Nature Search

The impact of exercise on gene regulation in association with complex trait genetics

It is known that exercise influences many human traits, but not which tissues and genes are most important. This study connects transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium with human data to identify traits with similar tissue specific gene expression signatures to exercise.

Nikolai G. Vetr
Nicole R. Gay
Stephen B. Montgomery
ResearchOpen Access01 May 2024
Nature Communications

Volume: 15, P: 1-14
Functional assignment of multiple catabolic pathways for d-apiose

A bioinformatic strategy beginning with solute-binding proteins involved in sugar transport led to the functional annotation of four previously unknown catabolic pathways of the branched pentose d-apiose.

Michael S. Carter
Xinshuai Zhang
John A. Gerlt
Research04 Jun 2018
Nature Chemical Biology

Volume: 14, P: 696-705
Ecdysteroids: a new generic term

T. W. GOODWIN
D. H. S. HORN
T. TAKEMOTO
Correspondence09 Mar 1978
Nature

Volume: 272, P: 122
Early involvement of the bronchi in patients with malignant lymphoma

C J Gallagher
G K Knowles
T A Lister
Research01 Dec 1983
British Journal of Cancer

Volume: 48, P: 777-781
Evidence for life on Earth before 3,800 million years ago

S. J. Mojzsis
G. Arrhenius
C. R. L. Friend
Research07 Nov 1996
Nature

Volume: 384, P: 55-59
Growth differentiation factor-9 is required during early ovarian folliculogenesis

Jinwen Dong
David F. Albertini
Martin M. Matzuk
Research10 Oct 1996
Nature

Volume: 383, P: 531-535
Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp

Factor H binding protein (fHbp) is a meningococcal virulence factor and a component of vaccines against serogroup B Neisseria meningitidis. Here, the authors characterize the vaccine-elicited human antibody Fab 1A12 and present both the free and the fHbp-bound Fab 1A12 crystal structures.

Jacinto López-Sagaseta
Peter T. Beernink
Matthew J. Bottomley
ResearchOpen Access06 Feb 2018
Nature Communications

Volume: 9, P: 1-12
Betamethasone and the Rhesus Fetus: Effect on Lung Morphometry and Connective Tissue

Jeanne C Beck
Wayne Mitzner
Rachel Scott
Research01 Mar 1981
Pediatric Research

Volume: 15, P: 235-240
Dense sampling of bird diversity increases power of comparative genomics

A dataset of the genomes of 363 species from the Bird 10,000 Genomes Project shows increased power to detect shared and lineage-specific variation, demonstrating the importance of phylogenetically diverse taxon sampling in whole-genome sequencing.

Shaohong Feng
Josefin Stiller
Guojie Zhang
Research11 Nov 2020
Nature

Volume: 587, P: 252-257
Crystal structures of human ET_B receptor provide mechanistic insight into receptor activation and partial activation

Signalling through the endothelin receptor ET_B, a class A GPCR, induces nitric oxide-mediated vasorelaxation. Here the authors present the crystal structures of the human ET_B receptor bound to the peptide hormone endothelin-3 and in complex with the ET_B-selective partial agonist IRL1620 and discuss mechanistic implications for receptor activation.

Wataru Shihoya
Tamaki Izume
Osamu Nureki
ResearchOpen Access09 Nov 2018
Nature Communications

Volume: 9, P: 1-11
A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

Alterations of the mucosal microbiota, including Lactobacillus bacteria, are associated with infections caused by the fungus Candida albicans. Here, MacAlpine et al. show that some Lactobacillus strains produce a small molecule that blocks C. albicans filamentation and biofilm formation, and thus virulence, through inhibition of a fungal kinase.

Jessie MacAlpine
Martin Daniel-Ivad
Leah E. Cowen
ResearchOpen Access22 Oct 2021
Nature Communications

Volume: 12, P: 1-16
Universal DNA methylation age across mammalian tissues

This study identifies and characterizes evolutionarily conserved cytosine methylation patterns related to age across mammals and establishes pan-mammalian epigenetic clocks.

A. T. Lu
Z. Fei
S. Horvath
ResearchOpen Access10 Aug 2023
Nature Aging

Volume: 3, P: 1144-1166
The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo

H-T Zhang
P A E Scott
R Bicknell
ResearchOpen Access06 Jun 2000
British Journal of Cancer

Volume: 83, P: 63-68
Fine Needle Aspiration in the Diagnosis of Childhood Malignant Disease in Uganda

I T Magrath
Research01 Dec 1973
British Journal of Cancer

Volume: 28, P: 477-487
Erratum: Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans

Adam R Aron
Paul C Fletcher
Trevor W Robbins
Amendments and Corrections01 Dec 2003
Nature Neuroscience

Volume: 6, P: 1329
Immune control of HIV-1 after early treatment of acute infection

Eric S. Rosenberg
Marcus Altfeld
Bruce D. Walker
Research28 Sept 2000
Nature

Volume: 407, P: 523-526
771 COMPARATIVE IMMUNOGENICITY OF GROUP C NEISSERIA MENINGITIDIS VARIANTS AND ESCHERICHIA COLI K92 CAPSULAR POLYSACCHARIDES IN ADULT VOLUNTEERS

Mary P Glode
Edward Lewin
John B Robbins
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 492
MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation

Marichal and colleagues use a model of niche depletion and refilling to show that engrafted Ly6C⁺ classical monocytes proliferate locally in a Csf1 receptor-dependent manner before differentiating into lung interstitial macrophages.

Domien Vanneste
Qiang Bai
Thomas Marichal
ResearchOpen Access16 Mar 2023
Nature Immunology

Volume: 24, P: 827-840
Crevasse refreezing and signatures of retreat observed at Kamb Ice Stream grounding zone

Observations from a remotely operated underwater vehicle reveal crevasse refreezing and the fine-scale variability in ice and ocean structure at the Kamb Ice Stream grounding line in West Antarctica.

J. D. Lawrence
P. M. Washam
B. E. Schmidt
ResearchOpen Access02 Mar 2023
Nature Geoscience

Volume: 16, P: 238-243
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Hand grip strength as a proxy of muscular fitness is a clinical predictor of mortality and morbidity. In a large-scale GWA study, the authors find 16 robustly associated genetic loci that highlight roles in muscle fibre structure and function, neuronal maintenance and nervous system signal transduction.

Sara M. Willems
Daniel J. Wright
Robert A. Scott
ResearchOpen Access12 Jul 2017
Nature Communications

Volume: 8, P: 1-12
Identification of patient-specific CD4⁺ and CD8⁺ T cell neoantigens through HLA-unbiased genetic screens

Patient-specific tumor neoantigens are recognized by T cells.

Chiara M. Cattaneo
Thomas Battaglia
Wouter Scheper
ResearchOpen Access02 Jan 2023
Nature Biotechnology

Volume: 41, P: 783-787
Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans

Adam R. Aron
Paul C. Fletcher
Trevor W. Robbins
Research21 Jan 2003
Nature Neuroscience

Volume: 6, P: 115-116
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Stabilization of an active and inactive conformation of the β₂-adrenergic receptor by allosteric nanobodies reveals differential ligand-dependent regulation of receptor states to control G-protein-coupled receptor activation.

Dean P. Staus
Ryan T. Strachan
Robert J. Lefkowitz
Research13 Jul 2016
Nature

Volume: 535, P: 448-452
Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish

Peter E Bayliss
Kimberly L Bellavance
Joanne Chan
Research26 Mar 2006
Nature Chemical Biology

Volume: 2, P: 265-273
A nonviral minicircle vector for deriving human iPS cells

Simple minicircle vectors carrying four reprogramming factors induce pluripotency in adult human adipose stem cells and in neonatal fibroblasts without integration into the genome.

Fangjun Jia
Kitchener D Wilson
Joseph C Wu
Research07 Feb 2010
Nature Methods

Volume: 7, P: 197-199
Author Correction: Universal DNA methylation age across mammalian tissues

A. T. Lu
Z. Fei
S. Horvath
Amendments and CorrectionsOpen Access06 Sept 2023
Nature Aging

Volume: 3, P: 1462
Candidalysin is a fungal peptide toxin critical for mucosal infection

This study identifies a cytolytic peptide toxin in the opportunistic human fungal pathogen Candida albicans—the peptide is both a crucial virulence factor that permeabilizes the host cell plasma membrane and a key signal that triggers a host danger response pathway.

David L. Moyes
Duncan Wilson
Julian R. Naglik
Research30 Mar 2016
Nature

Volume: 532, P: 64-68
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

Cas5 is a transcriptional regulator of responses to cell wall stress in the fungal pathogen Candida albicans. Here, Xie et al. show that Cas5 also modulates cell cycle dynamics and responses to antifungal drugs.

Jinglin L. Xie
Longguang Qin
Leah E. Cowen
ResearchOpen Access11 Sept 2017
Nature Communications

Volume: 8, P: 1-18
Addendum: A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

Jessie MacAlpine
Martin Daniel-Ivad
Leah E. Cowen
Amendments and CorrectionsOpen Access01 Aug 2024
Nature Communications

Volume: 15, P: 1
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome

J.D. Carpten
C.M. Robbins
M.R. Hobbs
Research18 Nov 2002
Nature Genetics

Volume: 32, P: 676-680
Parainfluenza Virus Immunization: II. The Influence of Age and Maternal Antibody upon Successful Immunization with an Alum-Adsorbed Parainfluenza Type 3 Vaccine

V A Fulginti
O F Sieber Jr.
H J Umlauf Jr
Research01 Jan 1967
Pediatric Research

Volume: 1, P: 50-58
Logic in Practice

T. G.
Books & Arts08 Sept 1934
Nature

Volume: 134, P: 344
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1

J. Carpten
N. Nupponen
J. Trent
Research22 Jan 2002
Nature Genetics

Volume: 30, P: 181-184
The formation of Charon’s red poles from seasonally cold-trapped volatiles

The unusual dark red coloration of Charon’s northern polar cap is shown to be produced from hydrocarbons that are cold-trapped from Pluto’s escaping atmosphere during winter.

W. M. Grundy
D. P. Cruikshank
A. M. Zangari
Research14 Sept 2016
Nature

Volume: 539, P: 65-68
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

The X-ray crystal structure of the M2 muscarinic acetylcholine receptor, which is essential for the physiological control of cardiovascular function, is reported.

Kazuko Haga
Andrew C. Kruse
Takuya Kobayashi
Research25 Jan 2012
Nature

Volume: 482, P: 547-551
The History of Pediatric Infectious Diseases

Stanford T Shulman
Research01 Jan 2004
Pediatric Research

Volume: 55, P: 163-176
Consensus, common entry, and community curation

David T. Kingsbury
Comments & Opinion01 Jun 1996
Nature Biotechnology

Volume: 14, P: 679-680
Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth

Zuzana Biesova
Claudia Piccoli
William T Wong
Research16 Jan 1997
Oncogene

Volume: 14, P: 233-241
Salmon provides fast and bias-aware quantification of transcript expression

Salmon is a computational tool that uses sample-specific models and a dual-phase inference procedure to correct biases in RNA-seq data and rapidly quantify transcript abundances.

Rob Patro
Geet Duggal
Carl Kingsford
Research06 Mar 2017
Nature Methods

Volume: 14, P: 417-419
Psychopharmacology handbook

T. J. Crow
Books & Arts01 Feb 1979
Nature

Volume: 277, P: 674-675
Neurophysiology: Trophic factors and postsynaptic activity in synapse formation

T. Lømo
News & Views13 Oct 1983
Nature

Volume: 305, P: 576
Meeting the Crisis in Mathematical Teaching

T. A. A. BROADBENT
Books & Arts10 Mar 1962
Nature

Volume: 193, P: 912-913
A plan for mental illness

The Royal Society International Seminar Consortium describes what the next decade of mental-health drug development should look like.

Thomas R. Insel
Barbara J. Sahakian
John H. Williams
Comments & Opinion14 Mar 2012
Nature

Volume: 483, P: 269
Microsatellite instability and promoter methylation as possible causes of NF1 gene inactivation in neurofibromas

Mirjam Luijten
Sandra Redeker
Theo JM Hulsebos
Research20 Dec 2000
European Journal of Human Genetics

Volume: 8, P: 939-945
Chromosomal rearrangements, speciation and the theoretical approach

Max King
Research01 Aug 1987
Heredity

Volume: 59, P: 1-6
Chronic Obstructive Pulmonary Disease: Evidence for an Autoimmune Component

Anna M Stefanska
Patrick T Walsh
Reviews01 Apr 2009
Cellular & Molecular Immunology

Volume: 6, P: 81-86
Reorientation of Sputnik Planitia implies a subsurface ocean on Pluto

To explain the position of the Sputnik Planitia basin on Pluto, the feature would need to have formed via impact and Pluto would need to have a subsurface ocean.

F. Nimmo
D. P. Hamilton
K. E. Smith
Research16 Nov 2016
Nature

Volume: 540, P: 94-96
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

Microscopic imaging of neurons in mouse models of Alzheimer’s disease shows that plaques increase activity while neurofibrillary tangles suppress activity. The combination of plaques and tangles, as in humans with Alzheimer’s disease, suppresses activity.

Marc Aurel Busche
Susanne Wegmann
Bradley T. Hyman
Research17 Dec 2018
Nature Neuroscience

Volume: 22, P: 57-64
Nanoimmunotherapy to treat ischaemic heart disease

Over the past 20 years, new insights into cardiovascular immunopathology have shifted the therapeutic focus from lipids to inflammation. In this Review, Duivenvoorden and colleagues discuss recent discoveries in the immunopathology of atherosclerosis, advances in bioengineering techniques, and how these advances have guided the development of innovative nanoimmunotherapeutic strategies to modulate immune responses in cardiovascular disease.

Raphaël Duivenvoorden
Max L. Senders
Willem J. M. Mulder
Reviews12 Sept 2018
Nature Reviews Cardiology

Volume: 16, P: 21-32
Basis of Intelligence

A. T. WELFORD
Books & Arts11 Mar 1967
Nature

Volume: 213, P: 972

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