Search

APOL9a/b proteins coat mouse intestinal bacteria with high specificity, and genetic abolition of ceramide-1-phosphate synthesis pathways in the symbiote Bacteroides thetaiotaomicron significantly decreases this binding of APOL9a/b to the bacterium.

The sluggish conversion of lithium polysulfides in Li–S batteries can be overcome by the use of catalysts, but their design is typically done via trial and error. Now, a binary descriptor is proposed by machine learning to capture electronic and structural effects for the design of Li–S battery cathode catalysts.

Diffractive imaging of an important class of battery electrodes during cycling shows that lattice strain is a crucial yet overlooked factor that contributes to voltage fade over time.

Fa-Cheng Wang and colleagues propose a conceptual hybrid design for submerged floating tunnels (SFTs) that considerably improves resistance to harsh service conditions. This adaptable and cost-effective solution advances SFT practical implementation.

Copolymerization with cleavable comonomers is a versatile approach to generate vinyl polymer with a viable end-of-life option. Here, the authors show that an anion binding catalyst seleno cyclodiphosph(V)azanes enables the efficient cationic copolymerization with cyclic acetals by reversibly activate both different dormant species to achieve both high living chain end retention and high molecular weight.

An asteroseismic and spectroscopic analysis of lithium-rich stars improves their classification based on the distributions of lithium, nitrogen and mass, and reveals that most of these evolved stars are red clump rather than red giant branch stars.

Nanopore direct RNA sequencing is promising for epitranscriptome study but remains limited in single-molecule resolution. Here, the authors develop SingleMod, a tool for accurate single-molecule m6A detection from DRS and reveal cross-species epitranscriptome landscapes at single-molecule level.

Electrolyte design is crucial for lithium metal battery development. Here the authors report an electrolyte with a compact solvation structure on the nanometre scale that facilitates fast interfacial reaction kinetics and improves battery performance.

The core circadian transcription factor BMAL1 regulates circadian-dependent myocardial injury.

A new deep learning-based global medium-range weather forecasting model outperforms existing machine learning models and the European Centre for Medium-Range Weather Forecasts model, producing accurate global weather forecasts beyond ten days.

The antiviral dsRNA sensor PKR is regulated by PACT. This paper shows how PACT prevents aberrant PKR activation by endogenous dsRNAs like Alu. PACT disrupts PKR’s dsRNA scanning without blocking its binding, resetting its activation threshold to tolerate cellular dsRNA and preserve homeostasis.

ESM-Ezy combines the ESM-1b protein language model with similarity analysis to predict enzymatic functions in low-similarity sequences. It identifies high-performance biocatalysts, such as novel multicopper oxidases and L-asparaginases, with enhanced efficiency, stability, and industrial potential, advancing sustainable biotech solutions.

A fluorinated electrolyte forms a few-nanometre-thick interface both at the anode and the cathode that stabilizes lithium-metal battery operation with high-voltage cathodes.

The use of energy-dense materials is inherently limited in biphasic self-stratified batteries due to the aqueous electrolyte environment. Here, the authors extended the concept of biphasic self-stratified batteries to non-aqueous systems, resulting in increased energy density and output voltage.

The CAPItello-291 phase 3 study reported that capivasertib (an AKT inhibitor) and fulvestrant (a selective estrogen receptor degrader) improved progression free survival in patients with HR-positive/HER2-negative advanced breast cancer. Here, the authors report the results of an extended Chinese cohort recruited as part of the original global CAPItello-291 study.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and electron microscopy, tissue clearing and time-lapse super-resolution microscopy.

Drought, fires, and human activities have reversed the accumulation of live biomass carbon in the Northern Hemisphere, with total biomass shifting from a positive to a negative trend around 2016.

Gold redox catalysis is an attractive synthetic method but challenging due to the high redox potential of Au(I)/Au(III). Now, a bidentate N-ligand-assisted gold redox catalysis using H₂O₂ as oxidant has been developed. It can be applied to various coupling reactions, including C(sp)–C(sp) cross-coupling, alkynylative cyclization and bicyclization coupling.

Robbins and colleagues show that cigarette smoke-induced endothelial dysfunction enables atherosclerotic plaque macrophages to drive abdominal aortic aneurysm formation in a mouse model of atherosclerosis.

Climate oscillations, such as El Niño/Southern Oscillation (ENSO), play a key role in global and regional crop yield variations. The authors analysed crop yield data in China from 1980 to 2017 and found that ENSO affects yield not only through local climate variability but also by driving migratory crop pest outbreaks, highlighting an overlooked pathway by which ENSO drives yield loss.

Meta-learning-empowered reflective lattice light-sheet virtual structured illumination microscopy (Meta-rLLS-VSIM) offers near-isotropic resolution for fast and versatile super-resolution imaging of subcellular dynamics

Here the authors introduce the concept of adiabatic infimum in the topological pumping process using lithium niobate-on-insulator waveguides, exceeding the limitations of conventional pumps. These results will facilitate the design of compact topological devices.

The lithium metal is a promising anode material for batteries; however, the growth of dendrite and its instability against moisture are two technical challenges. Here the authors address both issues by introducing a bifunctional layer consisting of hydrophobic graphite fluoride and lithium fluoride.

A pangenome of wild and cultivated rice accessions captures the entire set of non-redundant genes and diversity in rice, and provides insights into the pathways involved in the evolution of rice.

ATLAS is a tool for circuit tracing, demonstrated here in rodents. It allows anterograde transsynaptic tracing, starting from genetically defined neurons.

While CDK4/6 inhibitors have become standard of care in patients with HR+/HER2- advanced breast cancer (ABC), selecting the optimal inhibitor could improve care further. Here, the authors report planned interim analysis of the BRIGHT-2 study, a randomised phase 3 trial comparing bireociclib (CDK4/6i) and fulvestrant (ET) against placebo and fulvestrant in female HR + /HER2- ABC patients.

Instability is a key challenge in aqueous sodium-ion batteries. Here, authors propose a Na-rich birnessite with high Na content and minimal Mn defects, suppressing Mn migration and its accompanying domino degradation effect, which enables a wide potential window and improved structural stability.

Polysubstituted arenes are ubiquitous structural cores in natural products and drugs but their synthesis through programmable arene modification remains a challenge. Now, a palladium- and norbornene-catalysed Catellani-type reaction of aryl ketones, through successive acylation and deacylation, allows the synthesis of polysubstituted arenes.

The molecular mechanisms underlying the function of different cellular states in glioblastoma stem cells (GSCs) remain poorly understood. Here, the authors perform integrated single cell and bulk analysis of GSCs and identify potential therapeutic targets.

The authors demonstrate an on-chip metasurface based on supercell scheme to enable full modulation of Jones matrix. The direction-multiplexed functionality has been implemented by joint control of detour phase, geometric phase and propagation phase, unlocking two independent sets of Jones matrices.

Qui et al. perform co-detection by indexing profiling of 401 hepatocellular carcinoma patient samples and identify a role for vimentin^high macrophages in instructing an immune-suppressive microenvironment by enhancing the suppressive activity of regulatory T cells via interleukin-1β.

To fulfill the great promise of Li-O₂ batteries, the high charge overpotential is a major challenge that has to be addressed. Here the authors introduce triethylsulfonium iodide as a redox mediator as well as an enabler of a protective layer on Li anode, leading to notable electrochemical performance.

Human-machine collaboration in noisy environments using conventional microphones remains challenging. Here, the authors develop an anti-noise triboelectric acoustic sensor integrated with a CNN-based deep learning model to facilitate complex human-machine tasks in highly noisy conditions.

In this study, Leventhal et al. integrate multi-omic data from human and Drosophila models of Alzheimer’s disease to define regulators of age-associated neurodegeneration in Alzheimer’s disease and the pathways through which they act.

The instability of quantum dot inks hinders the scaling up of colloidal quantum dot electronics. Now, Shi and team stabilize the inks with an iodine-rich environment in a weakly coordinating solvent, achieving 13.4% in small-area solar cells and over 10% in modules.