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Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

The kinetic pathways driving morphological changes in core-shell metallic nanowires are crucial for their functional properties. Here authors reveal a three-step deposition process, and influence nanoparticle size and surface roughness.

Using two cohorts, Liu, Ge, Xiao, Lu and colleagues perform plasma metabolomics and lipidomics, linking reduced sarcosine to sarcopenia diagnosis. In mice, they demonstrate that sarcosine enhances muscle repair, boosts adipose thermogenesis and preserves muscle mass via macrophage modulation.

Although aryl triflates are essential building blocks in organic synthesis, the applications as aryl radical precursors are limited. Here, the authors report an organomediated electrochemical strategy for the generation of aryl radicals from aryl triflates, providing a method for the synthesis of aryl sulfonyl fluorides from feedstock phenol derivatives under very mild conditions.

Effectiveness of the hepatitis E vaccine HEV 239 amongst high-risk groups isn’t well studied. Here, Zhuang et al. analyse a decade of surveillance data (2007–2017) from Dongtai, China, and estimate HEV 239 effectiveness of 72% amongst hepatitis B virus infected people.

Common aromatic rings, such as anilines, arylboronic acids and aryl halides, can be opened up and converted to alkenyl nitriles through carbon–carbon bond cleavage using a copper catalyst.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

The authors demonstrate a chemopiezoelectric effect in which the displacive migration of oxygen vacancies driven by an electric field induces a large strain in the surface layer of thin (K,Na)NbO₃ ceramics. They achieve an electrostrain of 1.9% under a field of −3 kV mm⁻¹, with thermal stability up to 200 °C.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Whole-genome resequencing and association analyses in 424 soybean accessions identify two homeologous genes that contributed to flowering time adaptation during soybean domestication.

Cell softness protects cytotoxic T lymphocytes (CTL) from autolysis by own soluble factors such as perforin secreted for killing target cells. Here the authors show that softness can be induced by YAP activation, and that T leukemic cells are more sensitive to YAP inhibition than CTLs, thereby hinting YAP inhibitors as a potential therapy for T leukemia.

Moderate disorder can induce topologically nontrivial phases. Liu et al. report the experimental observations of the competition and interplay between Thouless pumping and disorder on a 41-qubit superconducting quantum processor.

Multiomics joint analyses based on a structural variant (SV) map from 16 genome assemblies and 2,105 resequenced accession genomes shed light on the regulatory effect of SVs on gene expression and trait variation in Brassica napus.

B cell activation and differentiation entails metabolic remodelling, involving differential utilisation of monocarboxylates such as L-lactate and pyruvate. Here authors show by B-cell-specific genomic deletion of monocarboxylate transporter 1 (MCT1) that the consequential scarcity of pyruvate results in decreased acetylation of Histone H3 at K27, leading to decreased AID transcription and deficient class switching to IgG.

CRISPR-Cas9 genome editing systems have great potential in cancer therapy. Here the authors report a gene-editing delivery system using functionalized nanovesicles derived from E. coli protoplasts to encapsulate Cas9-sgRNA ribonucleoprotein for the selective targeting of Pik3cg in tumor associated macrophages.

The authors enhance energy storage performance in tetragonal tungsten bronze structure ferroelectrics using a multiscale regulation strategy. By adjusting the composition and sintering process of BaSrTiNb_2-xTa_xO₉ ceramics, they introduce grain refinement and perovskite second-phase precipitation.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Quantum simulations of topological matter with superconducting qubits have been attracting attention recently. Xiang et al. realize 2D and bilayer Chern insulators with synthetic dimensions on a programmable 30-qubit-ladder superconducting processor, showing bulk-boundary correspondence.

Sugar metabolic reprogramming is a hallmark of various diseases including cancer. Here, the authors report a thermal proteome profiling (TPP)-based strategy to profile the FBP interactome and describe a chemical signaling role for FBP, contributing to an intrapathway feedback for glycolysis and cell proliferation.

A precise adenine base editor variant, ABE9, was developed to generate single adenine transition at pathogenic homopolymeric adenine sites with minimal DNA/RNA off-target effects, suggesting promising potential for gene therapeutics.

Unbiasedly benchmarking SRT computational methods remains a pressing challenge. Here, authors develop scCube, a simulation framework enabling scalable, reproducible, and unbiased generation of simulated SRT data, allowing researchers to benchmark and evaluate different methods.

Chromosome-scale genome assemblies of triploid Cavendish and Gros Michel reveal the banana cultivars’ origins, disease resistance and fruit ripening mechanism.

Quantum devices offer the potential to simulate quantum phenomena, which are otherwise computationally intractable. Here, Shi, Sun, Wang and coauthors use a superconducting quantum simulator to study spin-transport at infinite temperature.

Technical advancements have significantly improved early diagnosis of cervical cancer, but accurate diagnosis is still difficult due to various practical factors. Here, the authors develop an artificial intelligence assistive diagnostic solution to improve cervical liquid-based thin-layer cell smear diagnosis according to clinical TBS criteria in a large multicenter study.

The PI3K/AKT signalling pathway regulates cancer metabolism. Here, the authors show a reciprocal positive feedback crosstalk between the PI3K/AKT and pentose phosphate pathway which promotes tumourigenesis.

Splice isoform switching regulated by the heterogeneous nuclear ribonucleoprotein M (hnRNPM) induces EMT and metastasis. Here, the authors report that AKAP8 is a metastasis suppressor that inhibits the splicing activity of hnRNPM and antagonizes genome-wide EMT-associated alternative splicing to maintain epithelial cell state.

Activated hepatic stellate cells are the principal contributors to liver fibrosis by secreting a variety of pro-fibrogenic cytokines . Here Zhang et al. demonstrate that a liver-enriched lncRNA, lnc-LFAR1, promotes liver fibrosis and HSC activation by activating TGFβ and Notch signaling.

Kynurenine, a tryptophan metabolite, is increased in the circulating plasma of obese individuals, but the source has been unclear. Here, the authors show in mice that mature adipocytes produce kynurenine, with vitamin B6 administration preventing accumulation and protecting against high-fat diet.

One key challenge in water science is to create a universal model that can predict the arrangement of water/solid interfaces. Here, the authors use STM and noncontact-AFM to discover common water clusters during the initial growth on hydrophilic and hydrophobic close-packed metal surfaces.

How soybean, a temperate origin crop, adapted to a tropical environment remains unclear. Here, the authors report Tof16, an ortholog of LHY, and the previously identified J locus, control soybean yield under short-day condition and loss of function of these two genes contributes to the adaptation to tropics.

Investigation of a chromium-based metal–organic framework shows that the ___location of added TiO₂ inside specific mesopores strongly affects the ability of the material to catalyse photoreduction of CO₂.

Long-term stability of organic solar cells is critical to promote practical applications. Here, the authors utilize iridium/iridium oxide nanoparticles as the electron-transporting material and realize enhanced device stabilities under thermal aging with T70 of over 10000 h.

Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.

Cell-cell communication is a vital feature involving numerous biological processes. Here, the authors develop SpaTalk, a cell-cell communication inference method using knowledge graph for spatially resolved transcriptomic data, providing valuable insights into spatial intercellular tissue dynamics.

TAAR1 has a rigid consensus binding motif that binds to endogenous trace amine stimuli as well as two extended binding pockets that accommodate diverse chemotypes.

The formation of secondary organic aerosol in Chinese megacities is dominated by the condensation of anthropogenic organic vapours, according to measurements across three urbanized regions.

Tumour cells can communicate with cells from distant organs through extracellular vesicles. Here the authors show that breast cancer cells derived exosomal miR-204-5p induce leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia.

The early identification of metabolic disorders could improve or prevent overt disease. Here the authors show that the circulating concentration of hyocholic acid (HCA) species is decreased in the context of obesity and diabetes and increased after gastric bypass surgery in humans, and further that serum HCA species are predictive of metabolic outcomes in healthy individuals.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Multiple morphological abnormalities of the sperm flagella (MMAF) is a cause of male infertility. Here the authors identify homozygous nonsense mutations of the glutamine rich 2 (QRICH2) gene in two MMAF patients from 2 consanguineous families and show using QRICH2 knockout mice that the protein is required for sperm flagellar formation and motility.