Here it is shown that Hedgehog signalling is important in chronic myeloid leukaemia (CML), where it acts to maintain leukaemia stem cells by regulating the expression of Numb. CML stem cells can be depleted when Hedgehog signalling is inhibited, including cells that are resistant to the drug imatinib that is used to treat CML.
- Chen Zhao
- Alan Chen
- Tannishtha Reya
