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Diagnosis of diabetes without oral glucose tolerance test is associated with increased mortality in older adults

Chia-Hung Lin
Kang-Chih Fan
Hung-Yuan Li
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer

Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and increases tumour killing by γδ T cells.

Rueyhung R. Weng
Hsuan-Hsuan Lu
Hsing-Chen Tsai
ResearchOpen Access12 Apr 2021
Nature Communications

Volume: 12, P: 1-18
Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype

Chen et al. probe the role of a genotoxin of Salmonella typhi in triggering a senescence-associated secretory phenotype, via mitochondrial DNA damage.

Han-Yi Chen
Wan-Chen Hsieh
Shu-Jung Chang
ResearchOpen Access30 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Shoulder transcutaneous electric nerve stimulation decreases heart rate via potentiating vagal tone

Chun-Ming Hsieh
Wan-Chen Lin
Tzer-Bin Lin
ResearchOpen Access27 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
Membrane-protein binding measured with solution-phase plasmonic nanocube sensors

Silica-coated silver nanocube suspensions provide an easy, rapid and label-free way to quantify protein binding to supported lipid bilayers by localized plasmon resonance measurement with a standard laboratory UV spectrophotometer.

Hung-Jen Wu
Joel Henzie
Jay T Groves
Research21 Oct 2012
Nature Methods

Volume: 9, P: 1189-1191
Relationship between genotype, phenotype, and refractive status in patients of inherited retinal degeneration

Wan-Chen Tsai
Yao-Lin Liu
Ta-Ching Chen
Research02 Aug 2024
Eye

Volume: 38, P: 3301-3308
Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regulator PHD2.

Ting-Fang Chou
Ya-Ting Chuang
Ming-Zong Lai
ResearchOpen Access17 Jun 2016
Nature Communications

Volume: 7, P: 1-14
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo

Foxp3, a key transcription factor of regulatory T cells, is targeted to degradation by HIF-1α. Here the authors show that Deltex1 promotes degradation of HIF-1α, thus stabilizing Foxp3 levels and function of regulatory T cells in vivo.

Huey-Wen Hsiao
Tzu-Sheng Hsu
Ming-Zong Lai
ResearchOpen Access19 Feb 2015
Nature Communications

Volume: 6, P: 1-12
Defective Phosphatidylinositol 3-Kinase Signaling in Central Control of Cardiovascular Effects in the Nucleus Tractus Solitarii of Spontaneously Hypertensive Rats

Michael Hsiao
Pei-Jung Lu
Ching-Jiunn Tseng
Research01 Jun 2008
Hypertension Research

Volume: 31, P: 1209-1218
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

How glutamine metabolism orchestrates macrophage activation is unclear. Ho and colleagues show glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming.

Pu-Ste Liu
Haiping Wang
Ping-Chih Ho
Research17 Jul 2017
Nature Immunology

Volume: 18, P: 985-994
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells

XLP-2 syndrome is caused by XIAP mutation. Here the authors show that mouse and human XIAP-deficient regulatory T cells have defective suppressive function as a result of conversion to proinflammatory cytokine producing cells, an effect that can be prevented by blocking the IL-6 receptor.

Wan-Chen Hsieh
Tzu-Sheng Hsu
Ming-Zong Lai
ResearchOpen Access31 Jan 2018
Nature Communications

Volume: 9, P: 1-15
IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury

Wei-Yu Chen
Jenq-Lin Yang
Ya-Jen Chang
ResearchOpen Access20 Apr 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-11
New-onset diabetes mellitus risk associated with concurrent autonomous cortisol secretion in patients with primary aldosteronism

Vin-Cent Wu
Chieh-Kai Chan
Vin-Cent Wu
Research08 Dec 2022
Hypertension Research

Volume: 46, P: 445-455
Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression

Pei-Chi Tu
Wan-Chen Chang
Mu-Hong Chen
ResearchOpen Access06 Jul 2024
Molecular Psychiatry

Volume: 30, P: 61-68
Candida albicans Dbf4-dependent Cdc7 kinase plays a novel role in the inhibition of hyphal development

Wei-Chung Lai
Tschen-wei Chang
Jia-Ching Shieh
ResearchOpen Access20 Sept 2016
Scientific Reports

Volume: 6, P: 1-13
Reduced synchronized brain activity in schizophrenia during viewing of comedy movies

Pei-Chi Tu
Tung-Ping Su
Fa-Hsuan Lin
ResearchOpen Access04 Sept 2019
Scientific Reports

Volume: 9, P: 1-11
A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes

Jin-Ying Lu
Horng-Yih Ou
Lee-Ming Chuang
ResearchOpen Access15 Feb 2023
Scientific Reports

Volume: 13, P: 1-10
Exposure to tobacco smoke and childhood rhinitis: a population-based study

Tsung-Chieh Yao
Su-Wei Chang
Jing-Long Huang
ResearchOpen Access16 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Recent progress in unraveling cardiovascular complications associated with primary aldosteronism: a succinct review

Wei-Ting Wang
Tsung-Hui Wu
Vin-Cent Wu
Reviews16 Jan 2024
Hypertension Research

Volume: 47, P: 1103-1119

Search

Diagnosis of diabetes without oral glucose tolerance test is associated with increased mortality in older adults

Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer

Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype

Shoulder transcutaneous electric nerve stimulation decreases heart rate via potentiating vagal tone

Membrane-protein binding measured with solution-phase plasmonic nanocube sensors

Relationship between genotype, phenotype, and refractive status in patients of inherited retinal degeneration

Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo

Defective Phosphatidylinositol 3-Kinase Signaling in Central Control of Cardiovascular Effects in the Nucleus Tractus Solitarii of Spontaneously Hypertensive Rats

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells

IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury

New-onset diabetes mellitus risk associated with concurrent autonomous cortisol secretion in patients with primary aldosteronism

Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression

Candida albicans Dbf4-dependent Cdc7 kinase plays a novel role in the inhibition of hyphal development

Reduced synchronized brain activity in schizophrenia during viewing of comedy movies

A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes

Exposure to tobacco smoke and childhood rhinitis: a population-based study

Recent progress in unraveling cardiovascular complications associated with primary aldosteronism: a succinct review

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