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Real-time joint motion feedback during exercise interventions can enhance hand and wrist rehabilitation. Here, the authors introduce electrogoniometry systems that accurately monitor target joint angles in fingers and wrists in real-time for use in medical and physical activity settings.

Highly pathogenic avian influenza and African swine fever are major animal health concerns and prompt identification of outbreaks is important for disease control. Here, the authors develop a statistical framework to assess the performance of country surveillance systems for detecting outbreaks in animals.

A wireless device for measuring bioimpedance during breastfeeding allows accurate quantification of the volume of expressed milk in 12 new mothers in a neonatal intensive care unit and in home settings.

Fear arises directly or vicariously, with the LC-NA system involved in both. Here, the authors show that the right LC → ACC pathway is key for vicarious fear, while BNST and CeA provide distinct inputs to LC, highlighting its complex role in fear.

Neutrophils are involved in both the initiation and resolution of cardiac inflammation post myocardial infarction (MI). Here, the authors show that intravenously injected nanoparticles can modulate cardiac neutrophils to inhibit inflammation and promote repair for MI therapy.

Here, the authors show that higher levels of the gut bacterial clade TANB77 associate with better response to cancer immunotherapy, and further demonstrate in mice that a conserved pilin from TANB77 plays a role in enhancing immunotherapy efficacy, suggesting a potential therapeutic avenue.

Heat is a form of energy that is transported from a hot to a cold region, but it is not a notion that is associated with the microscopic measurement of electronic properties. It is now shown that local thermoelectric measurements can be used for imaging structural disorder in graphene, with high sensitivity, on the atomic and nanometre scales, uncovering soliton-like ___domain-wall line-patterns separating different graphene regions.

Gangliosides are vital for brain function, but their isomer-specific investigations are limited. Here, the authors use a glyco-lipidomic approach to profile ganglioside isomers and N-glycans in mouse brain regions, revealing regional specificity and commonality.

The application of engineered cardiac tissues is limited due to their immaturity and lack of functionality. Here, the authors develop an integrated culture platform featuring heart extracellular matrix cultured in a microfluidic chip to facilitate cardiac tissue development for versatile biomedical applications.

Hund’s coupling, or the intra-atomic exchange, can drive novel quantum phases in multi-orbital systems, but this requires precise control of orbital occupancy. Ko et al. report an orbital-selective metal-to-insulator transition driven by Hund´s physics via symmetry-preserving strain tuning in monolayer SrRuO3.

Intramyocardial injection of synthetic mRNA coding for the embryonic T-box transcription factor 18 gene generates rate-adaptive cardiac pacing and limits innate and inflammatory immune responses, as shown in rodents and pigs.

There is significant interest in the evolution of supramolecular chirality via self-assembly of achiral building blocks. Here, the authors report a system where the supramolecular chirality can be selectively and reversibly controlled and arrested by visible and ultraviolet circularly polarized light.

Osteoblasts and endothelial cells have important roles in bone regeneration. Kim and colleagues identify the protein DJ-1 as an angiogenic and osteogenic signalling molecule involved in the cross-talk between these cells and show that DJ-1 promotes bone regeneration and fracture healing in mice.

ADHD is characterized by hyperactivity and deficits in learning and memory. Now, Eunjoon Kim and colleagues report that a polymorphism in the gene that encodes the adaptor protein GIT1 is linked to ADHD in humans. This polymorphism reduces GIT1 expression, and GIT1-deficient mice show ADHD-like behaviors that can be alleviated with the psychostimulant drugs used to treat human ADHD.

Anti-PD-1 therapy could induce a durable response in patients with gastric cancer, however biomarkers to predict response to immunotherapy are generally lacking. Here the authors report that openness of chromatin in circulating CD8⁺ T cells predicts treatment outcome in patients with metastatic gastric cancer treated with pembrolizumab.

Inspired by the art of kirigami, a haptic device based on a miniaturized electromechanical structure combined with skin as an elastic, energy-storing element demonstrates bioelastic state recovery and can be used in sensory substitution.

Most approaches to control gene expression in vivo require generation of knock-in mouse lines and often lack spatiotemporal control. Here the authors develop a photo-activatable Flp recombinase system and demonstrate its use by controlling object-exploration behavior in mice through Cav3.1 silencing.

A lightweight, flexible technology that displays vibro-tactile patterns across large areas of the skin in single units or through a wirelessly coordinated collection of them can be used to convey map directions for road navigation, translate musical tracks into tactile patterns and reconstruct tactile sensations for feedback control of robotic prosthetics.

Bilateral sensory stimulation, which is used to treat post-traumatic stress disorder in humans, alleviates fear memory in mice through a circuit involving the superior colliculus and the medial thalamus.

Optogenetic applications in the brain of live animals often require the use of optic fibers due to poor tissue-penetration of blue light. Here the authors present monSTIM1, an improved high sensitivity optogenetic tool able to modulate Ca²⁺ signaling in the brain of awake mice using non-invasive light stimulation.

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

A monolayer of tungsten oxyselenide, created by oxidizing a layer of tungsten diselenide, can be used to efficiently dope graphene, leading to a room-temperature mobility of 2,000 cm² V^–1 s^–1 at a hole density of 3 × 10¹³ cm^–2.

Persistent antigen stimulation can cause exhaustion and unresponsiveness of CD8 cells, impairing the immune response. Here the authors show that increasing the number of CD8 cells, decreasing the antigen load or providing CD4 help can overcome the exhaustion and establish a memory response.

While several human papilloma virus (HPV) vaccines exist, a highly effective vaccine that mediates regression of HPV-induced tumours is lacking. Here the authors show that a therapeutic DNA vaccine-induced HPV-specific polyfunctional CD8 T cell in 7 out of 9 patients who all exhibited complete regression of lesions and viral clearance.

Idiopathic pulmonary fibrosis (IPF) is a fatal adult lung disease. Here the authors investigate the functional significance of PDCD5 in club cells as a mediator of lung fibrosis and potential therapeutic target for IPF.

Calcium flux must be carefully controlled during the phagocytosis of apoptotic cells (efferocytosis), although how this occurs is not fully understood. Here, the authors show that the Cereblon E3 ligase regulates Orai1 degradation and subsequently SOCE-mediated calcium influx.

Prostaglandins PGE1 and PGA1 have neuroprotective effects by enhancing the transcriptional activity of Nurr1 by directly binding to its ligand-binding ___domain and upregulating their target genes implicated in Parkinson’s disease.