Nature Search

Poly(carboxybetaine) lipids enhance mRNA therapeutics efficacy and reduce their immunogenicity

Poly(carboxybetaine) lipids enhance mRNA lipid nanoparticles efficacy and reduce their immunogenicity, being promising alternatives to poly(ethylene) glycol lipids used in traditional mRNA lipid nanoparticle formulations.

Sijin Luozhong
Pingchuan Liu
Shaoyi Jiang
Research29 May 2025
Nature Materials

P: 1-10
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D₃ signalling

Steven A. Kliewer
Kazuhiko Umesono
Ronald M. Evans
Research30 Jan 1992
Nature

Volume: 355, P: 446-449
Autosomal recessive retinitis pigmentosa caused by mutations in the α subunit of rod cGMP phosphodiesterase

Sherleen H. Huang
Steven J. Pittler
Thaddeus P. Dryja
Research01 Dec 1995
Nature Genetics

Volume: 11, P: 468-471
Author Correction: A recellularized human colon model identifies cancer driver genes

Huanhuan Joyce Chen
Zhubo Wei
Michael L Shuler
Amendments and Corrections03 Jun 2019
Nature Biotechnology

Volume: 37, P: 820
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries

Genetic and functional studies implicate allele-specific regulation of OAS1 splicing and nonsense-mediated decay in COVID-19 severity. The OAS1 risk haplotype is also associated with reduced SARS-CoV-2 clearance in a clinical trial with pegIFN-λ1.

A. Rouf Banday
Megan L. Stanifer
Ludmila Prokunina-Olsson
ResearchOpen Access14 Jul 2022
Nature Genetics

Volume: 54, P: 1103-1116
Correction: Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

Miguel Crespo
Eduardo Vilar
Shuibing Chen
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 526
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

Marshall Horwitz, Charles Mullighan, Kenneth Offit and colleagues report the identification of a recurrent germline PAX5 mutation in families with pre–B cell acute lymphoblastic leukemia. They also identify sporadic cases of this leukemia with the same mutation that arose somatically.

Sohela Shah
Kasmintan A Schrader
Kenneth Offit
Research08 Sept 2013
Nature Genetics

Volume: 45, P: 1226-1231
The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer

Steven M Lipkin
Laura S Rozek
Stephen B Gruber
Research06 Jun 2004
Nature Genetics

Volume: 36, P: 694-699
Meiotic arrest and aneuploidy in MLH3-deficient mice

Steven M. Lipkin
Peter B. Moens
Paula E. Cohen
Research01 Jul 2002
Nature Genetics

Volume: 31, P: 385-390
A recellularized human colon model identifies cancer driver genes

An ex vivo model of human colon cancer enables study of the drivers of tumor development and invasion.

Huanhuan Joyce Chen
Zhubo Wei
Michael L Shuler
Research11 Jul 2016
Nature Biotechnology

Volume: 34, P: 845-851
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

The transient reactivation of ETV2 in adult human endothelial cells reprograms these cells to become adaptable vasculogenic endothelia that in three-dimensional matrices self-assemble into vascular networks that can transport blood and physiologically arborize organoids and decellularized tissues.

Brisa Palikuqi
Duc-Huy T. Nguyen
Shahin Rafii
Research09 Sept 2020
Nature

Volume: 585, P: 426-432
miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β

Colorectal cancer (CRC), like many solid tumours, progresses from adenomas to carcinomas in a sequence that leads to metastasis. Here the authors show that miR1269 plays a role in CRC relapse and metastasis by regulating TGF-β activity.

Pengcheng Bu
Lihua Wang
Xiling Shen
Research15 Apr 2015
Nature Communications

Volume: 6, P: 1-12
MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability

Steven M. Lipkin
Victoria Wang
Francis S. Collins
Research01 Jan 2000
Nature Genetics

Volume: 24, P: 27-35
Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells

Tara Srinivasan
Elaine Bich Than
Xiling Shen
ResearchOpen Access16 May 2016
Scientific Reports

Volume: 6, P: 1-8
Electrostatic melting in a single-molecule field-effect transistor with applications in genomic identification

DNA hybridization of two single-strands to form a double-stranded helix is widely used for genomic identification applications. Here, Vernicket al. record duplex formation of 20-mer oligonucleotide using a single-molecule field-effect transistor, where DNA kinetics is affected by electrostatic bias.

Sefi Vernick
Scott M. Trocchia
Kenneth L. Shepard
ResearchOpen Access18 May 2017
Nature Communications

Volume: 8, P: 1-9
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting

New xenograft models of colorectal cancer exhibit metastasis to the liver, use immunocompetent mice and show improved resistance to chemotherapy.

Huanhuan Joyce Chen
Jian Sun
Steven M Lipkin
Research25 May 2015
Nature Biotechnology

Volume: 33, P: 656-660
A 3D structural SARS-CoV-2–human interactome to explore genetic and drug perturbations

This three-dimensional structural SARS-CoV-2–human interactome web server allows hypothesis-driven exploration of the mechanisms of SARS-CoV-2 pathology and host response.

Shayne D. Wierbowski
Siqi Liang
Haiyuan Yu
Research29 Nov 2021
Nature Methods

Volume: 18, P: 1477-1488
Three-dimensional reconstruction of protein networks provides insight into human genetic disease

Large-scale structural genomics and genome-wide association studies generate a wealth of data relevant to human disease. Wang et al. interpret these data in the context of a protein interaction network, showing that systematic analyses of the structural interfaces hit by mutations yield insights into pathogenesis.

Xiujuan Wang
Xiaomu Wei
Haiyuan Yu
Research15 Jan 2012
Nature Biotechnology

Volume: 30, P: 159-164
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

A protocol based on chemical modulation of WNT activity is used to efficiently generate colonic organoids that recapitulate the molecular features of human colon tissue. Colonic organoids generated from induced pluripotent stem cells from patients with familial adenomatous polyposis provide an in vitro platform for disease modeling and preclinical drug testing.

Miguel Crespo
Eduardo Vilar
Shuibing Chen
Research19 Jun 2017
Nature Medicine

Volume: 23, P: 878-884
Case–control analysis identifies shared properties of rare germline variation in cancer predisposing genes

Mykyta Artomov
Vijai Joseph
Mark J. Daly
Research04 Feb 2019
European Journal of Human Genetics

Volume: 27, P: 824-828
Author Correction: Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging

Jiahn Choi
Nikolai Rakhilin
Nozomi Nishimura
Amendments and CorrectionsOpen Access30 Sept 2019
Scientific Reports

Volume: 9, P: 1
Correction: Toward automation of germline variant curation in clinical cancer genetics

Vignesh Ravichandran
Zarina Shameer
Joseph Vijai
Amendments and Corrections21 Mar 2019
Genetics in Medicine

Volume: 21, P: 1668
PMS2 monoallelic mutation carriers: the known unknown

McKinsey L. Goodenberger
Brittany C. Thomas
Noralane M. Lindor
Reviews09 Apr 2015
Genetics in Medicine

Volume: 18, P: 13-19
Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging

Jiahn Choi
Nikolai Rakhilin
Nozomi Nishimura
ResearchOpen Access20 Jul 2018
Scientific Reports

Volume: 8, P: 1-12
Toward automation of germline variant curation in clinical cancer genetics

Vignesh Ravichandran
Zarina Shameer
Joseph Vijai
Research21 Feb 2019
Genetics in Medicine

Volume: 21, P: 2116-2125
Probabilistic atlas for the language network based on precision fMRI data from >800 individuals

Benjamin Lipkin
Greta Tuckute
Evelina Fedorenko
ResearchOpen Access29 Aug 2022
Scientific Data

Volume: 9, P: 1-10
Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma

Maroulio Pertesi
Maxime Vallée
Charles Dumontet
ResearchOpen Access09 Apr 2019
Leukemia

Volume: 33, P: 2324-2330

Search

Poly(carboxybetaine) lipids enhance mRNA therapeutics efficacy and reduce their immunogenicity

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D₃ signalling

Autosomal recessive retinitis pigmentosa caused by mutations in the α subunit of rod cGMP phosphodiesterase

Author Correction: A recellularized human colon model identifies cancer driver genes

Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries

Correction: Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer

Meiotic arrest and aneuploidy in MLH3-deficient mice

A recellularized human colon model identifies cancer driver genes

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β

MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability

Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells

Electrostatic melting in a single-molecule field-effect transistor with applications in genomic identification

Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting

A 3D structural SARS-CoV-2–human interactome to explore genetic and drug perturbations

Three-dimensional reconstruction of protein networks provides insight into human genetic disease

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

Case–control analysis identifies shared properties of rare germline variation in cancer predisposing genes

Author Correction: Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging

Correction: Toward automation of germline variant curation in clinical cancer genetics

PMS2 monoallelic mutation carriers: the known unknown

Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging

Toward automation of germline variant curation in clinical cancer genetics

Probabilistic atlas for the language network based on precision fMRI data from >800 individuals

Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma

Search

Quick links

Search

Filter By:

Search

Quick links