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Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

The methyltransferase OsPRMT6b is found to act as an ABA responsive factor to finely turn down ABA signaling via methylation of ABA receptor, thus facilitating growth recovery as high-temperature stress subsides.

Preclinical studies have shown synergy in the combination of tifcemalimab (anti-BTLA antibody) with toripalimab (anti-PD-1 antibody) in lymphoma. Here, the authors report a clinical trial investigating tifcemalimab alone and in combination with toripalimab in patients with relapsed or refractory lymphoma.

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

Post-translational modification of the human glycine receptors underly inflammatory pain. Here the authors discover how phosphorylation in an unstructured internal loop changes receptor structure and function, which provides new perspective for pain control development.

Compounds containing copper have long been targeted in the search for high-temperature superconductivity, but experiments performed at extreme pressures suggest that nickel-based materials might also be candidates.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

The various binding models of the GH57 family amylopullulanase with its substrate reveal a dual catalytic mechanism for glycosidic bond cleavage and a broad substrate recognition capability.

Catalytic asymmetric fluorination remains elusive, especially the longstanding stereochemical challenges which exist in BF₃Et₂O-based fluorinations. Here the authors show a catalytic asymmetric nucleophilic fluorination using BF₃·Et₂O as the fluorine reagent in the presence of chiral iodine catalyst.

A combination of Floquet engineering and higher-order topological insulators has been lately only theoretically proposed. Here the authors experimentally realize an acoustic waveguides array to demonstrate a Floquet higherorder topological insulator extending its band topology from first order to higher order.

Disturbed lipid metabolism is a feature of diabetic kidney disease (DKD). Here the authors report that ceramide synthase 6 (CerS6) in podocytes contributes to the pathogenesis of diabetic kidney disease (DKD) in male mice by inducing mitochondrial DNA leakage, activating the cGAS-STING pathway and promoting inflammation.

The molecular mechanisms underlying the function of different cellular states in glioblastoma stem cells (GSCs) remain poorly understood. Here, the authors perform integrated single cell and bulk analysis of GSCs and identify potential therapeutic targets.

Metallic molybdenum disulfide is a metastable phase of the material. Here, the authors synthesize two-dimensional metallic molybdenum disulfide nanosheets, stabilized by adsorbed aqueous monolayers, and evaluate their catalytic hydrogen evolution activity.

The irradiation of crystalline materials is known to create various types of lattice defects, which can degrade mechanical performance. Here, Xu et al. observe the in-situnucleation and growth of atomic-scale voids in magnesium during electron irradiation.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Eye tracking techniques enable high-efficient, natural, and effortless human-machine interaction. Here, Zhu et al. proposed a contact lens to track eye movement for wireless eye-machine interaction

Here the authors propose a self-homodyne fronthaul architecture, utilizing DA-RoF super channels and multicore fiber, paving the way for the Pb/s era in fronthaul transmission, enabling ultra-highspeed Internet access. The remarkable data speeds reaching 0.879 Pb/s and the 256-QAM format make it possible for 150,000 5G channels to be accessed simultaneously.

A large range of inert and non-defective sites in catalysts is a primary factor impeding catalyst activity in acidic CO₂ electroreduction. Here, the authors achieve high HCOOH selectivity and activity in acidic electrolyte by introducing tensile strain to activate inert sites.

Reaching the depths of the respiratory tract is hard even with vapor-based drug delivery. Here, the authors devise inhalable biohybrid microrobots that, thanks to their motility, reach deeper regions of the lungs.

Echovirus 30 (E30) belongs to the Enterovirus-B group and causes aseptic meningitis in humans. Here, the authors present the cryo-EM structures of the E30 E-particle, A-particle and the mature virion, as well as structures of E30 in complex with its receptor FcRn and CD55, and furthermore they describe a structure-based algorithm that allows the prediction of EV receptor usage.

An efficient molecular nanojunction photocatalyst for hydrogen evolution is identified from a combinatorial molecular library, assisted by a materials acceleration platform, which is then scaled-up to the litre scale using flow synthesis.

Renal tubular atrophy is a hallmark of chronic kidney disease. The study by Zhu et al. reveals the protective role of tubular polynucleotide phosphorylase (PNPT1) against renal atrophy by blocking the leakage of mitochondrial dsRNAs into cytoplasm where they activate the PKReIF2α axis and terminate translation.

Neuroendocrine prostate cancer (NEPC) is an aggressive subtype with limited effective therapeutic options. Here, the authors identify the RNA-binding protein ELAVL3 as a driver of differentiation into NEPC via a positive feedback loop with MYCN and demonstrate the use of the repurposed drug pyrvinium pamoate to target this axis using preclinical models of NEPC.

Hepatocellular carcinomas (HCC) present spatial intratumour heterogeneity (sITH). Here, the authors perform a genomic and phylogenetic analysis of spatially-sampled HCC tumour sections, observe block-shaped sITH, and find ongoing natural selection where ancestral and derived clones spatially compete in the same tumor.

Cui, Guo, Liu et al. identify a bacterial species, Peptostreptococcus anaerobius, in the gut that produces a tryptophan metabolite and engages intracellular pathways to modulate ferroptosis-suppressor protein 1 activity, thereby suppressing ferroptosis and promoting colorectal cancer development.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

A cereal-specific transcription factor, ZmICE1a, positively regulates storage in the central part of the endosperm while negatively regulating defence in its peripheral region, revealing the molecular mechanism underlying the antagonism between resistance and yield, which is crucial for cereal crop improvement.

A high-κ dielectric ceramic, magnesium niobate, can be epitaxially grown on a mica substrate and then transferred to form the gate dielectric in molybdenum disulfide transistors, providing van der Waals interfaces and high robustness to temperature and voltage.

A protocol in which monomers are pre-organized using a reversible and removable urea linkage enables the production of covalent organic frameworks with higher crystallinity and porosity than those produced using standard approaches with randomly aligned monomers.

In this work, the authors present an ice-templating strategy to produce large-scale isotropic nanofiber aerogels using a unique process of freezing the material on a rotating cryogenic drum surface, crushing it, and then re-casting the nanofiber slurry enabling high-throughput and design flexibility.

The use of clone combs provides very high-capacity radio-over-fibre data transmission with high-order modulation formats.

Inspired by the idea of mimicking virus entry to host cells and macrophage-mediated virus clearance, the authors developed a lysosomal “TRAP”, which could efficiently capture, internalize, and degrade viruses and variants.

A multimodal model for the stratification of breast cancer risk based on clinical metadata, mammography and trimodal ultrasound images performed as well as or better than radiologists at tumour classification and at differential diagnosis.

Transition metal oxides are a promising class of materials to engineer multiferroic properties for next-generation spintronic devices. Here, the authors demonstrate an emergent and robust ferromagnetic-insulating state in ferroelastic LaCoO₃ epitaxial films by strain-defect-microstructure manipulated electronic and magnetic states.

Insect salivary protein (BISP) targets OsRLCK185 to suppress defence in susceptible plants, whereas in resistant plants BISP binds BPH14 to activate host plant resistance. To restore cellular homeostasis, the resistance mechanism is fine-tuned by selective autophagy.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

Manufacturing of perovskite solar cells under ambient conditions is desirable. Meng et al. show that dimethylammonium formate suppresses halide oxidation and deprotonation of organic cations, enabling air-processed inverted solar cells with 24.7% efficiency.

Nanosizing covalent organic frameworks using surfactants provides greatly improved water dispersibility and light-harvesting properties, leading to dramatically enhanced photocatalytic hydrogen production performance. Here the authors observe a reverse concentration-dependent photocatalytic phenomeno, whereby a higher photocatalytic activity is found at a lower catalyst concentration.