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An almost ideal quantum anomalous Hall state is observed in (Bi,Sb)Te films doped with vanadium. This state is reached without the application of a polarizing magnetic film, making these materials interesting for low-power electronic applications.

Hydrogen produced directly from neutral seawater is promising but challenging due to seawater’s complex composition. Here, the authors report a Na⁺-conducted pH-asymmetric electrolyzer that can directly split seawater into hydrogen with low electricity cost and nearly zero chloride interference.

Lin et al. show that MCM8 protects vascular health by mediating nitric-oxide-dependent mitophagy. The common East-Asian MCM8-P276 variant is ineffective in mitophagy, which potentiates cGAS-STING and type I interferon signaling in a mouse model of Kawasaki disease.

A complete telomere-to-telomere genome assembly of the maize Mo17 inbred line uncovers structural features of the highly complex maize genome.

Echovirus 30 (E30) belongs to the Enterovirus-B group and causes aseptic meningitis in humans. Here, the authors present the cryo-EM structures of the E30 E-particle, A-particle and the mature virion, as well as structures of E30 in complex with its receptor FcRn and CD55, and furthermore they describe a structure-based algorithm that allows the prediction of EV receptor usage.

Green perovskite light-emitting diodes with external quantum efficiencies of up to 19.1% at high brightness can be created by depositing an ultrathin layer of strongly polar lithium fluoride between the perovskite and hole-transport layers.

Male and female B cells show differing abilities to localize and contribute to germinal centres, in a way that depends on the G-protein-coupled guidance receptor GPR174 and its chemokine ligand CCL21.

A reproductive barrier between japonica and indica rice subspecies hinders hybrid breeding. Here, the authors reveal that structural and copy number variations of a pollen-essential gene, which encodes a DUF1618-___domain protein, result in allelic suppression and subsequently cause hybrid male sterility.

A high-quality draft genome assembly of Musa balbisiana (the banana B-genome) is reported. Comparative genomic and gene functional analyses provide insights into the subgenome evolution and functional divergence between the A- and B-subgenomes.

Twisted bilayers of 2D semiconductors are being intensively investigated due to their emergent physical properties, but their controlled bottom-up synthesis remains challenging. Here, the authors report a confined-space chemical vapour deposition strategy to synthesize MoS₂ bilayers with twist angles ranging from 0° to 120°.

Degradable polymeric porous microcapsules loaded with exosomes from mesenchymal stem cells or regulatory T cells led to the restoration of retinal thickness in mice with retinal ischaemia-reperfusion injury and to reductions in inflammatory cells in monkeys with mycobacterial uveitis.

Trivalent arsenic (As^III) is a clinically approved treatment agent for patients with promyelocytic leukaemia, but cannot be used for other types of leukaemia due to its toxicity. Here the authors show that different patient-derived leukaemia cells express CD71 and design a ferritin-based nanoparticle for specific delivery of As^III to these cells, demonstrating substantially improved efficacy towards different leukaemia types in animal models, with reduced side effects.

A consortium reports the tripling of the number of genetic markers in Phase II of the International HapMap Project. This map of human genetic variation will continue to revolutionize discovery of susceptibility loci in common genetic diseases, and study of genes under selection in humans.

Magnetic topological materials have a variety of interesting properties, but very few material realizations exist. Here, the authors report a topological nodal-line semimetal and a topological massive Dirac metal phase in EuAs₃ and demonstrate a magnetism-driven transition between these phases.

A protocol in which monomers are pre-organized using a reversible and removable urea linkage enables the production of covalent organic frameworks with higher crystallinity and porosity than those produced using standard approaches with randomly aligned monomers.

Using single-cell transcriptomics, the authors generate a brain cell atlas for the pharaoh ant including individuals of different sexes and castes and show changes in cell composition underlying division of labour and reproductive specialization.

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

A three-phase system that is composed of a ferroelectric Na_0.5Bi_0.5TiO₃ matrix in which ferrimagnetic NiFe₂O₄ nanocolumns coated with antiferromagnetic p-type NiO are embedded exhibits self-biased magnetoelectric switching at room temperature.

Obesity is often accompanied by chronic inflammation. Li and colleagues show that, in mice fed high-fat diets, IL-1 signaling in adipocytes induces an unconventional IRAK2 translocation to mitochondria and suppresses respiratory super-complex formation to alter mitochondrial function, and exacerbates obesity.

Mutations in the gene encoding PC1 cause ADPKD, a common genetic renal disease. Here, the authors show that expression of the C-terminal 200 amino acids of the large PC1 protein in mouse models of ADPKD suppresses cystic disease through an interaction with the mitochondrial enzyme NNT.

Cas13d is a class 2 type VI-D CRISPR-Cas RNA-guided RNase. Here the authors present the high-resolution crystal structure of the uncultured Ruminococcus sp. Cas13d (UrCas13d)-crRNA complex and by combining structural, mutational and biochemical studies provide mechanistic insights into the CRISPR-Cas13d system.

By entangling the phase and spin of light, a synthetic metasurface is shown to be able to coherently manipulate the valley-exciton-locked chiral emission in monolayer tungsten disulfide at room temperature. The findings will be of benefit to advanced room-temperature and free-space nonlinear, quantum and valleytronic nanodevices.

The neural circuits through which the substantia nigra pars reticulata (SNr) exerts its role in epilepsy control are not known. Here the authors reveal that a long-range SNr-parafascicular nucleus disinhibitory circuit participates in regulating seizures in temporal lobe epilepsy and inhibition of this circuit can alleviate severity of epileptic seizures.

Improved compressive elasticity was lately demonstrated for carbon aerogels but the problem of reversible stretchability remained a challenge. Here the authors use a hierarchical structure design and synergistic effects between carbon nanotubes and graphene to achieve high stretchability in carbon aerogels.

Efficient electron-hole separation and carrier utilization are key factors in photosynthetic systems. Here, the authors achieve efficient charge separation following a photogenerated hole-transfer band-trap pathway in the ternary composite Pt@NH₂-UiO-66/CdS, resulting in photocatalytic hydrogen evolution with good stability and a quantum efficiency of 40.3% at 400 nm irradiation.

The CWO protein is part of a feedback loop that contributes to the high-amplitude circadian oscillation in Drosophila. Here, the authors identify microRNA let-7 as a regulator of circadian rhythm via repression of cwo, and show the circadian expression of let-7 is regulated by ecdysteroid and its receptor.

Electronic many-body effects are used to control the electron effective mass, and thus the plasma energy and electrical conductivity, of thin films of the correlated metals SrVO₃ and CaVO₃, making them good candidates as transparent conductors.

The establishment of a pre-metastatic niche is a key step preceding metastasis formation. Here the authors show that tumor-intrinsic Lin28B, a RNA-binding protein, has an essential role in the formation of an immune-suppressive pre-metastatic niche, promoting lung metastasis of breast cancer.

Inhibition of intestinal MYC is shown to have beneficial metabolic effects by promoting GLP-1 secretion and reducing ceramide production.

The shape of plant organs shows low variability. Sepals of the same age look the same. Here the authors identify one transcription factor (DRMY1) crucial for sepal size reproducibility, and its effect on initiation timing and growth of the organ.

Intravitreally injected exosomes derived from regulatory T cells and conjugated with an antibody for vascular endothelial growth factor via a cleavable linker markedly suppress ocular neovascularization in mice and non-human primates.

Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.