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The Rubicon–WIPI axis regulates exosome biogenesis during ageing

Yanagawa et al. show that the autophagy-related protein Rubicon recruits WIPI2d to endosomes to promote exosome biogenesis. Rubicon promotes both an increase in exosome release during ageing and the pro-senescent effects of these exosomes.

Kyosuke Yanagawa
Akiko Kuma
Tamotsu Yoshimori
Research22 Aug 2024
Nature Cell Biology

Volume: 26, P: 1558-1570
Rapid and Integrated Bacterial Evolution Analysis unveils gene mutations and clinical risk of Klebsiella pneumoniae

Authors develop and present RIBEA (Rapid and Integrated Bacterial Evolution Analysis), an approach that combines lab-based evolution experiments, genome sequencing and in vivo testing, to monitor long-term evolution or bacterial pathogenicity and antimicrobial resistance, in the context of Klebsiella pneumoniae.

Kojiro Uemura
Toyotaka Sato
Shin-ichi Yokota
ResearchOpen Access25 Mar 2025
Nature Communications

Volume: 16, P: 1-17
Leucine-rich Alpha-2 glycoprotein could be clinically useful in active and postoperative Crohn’s disease

Taku Tashiro
Shinichiro Shinzaki
Tetsuo Takehara
ResearchOpen Access16 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
Monumental architecture at Aguada Fénix and the rise of Maya civilization

Lidar survey of the Maya lowlands uncovers the monumental site of Aguada Fénix, which dates to around 1000–800 bc and points to the role of communal construction in the development of Maya civilization.

Takeshi Inomata
Daniela Triadan
Hiroo Nasu
Research03 Jun 2020
Nature

Volume: 582, P: 530-533
Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease

Kenichiro Iio
Daijiro Kabata
Yutaka Ando
ResearchOpen Access28 Jan 2019
Scientific Reports

Volume: 9, P: 1-8
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Here, the authors identify six risk SNPs for systemic sclerosis by performing GWAS on Japanese patients and meta-analyzing Japanese and European GWAS datasets. Downstream analyses indicate that B cells contribute to pathogenesis.

Yuki Ishikawa
Nao Tanaka
Chikashi Terao
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients

Suguru Yamamoto
Junichiro J. Kazama
Ichiei Narita
ResearchOpen Access23 Sept 2015
Scientific Reports

Volume: 5, P: 1-8
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
A biomolecular anthropological investigation of William Adams, the first SAMURAI from England

Fuzuki Mizuno
Koji Ishiya
Shintaroh Ueda
ResearchOpen Access10 Dec 2020
Scientific Reports

Volume: 10, P: 1-7
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries

Tetsuya Yumoto
Takafumi Obara
Tamotsu Gotou
ResearchOpen Access12 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
Fresh litter acts as a substantial phosphorus source of plant species appearing in primary succession on volcanic ash soil

Sae Katayama
Takayuki Omori
Masaki Tateno
ResearchOpen Access01 Jun 2021
Scientific Reports

Volume: 11, P: 1-10

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The Rubicon–WIPI axis regulates exosome biogenesis during ageing

Rapid and Integrated Bacterial Evolution Analysis unveils gene mutations and clinical risk of Klebsiella pneumoniae

Leucine-rich Alpha-2 glycoprotein could be clinically useful in active and postoperative Crohn’s disease

Monumental architecture at Aguada Fénix and the rise of Maya civilization

Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease

GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients

Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

A biomolecular anthropological investigation of William Adams, the first SAMURAI from England

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries

Fresh litter acts as a substantial phosphorus source of plant species appearing in primary succession on volcanic ash soil

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