Search

The realization of high-performance flexible perovskite/crystalline-silicon tandem solar cells requires efficient photocarrier transport and mitigation of residual stress. Here, authors reveal the critical role of perovskite phase homogeneity, achieving flexible devices with efficiency of 29.88%.

Parasitoid wasps are reared and released as biocontrol agents to manage aphids and protect crops. Here, the authors use genomes from 542 wasps to show that, in spite of wide scale release of low-diversity captive individuals, diversity in wild populations is maintained.

Zhang et al. show that YAP binds to TDP-43 to promote TDP-43 multimerization and phase separation. YAP and TDP-43 may co-localize in multiple cell types in oxidative stress and in brain samples from individuals with amyotrophic lateral sclerosis.

Enabled by imprint field, the authors achieve flexoelectric switching in thin ferroelectrics with millisecond low-force pulses. A mechanically gated transistor with nonvolatile, multi-level states shows promise for tactile-sensing applications.

Adoptive transfer of regulatory T (Treg) cells holds promise for the treatment of inflammatory diseases, but maintaining a therapeutic capacity is challenging. Here, the authors show that engineering Tregs to express an IL-2 partial agonist enhances Treg persistence and suppression of inflammation in mouse models, representing a potential optimization for Treg therapy.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

In this Analysis, Liu et al. benchmark more than 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure–function coupling and behavior prediction, revealing varying effectiveness for specific neurophysiological applications.

Single-atom catalysts commonly present a random distribution of the active metal centres. Now a series of Mg-rich intermetallic compounds is introduced to enable ordered dispersed active metals. Furthermore, a cascade process is demonstrated on Mg₂₉Pd_1.3Rh_2.7, where Pd sites catalyse the semihydrogenation of phenylacetylene with subsequent hydroformylation on Rh sites.

The uneven surfaces of copper indium gallium selenide (CIGS) solar cells pose challenges for depositing the upper layers in flexible perovskite/CIGS tandem solar cells. Ying et al. tackle this issue using an antisolvent and seeding strategy, resulting in a certified efficiency of 23.8%.

Targeted multielement substitution of a lead-free relaxor ferroelectric perovskite distorts the lattice structure and induces strong polar disorder, leading to high-polar-entropy ferroelectric oxides with a high electrocaloric effect and long lifetime.

The impact of land-use and cover-change (LUCC) on ecosystem carbon stock in China is poorly known due to large biases in existing databases. Here the authors develop a new LUCC database with corrected false signals and reveal that forest expansion is the dominant driver of China’s recent carbon sink.

A nanoporous photocatalyst producing low levels of hydrogen peroxide is shown to modulate intracellular stress granules, enhancing resilience against oxidative stress and providing cardioprotection in an ex vivo rodent model of myocardial ischaemia–reperfusion injury.

The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in stereotyped neuronal circuits.

International export accounted for up to ten percent of particulate matter pollution in China in 2017, according to combined atmospheric and economic model analysis.

HIV reservoir dynamics are still incompletely understood. Here, the authors use barcoded HIV in a humanized mouse model to show that cell clones linked to viremia are likely eliminated, while proliferated cell clones contribute to viremia, are likely more resistant to elimination and might fuel viral persistence.

Reactive capture—integrating CO₂ capture and electrochemical valorization—improves energy efficiency by eliminating gas-phase CO₂ desorption. Here, authors design a redox-active polymeric network to boost the direct conversion of captured CO₂ to multicarbon products with CO₂-free gas product stream.

Glycosylated asparagine residues that mediate the function of the B7H3 protein are unclear. Here the authors identify the important N-glycosylation sites for B7H3 cell surface localization and T cell inhibition, followed by the development of N91/309 and N104/322 preferentially targeting monoclonal antibody manifesting enhanced antitumor immunity.

The recent experimental creation of magnetic skyrmions, topologically protected particle-like spin textures, has inspired proposals for their application in nanodevices. Here, the authors use Lorentz transmission electron microscopy to demonstrate edge-mediated skyrmion chain formation in FeGe nanostripes.

High-quality genome of the modern soybean cultivar Nongdadou2 and deep resequencing of 547 accessions provide insights into the role of structural variations in soybean improvement.

Here, Ma et al. investigate the translational profile of cardiac regeneration, pointing to Nat10 as a key regulator of cardiomyocyte proliferative potential, and describing how it regulates cardiac gene expression.

The performance of n-i-p perovskite-organic tandem solar cells is hampered by non-ideal interconnection layers. This study reports an optimized metal-based interconnection stack featuring high transparency and efficient carrier recombination, achieving 25.34% efficiency and improved stability in tandems.

Phenotypic and genomic analyses of 215 Rosa accessions reveal the genomic foundations of phylogeny, domestication and evolutionary history of Rosa, providing insights and resources for harnessing wild germplasm in modern rose breeding.

A multi-level ordered structure strategy mimicking biological multi-structural features, concurrently unlocks multiple physical property limits. This new paradigm transcends traditional compositional design strategies to break performance bottleneck.

Immunoengineering-based cancer therapies have huge potential. Here the authors report on the lipid nanoparticle delivery, to cancer cells, of self-amplifying RNA encoding SARS-CoV-2 spike epitope-loaded MHC I molecules to take advantage of anti-SARS-CoV-2 immunity from a vaccinated population to treat cancer.

A telomere-to-telomere genome assembly of the elite Gossypium hirsutum variety ZM113 provides insights into upland cotton short-season adaptation and identifies a repositioned, satellite repeat-rich centromere.

The limited solubility, inherent chemical stability, and low reactivity of inorganic phosphates pose hinder their conversion into organophosphates under mild conditions. Here, the authors report a method for the direct conversion of phosphates into P(V)-X reagents via a redox-neutral halogenation process, using cyanuric chloride or cyanuric fluoride as the halogenation reagent.

Ferroptosis and pyroptosis are emerging regulated forms of cell death promising for cancer therapy. Here this group reports fabricating folic acid and croconaine functionalized upconversion nanoparticles for mobilizing intracellular stores of endogenous iron, and spatiotemporally controlling lysosome-intrinsic Fenton chemistry, thereby triggering lysosomal membrane permeabilization-associated ferroptosis and pyroptosis dual-induction.

Olfactory second-order conditioning is supported by the posterior piriform cortex–basolateral amygdala circuit, characterized by overlapping gene regulation profiles and distinct chromatin remodeling in pyramidal neurons.

Knock-in mice conditionally or constitutively expressing Cas12 variants enable a wide range of ex vivo and in vivo applications requiring multiplexed genome engineering.

Hybrid necrosis in wheat is caused by the complementary genes Ne1 and Ne2. The underlying mechanism remains enigmatic. Here, Si et al. demonstrated that a genetic interaction between the α/β hydrolase (Ne1) and the NLR immune receptor (Ne2) triggers autoimmune responses, inducing hybrid necrosis.

A simple method combining thermal activation and electric fields is demonstrated to efficiently generate ordered vacancies in bulk metal oxides, which can be used for broad applications.

A lipid-nanoparticle-based formulation incorporating engineered lipids containing a blood–brain-barrier-crossing moiety effectively delivers mRNA to neurons and astrocytes following systemic administration in mice.

Observation-based extreme precipitation-temperature sensitivities reveal increases in heavy rainfall across continents after adjusting for cloud-radiative effects, consistent with changes in atmospheric moisture with global warming.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

The development of nanocarriers for targeted protein delivery requires methods for high-throughput screening in vitro and in vivo. Here authors develop a DNA-barcoded method to identify nanocarriers with different biodistributions, and demonstrate delivery of catalase to the kidneys of female mice, successfully mitigating cisplatin-induced acute kidney injury.

Stable manipulation of polar skyrmions is challenging because of the underlying competitive energy scales. Now thermal excitation has been demonstrated to be an effective way to control such topological states.

A tunable terahertz radiation pulse is demonstrated based on a linear accelerator. The emission frequency of this terahertz radiation is tunable from 1 to 10 THz by changing the bunching frequency of a 34 MeV electron beam. The pulse energy is at the submillijoule level.

Graphene has demonstrated the ability to modulate terahertz (THz) waves by optical or electrical excitation, but modulation depths have been low. Here, Li et al. demonstrate enhanced modulation and polarity-dependent THz attenuation using external voltage bias and photoexcitation on a graphene–silicon film.

Quantum dots with a fine size dispersion offer attractive levels of functional control and manipulation. In this study, Yang et al. report an environmentally friendly top–down synthesis technique, based on laser irradiation of a polydisperse of lead sulphide nanocrystals.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Traditional water–gas shift reaction process is hindered by harsh reaction conditions and extra steps for hydrogen separation and purification. Here, the authors report a room temperature electrochemical water–gas shift process for direct production of high purity hydrogen with a faradaic efficiency of approximately 100%.

Protomelission-like macrofossils from the Xiaoshiba Lagerstätte show features characteristic of dasycladalean green alga, suggesting that Protomelission is unlikely to be an early bryozoan.

LC-MS-based proteomics often relies on data-dependent acquisition (DDA) for quality control. Here, the authors demonstrate that data-independent acquisition (DIA) outperforms DDA in detecting subtle changes in LC-MS status in large-scale quantitative proteomics experiments. They further prioritized 15 QC metrics and developed an AI model, implemented in a free software called iDIA-QC, for detecting LC-MS faults.

Comparing spatial omics data across samples remains elusive. Here, the authors develop a quantitative spatial framework, termed as colocatome analysis, by combining pairwise cell-cell colocalization, spatial permutation and normalization approaches for comparing features across conditions and studies.

One of the possible forms of dark energy is symmetron dark energy, which theoretically interacts with matter via a fifth force. Here a magnetically levitated force sensor is used in an experiment to substantially constrain the phase space of the symmetron field.