Nature Search

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Global impoverishment of natural vegetation revealed by dark diversity

A comparison of alpha diversity (number of plant species) and dark diversity (species that are currently absent from a site despite being ecologically suitable) demonstrates the negative effects of regional-scale anthropogenic activity on plant diversity.

Meelis Pärtel
Riin Tamme
Martin Zobel
ResearchOpen Access02 Apr 2025
Nature

Volume: 641, P: 917-924
AIDS and the new drug injector

Drug injection is one way in which human immunodeficiency virus is transmitted. Health programmes should take into account epidemiological differences between more experienced and new drug injectors.

S. R. Friedman
A. Neaigus
Susan Tross
Research01 Jun 1989
Nature

Volume: 339, P: 333-334
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

T cell responses can be generated to either pathogen infection or from priming with a vaccine. Here the authors compare T cell generation, phenotype and single cell transcriptome of participants vaccinated with a mpox vaccine or infected with the virus showing that the virus induced T cells showed more effective function and phenotype.

Ji-Li Chen
Beibei Wang
Tao Dong
ResearchOpen Access10 May 2025
Nature Communications

Volume: 16, P: 1-17
Micrograzers may affect macroalgal density

SUSAN H. BRAWLEY
WALTER H. ADEY
Research09 Jul 1981
Nature

Volume: 292, P: 177
Cost-effectiveness of natural forest regeneration and plantations for climate mitigation

It is important to understand the cost-effectiveness of natural regeneration and plantations, which are common reforestation methods for mitigation. The authors estimate and map abatement costs for the two approaches across low- and mid-income countries, helping to guide reforestation initiatives.

Jonah Busch
Jacob J. Bukoski
Jeffrey R. Vincent
ResearchOpen Access24 Jul 2024
Nature Climate Change

Volume: 14, P: 996-1002
Altered cleavage and secretion of a recombinant β–APP bearing the Swedish familial Alzheimer's disease mutation

Kevin M. Felsenstein
Lisa W. Hunihan
Susan B. Roberts
Research01 Mar 1994
Nature Genetics

Volume: 6, P: 251-256
Variability in the analysis of a single neuroimaging dataset by many teams

The results obtained by seventy different teams analysing the same functional magnetic resonance imaging dataset show substantial variation, highlighting the influence of analytical choices and the importance of sharing workflows publicly and performing multiple analyses.

Rotem Botvinik-Nezer
Felix Holzmeister
Tom Schonberg
Research20 May 2020
Nature

Volume: 582, P: 84-88
Ecological discontinuity

Susan Harrison
Books & Arts08 Nov 1990
Nature

Volume: 348, P: 123-124
Information and Data Sharing Policy, Genomic Science Program, DOE

Susan Gregurick
ResearchOpen Access19 May 2011
Nature Precedings

P: 1
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Limiting Factors in Threshold and Suprathreshold Vision

GEORGE A. HAY
M. SUSAN CHESTERS
Research19 Dec 1970
Nature

Volume: 228, P: 1216-1218
Selling neuroscience

Susan A. Greenfield
Books & Arts19 Sept 1991
Nature

Volume: 353, P: 221-222
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer

New tumor epitopes are discovered by ribosome profiling and immunopeptidome mass spectrometry.

Tamara Ouspenskaia
Travis Law
Aviv Regev
Research18 Oct 2021
Nature Biotechnology

Volume: 40, P: 209-217
Identity of some human bladder cancer cell lines

Carol M. O'Toole
Susan Povey
L. M. Franks
Research03 Feb 1983
Nature

Volume: 301, P: 429-430
Potential for low-cost carbon dioxide removal through tropical reforestation

There is a growing need to find cost-effective options for greenhouse gas abatement. In this study, spatially disaggregated marginal abatement cost curves are developed to facilitate economic appraisal of tropical reforestation.

Jonah Busch
Jens Engelmann
Priya Shyamsundar
Research27 May 2019
Nature Climate Change

Volume: 9, P: 463-466
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
Non-aqueous synthesis of giant crystals of zeolites and molecular sieves

Alex Kuperman
Susan Nadimi
Michael M. Olken
Research16 Sept 1993
Nature

Volume: 365, P: 239-242
F-actin binding site masked by the intramolecular association of vinculin head and tail domains

Robert P. Johnson
Susan W. Craig
Research19 Jan 1995
Nature

Volume: 373, P: 261-264
Reaction of mouse strains to skin test for ectromelia using an allied virus as inoculum

DAWN OWEN
AURIOL HILL
SUSAN ARGENT
Research01 Apr 1975
Nature

Volume: 254, P: 598-599
Interaction of Carcinogenic Metals with Tissue and Body Fluids

Susan M Weinzierl
M Webb
Research01 Aug 1972
British Journal of Cancer

Volume: 26, P: 279-291
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
A roadmap for affordable genetic medicines

Implementation of new pricing and business structures and improved licensing and manufacturing processes could reduce the per-patient cost of gene therapy tenfold.

Melinda Kliegman
Manar Zaghlula
Jennifer A. Doudna
Reviews17 Jul 2024
Nature

Volume: 634, P: 307-314
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
Shared heritability and functional enrichment across six solid cancers

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Xia Jiang
Hilary K. Finucane
Sara Lindström
ResearchOpen Access25 Jan 2019
Nature Communications

Volume: 10, P: 1-23
Mammal responses to global changes in human activity vary by trophic group and landscape

Analysing camera-trap data of 163 mammal species before and after the onset of COVID-19 lockdowns, the authors show that responses to human activity are dependent on the degree to which the landscape is modified by humans, with carnivores being especially sensitive.

A. Cole Burton
Christopher Beirne
Roland Kays
ResearchOpen Access18 Mar 2024
Nature Ecology & Evolution

Volume: 8, P: 924-935
Pests of Rice

SUSAN D. FEAKIN
Research06 Apr 1968
Nature

Volume: 218, P: 65-66
Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

A genome-wide association study suggests 41 previously unreported loci on top of the 23 known loci that influence the disease risk for lumbar disc herniations. Many of these loci harbour genes implicated in disc structure and inflammation, as well as genes related to the nervous system and nerve function.

Ville Salo
Juhani Määttä
Johannes Kettunen
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Co-benefits of mitigating global greenhouse gas emissions for future air quality and human health

Mitigation of greenhouse gas emissions often reduces co-emitted air pollutants, with advantages for human health. Avoided mortality from air pollution, a co-benefit of CO₂ abatement, is estimated under global climate change mitigation scenarios to be in the range of US$50–US$380 per tonne of CO₂. This exceeds the projected mitigation costs for 2030 and 2050, and is within the lower range of costs expected in 2100.

J. Jason West
Steven J. Smith
Jean-Francois Lamarque
Research22 Sept 2013
Nature Climate Change

Volume: 3, P: 885-889
Gustducin is a taste-cell-specific G protein closely related to the transducins

Susan K. McLaughlin
Peter J. McKinnon
Robert F. Margolskee
Research18 Jun 1992
Nature

Volume: 357, P: 563-569
Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

Timothy E. Adams
Susan Alpert
Douglas Hanahan
Research15 Jan 1987
Nature

Volume: 325, P: 223-228
Space science with CubeSats and nanosatellites

Recently, nanosatellite capabilities, driven by commercial and scientific innovation, have led to the development of high-performance satellite payloads and subsystems. This article reflects on the history, current state and future of the field.

J. Douglas Liddle
Antony P. Holt
Edward J. Stevens
Reviews06 Nov 2020
Nature Astronomy

Volume: 4, P: 1026-1030
In vitro hydrogen production by glucose dehydrogenase and hydrogenase

Jonathan Woodward
Susan M. Mattingly
Michael Adams
Research01 Jul 1996
Nature Biotechnology

Volume: 14, P: 872-874
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
CHD3 helicase ___domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with macrocephaly and speech and language impairment.

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

Christopher Vulpe
Barbara Levinson
Jane Gitschier
Research01 Jan 1993
Nature Genetics

Volume: 3, P: 7-13
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Ken Suzuki
Konstantinos Hatzikotoulas
Eleftheria Zeggini
ResearchOpen Access19 Feb 2024
Nature

Volume: 627, P: 347-357
Dynamics of the blood plasma proteome during hyperacute HIV-1 infection

How the human plasma proteome is altered during hyperacute HIV-1 infection remains elusive. Here, the authors profile plasma proteins in participants from sub-Saharan African countries before, during and after hyperacute infection and report differentially expressed proteins that define early host response and might serve as biomarkers.

Jamirah Nazziwa
Eva Freyhult
Joakim Esbjörnsson
ResearchOpen Access05 Dec 2024
Nature Communications

Volume: 15, P: 1-14
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Juliette Coignard
Michael Lush
Antonis C. Antoniou
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-22
Improved Imputation of Common and Uncommon Single Nucleotide Polymorphisms (SNPs) with a New Reference Set

Demetrius Albanes
Lauren Teras
Nilanjan Chatterjee
ResearchOpen Access07 Nov 2011
Nature Precedings

P: 1
Making books cheaper

SUSAN E. ABRAMS
Correspondence29 May 1980
Nature

Volume: 285, P: 282
Materiality and risk in the age of pervasive AI sensors

Sloane and colleagues review emerging new dimensions of risks associated with materiality and AI algorithms run on pervasive sensors.

Mona Sloane
Emanuel Moss
Vijay Janapa Reddi
Reviews20 Mar 2025
Nature Machine Intelligence

Volume: 7, P: 334-345
The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein

Laurie J. Ozelius
Jeffrey W. Hewett
Xandra O. Breakefield
Research01 Sept 1997
Nature Genetics

Volume: 17, P: 40-48

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