen Access21 Jan 2016
Scientific Reports

Volume: 6, P: 1

Search

The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies

The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies

A randomized study to evaluate safety and immunogenicity of the BNT162b2 COVID-19 vaccine in healthy Japanese adults

Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two–colour fluorescence analysis

Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health

Evolutionary sequence comparisons using high-density oligonucleotide arrays

Genetic effects on gene expression across human tissues

Cystic Fibrosis: Enzymatic Detection of a Ciliostatic Factor

De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

Virus genomes reveal factors that spread and sustained the Ebola epidemic

Publisher Correction: Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Addressing challenges with real-world synthetic control arms to demonstrate the comparative effectiveness of Pralsetinib in non-small cell lung cancer

Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

Differences between Cystic Fibrosis and Normal Saliva α-Amylase as a Function of Age and Sex

A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors

Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Transcriptional regulation and function during the human cell cycle

Genomic epidemiology reveals multiple introductions of Zika virus into the United States

Colchicine—an old dog with new tricks

High density synthetic oligonucleotide arrays

Efficient generation of energetic ions in multi-ion plasmas by radio-frequency heating

The human and non-human primate developmental GTEx projects

The wasting hormone GDF15 frees up fat to fight infection

Engineering evolution to study speciation in yeasts

Author Correction: Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

The role of primary healthcare professionals in oral cancer prevention and detection

Target Identification for CNS Diseases by Transcriptional Profiling

Diagnostic Spirometry in Primary Care: Proposed standards for general practice compliant with American Thoracic Society and European Respiratory Society recommendations.

Electrophysiological correlates of the flexible allocation of visual working memory resources

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Correction: Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

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