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Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro

Here the authors described the structure-based design of novel, selective RIPK3 inhibitors that do not induce on-target apoptosis by occupying a unique hydrophobic site and locking RIPK3 into an inactive conformation.

Haixia Su
Guofeng Chen
Yechun Xu
ResearchOpen Access08 May 2025
Nature Communications

Volume: 16, P: 1-15
De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS

In this work, authors design novel protein condensation inhibitors (PCIs) targeting an allosteric site of cGAS, blocking DNA interactions and phase separation to suppress immune activation, and demonstrate therapeutic potential in inflammatory disease models.

Wenfeng Zhao
Guofeng Chen
Yechun Xu
ResearchOpen Access03 Jun 2025
Nature Communications

Volume: 16, P: 1-20
Correction: Corrigendum: Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li
Chuan Huang
Ge Shan
Amendments and Corrections06 Feb 2017
Nature Structural & Molecular Biology

Volume: 24, P: 194
Advance and Prospect of Positron Emission Tomography in Alzheimer’s disease research

Yulin Wang
Wanchen Liao
Ping Luan
Reviews21 Jun 2025
Molecular Psychiatry

P: 1-11
Stacking selected polarization switching and phase transition in vdW ferroelectric α-In₂Se₃ junction devices

The lack of information on the ferroelectric ___domain walls motion characteristics in α-In₂Se₃ hampers the understanding of the ferroelectric semiconductor junction device mechanism. Here, the authors report that the stacking order of van der Waals α-In₂Se₃ determines its ferroelectric ___domain wall type and phase transition pathway.

Yuyang Wu
Tianjiao Zhang
Renchao Che
ResearchOpen Access02 Dec 2024
Nature Communications

Volume: 15, P: 1-10
A dataset of multi-level street-block divisions of 985 cities worldwide

Jintong Tang
Liyan Xu
Yu Liu
ResearchOpen Access19 Mar 2025
Scientific Data

Volume: 12, P: 1-15
Antifreeze protein from Ammopiptanthus nanus functions in temperature-stress through ___domain A

HaoQiang Yu
HongYing Zheng
FengLing Fu
ResearchOpen Access19 Apr 2021
Scientific Reports

Volume: 11, P: 1-10
Predictive and clinicopathological importance of HMGB2 in various carcinomas: a meta and bioinformatic approach

Yinan Zhu
Siyu He
Xuyong Lin
ResearchOpen Access31 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
Exon-intron circular RNAs regulate transcription in the nucleus

The identification of a new subclass of circular RNAs that are predominantly nuclear and promote transcription of their parental genes reveals a new regulatory function for these noncoding RNAs.

Zhaoyong Li
Chuan Huang
Ge Shan
Research09 Feb 2015
Nature Structural & Molecular Biology

Volume: 22, P: 256-264
A nomogram for predicting the risk of cancer-related cognitive impairment in breast cancer patients based on a scientific symptom model

Zhongtao Zhou
Jiajia Ren
Jing Zhang
ResearchOpen Access24 Jun 2024
Scientific Reports

Volume: 14, P: 1-14

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Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro

De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS

Correction: Corrigendum: Exon-intron circular RNAs regulate transcription in the nucleus

Advance and Prospect of Positron Emission Tomography in Alzheimer’s disease research

Stacking selected polarization switching and phase transition in vdW ferroelectric α-In₂Se₃ junction devices

A dataset of multi-level street-block divisions of 985 cities worldwide

Antifreeze protein from Ammopiptanthus nanus functions in temperature-stress through ___domain A

Predictive and clinicopathological importance of HMGB2 in various carcinomas: a meta and bioinformatic approach

Exon-intron circular RNAs regulate transcription in the nucleus

A nomogram for predicting the risk of cancer-related cognitive impairment in breast cancer patients based on a scientific symptom model

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