Nature Search

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

Timothy Vyse, Yong Cui, Wanling Yang and colleagues report a meta-analysis of genome-wide association studies for systemic lupus erythematosus (SLE) including European and Chinese individuals. They identify ten new loci associated with SLE and find evidence for increased genetic risk of disease among individuals of non-European ancestry.

David L Morris
Yujun Sheng
Timothy J Vyse
Research11 Jul 2016
Nature Genetics

Volume: 48, P: 940-946
Evidence for genetic association of TBX21 and IFNG with systemic lupus erythematosus in a Chinese Han population

Rui-Xue Leng
Hai-Feng Pan
Dong-Qing Ye
ResearchOpen Access26 Feb 2016
Scientific Reports

Volume: 6, P: 1-5
ECT2⁺ cell group acts as cancer stem cell in malignant pleomorphic adenoma

Wanling Chen
Yang Wang
Jiang Li
ResearchOpen Access17 Jun 2025
npj Precision Oncology

Volume: 9, P: 1-12
Discovery of metabolic biomarkers for distinguishing LAA and SVO subtypes of acute ischemic stroke

Yan Yu
Peijia Liu
Peifang Liu
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Investigating the PI3K/AKT/mTOR axis in Buzhong Yiqi Decoction’s anti-colorectal cancer activity

Song Qiao
Xiaolong Li
Wanling Lu
ResearchOpen Access10 Mar 2025
Scientific Reports

Volume: 15, P: 1-14
Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

The presentation of systemic lupus erythematosus has been known to differ by ancestry, but the underlying genetic factors remain unclear. Here, the authors report ancestry-specific susceptibility loci and better risk prediction when using data from matched ancestral groups.

Yong-Fei Wang
Yan Zhang
Wanling Yang
ResearchOpen Access03 Feb 2021
Nature Communications

Volume: 12, P: 1-13
Long-term variability of extreme precipitation with WRF model at a complex terrain River Basin

Yinchi Zhang
Chao Deng
Lu Gao
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-16
A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging

The second messenger cAMP modulates a wide range of important biological processes. Here, the authors developed a fluorescent indicator termed G-Flamp1, which can accurately report levels of cAMP in living cells.

Liang Wang
Chunling Wu
Jun Chu
ResearchOpen Access12 Sept 2022
Nature Communications

Volume: 13, P: 1-16
Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway

Different types of mesenchymal progenitors participate in ectopic bone formation. Here, the authors show Col2⁺ lineage cells adopt a lymphatic endothelium cell fate, which regulates local inflammatory microenvironment after trauma, thus influencing heterotopic ossification (HO) development via a FGFR3-BMPR1a pathway.

Dali Zhang
Junlan Huang
Yangli Xie
ResearchOpen Access19 Jul 2021
Nature Communications

Volume: 12, P: 1-16
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

Remi Stevelink
Ciarán Campbell
Quratulain Zulfiqar Ali
ResearchOpen Access31 Aug 2023
Nature Genetics

Volume: 55, P: 1471-1482
Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery

The functional effects of genetic loci associated with autoimmune disease are not well understood. By dissecting an autoimmune disease genetic locus, the authors define an immune cell-type-specific enhancer and the molecular mechanisms underlying the dysregulation of IRF8 expression by lupus risk variants.

Tian Zhou
Xinyi Zhu
Nan Shen
ResearchOpen Access06 Apr 2022
Nature Communications

Volume: 13, P: 1-16
Growth hormone peak modifies the effect of BMI on increased systolic blood pressure in children with short stature

Yanying Li
Yanhong Zhang
Bo Ban
ResearchOpen Access27 May 2019
Scientific Reports

Volume: 9, P: 1-7
Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies

Wanling Yang
Zhanyong Wang
Yu Lung Lau
Research25 Jun 2008
European Journal of Human Genetics

Volume: 16, P: 1535-1543
Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy

Xu-Jie Zhou
Swapan K Nath
Hong Zhang
ResearchOpen Access02 Nov 2016
Scientific Reports

Volume: 6, P: 1-7
PtdIns(4,5)P₂ stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

Mass spectrometry-based assays are used to reveal specificity and structural determinants of lipid binding to class A G-protein-coupled receptors, and the effects of specific lipids on receptor coupling to G proteins.

Hsin-Yung Yen
Kin Kuan Hoi
Carol V. Robinson
Research11 Jul 2018
Nature

Volume: 559, P: 423-427
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Epilepsies are common brain disorders and are classified based on clinical phenotyping, imaging and genetics. Here, the authors perform genome-wide association studies for 3 broad and 7 subtypes of epilepsy and identify 16 loci - 11 novel - that are further annotated by eQTL and partitioned heritability analyses.

Bassel Abou-Khalil
Pauls Auce
Fritz Zimprich
ResearchOpen Access10 Dec 2018
Nature Communications

Volume: 9, P: 1-15
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

The Hong Kong–Shanghai, Korean, Taiwan, US and International Kawasaki Disease Genetics Consortia report a genome-wide association study in Kawasaki disease. They identify a novel locus in the FCGR2A gene that confers elevated risk of disease.

Chiea Chuen Khor
Sonia Davila
Stephen Harrap
Research13 Nov 2011
Nature Genetics

Volume: 43, P: 1241-1246
Integrated genomic and transcriptomic analysis reveals the activation of PI3K signaling pathway in HPV-independent cervical cancers

Yi Wang
Misi He
Huijuan Yang
ResearchOpen Access22 Jan 2024
British Journal of Cancer

Volume: 130, P: 987-1000
Actionable secondary findings in 1116 Hong Kong Chinese based on exome sequencing data

Mullin Ho Chung Yu
Christopher Chun Yu Mak
Brian Hon Yin Chung
Research22 Nov 2020
Journal of Human Genetics

Volume: 66, P: 637-641
Analysis of leaf morphology, secondary metabolites and proteins related to the resistance to Tetranychus cinnabarinus in cassava (Manihot esculenta Crantz)

Yanni Yang
Xinglu Luo
Xiaolu Pan
ResearchOpen Access26 Aug 2020
Scientific Reports

Volume: 10, P: 1-13
Emergence of quantum confinement in topological kagome superconductor CsV₃Sb₅

Kagome superconductors provide a platform to explore intertwined symmetry-breaking orders, but controversies remain despite intensive experimental and theoretical efforts. Here, a combined density functional theory and angle-resolved photoemission spectroscopy study reveals quantum confinement phenomena on the surface of CsV₃Sb₅, reconciling conflicting observations of time-reversal symmetry breaking between bulk- and surface-sensitive probes.

Yongqing Cai
Yuan Wang
Chaoyu Chen
ResearchOpen Access13 Mar 2024
Communications Materials

Volume: 5, P: 1-7
GmBTB/POZ promotes the ubiquitination and degradation of LHP1 to regulate the response of soybean to Phytophthora sojae

Zhang et al characterise the mechanism by which GmBTB/POZ enhances resistance to P. sojae in soybean. They show that GmBTB/POZ directly associates with the heterochromatin protein GmLHP1 and mediates its degradation to regulate the salicylic acid signaling pathway, providing insights into the defence against a common soybean disease.

Chuanzhong Zhang
Qun Cheng
Pengfei Xu
ResearchOpen Access19 Mar 2021
Communications Biology

Volume: 4, P: 1-15
Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1

Maoguang Xue
Fei Cong
Wanzhong Ge
ResearchOpen Access05 Aug 2023
Cell Death Discovery

Volume: 9, P: 1-14
Comprehensive analysis of recessive carrier status using exome and genome sequencing data in 1543 Southern Chinese

Jeffrey Fong Ting Chau
Mullin Ho Chung Yu
Clara Sze Man Tang
ResearchOpen Access21 Mar 2022
npj Genomic Medicine

Volume: 7, P: 1-9
Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Zuqiang Wang
Hangang Chen
Yangli Xie
ResearchOpen Access05 Jan 2022
Bone Research

Volume: 10, P: 1-16
Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey

Christopher CY Mak
Gordon KC Leung
Brian HY Chung
ResearchOpen Access06 Aug 2018
npj Genomic Medicine

Volume: 3, P: 1-10
Varied Probability of Staying Collapsed/Extended at the Conformational Equilibrium of Monomeric Aβ₄₀ and Aβ₄₂

Wanling Song
Yuanyuan Wang
Yechun Xu
ResearchOpen Access05 Jun 2015
Scientific Reports

Volume: 5, P: 1-13
Notch signaling pathway: architecture, disease, and therapeutics

Binghan Zhou
Wanling Lin
Qian Chu
ReviewsOpen Access24 Mar 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-33

Search

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

Evidence for genetic association of TBX21 and IFNG with systemic lupus erythematosus in a Chinese Han population

ECT2⁺ cell group acts as cancer stem cell in malignant pleomorphic adenoma

Discovery of metabolic biomarkers for distinguishing LAA and SVO subtypes of acute ischemic stroke

Investigating the PI3K/AKT/mTOR axis in Buzhong Yiqi Decoction’s anti-colorectal cancer activity

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

Long-term variability of extreme precipitation with WRF model at a complex terrain River Basin

A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging

Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery

Growth hormone peak modifies the effect of BMI on increased systolic blood pressure in children with short stature

Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies

Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy

PtdIns(4,5)P₂ stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

Integrated genomic and transcriptomic analysis reveals the activation of PI3K signaling pathway in HPV-independent cervical cancers

Actionable secondary findings in 1116 Hong Kong Chinese based on exome sequencing data

Analysis of leaf morphology, secondary metabolites and proteins related to the resistance to Tetranychus cinnabarinus in cassava (Manihot esculenta Crantz)

Emergence of quantum confinement in topological kagome superconductor CsV₃Sb₅

GmBTB/POZ promotes the ubiquitination and degradation of LHP1 to regulate the response of soybean to Phytophthora sojae

Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1

Comprehensive analysis of recessive carrier status using exome and genome sequencing data in 1543 Southern Chinese

Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey

Varied Probability of Staying Collapsed/Extended at the Conformational Equilibrium of Monomeric Aβ₄₀ and Aβ₄₂

Notch signaling pathway: architecture, disease, and therapeutics

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