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Showing 51–100 of 123 results

Advanced filters: Author: Xiaojun Han Clear advanced filters

Artificial intelligence in the COVID-19 pandemic: balancing benefits and ethical challenges in China’s response

Xiaojun Ding
Bingxing Shang
Feng Yu
ResearchOpen Access23 Feb 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-19
Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

Nasopharyngeal carcinoma is a diverse cancer characterised by a heterogeneous microenvironment. Here, the authors use single cell sequencing to analyse the tumour microenvironment in 10 nasopharyngeal carcinoma tumours and identify different cell types including immune-suppressive T regulatory, tolerogenic dendritic, and exhausted CD8 T cells.

Yang Liu
Shuai He
Jin-Xin Bei
ResearchOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1-18
A donor PD-1⁺CD8⁺ T_SCM-like regulatory subset mobilized by G-CSF alleviates recipient acute graft-versus-host-disease

Dan Liu
Xue Wang
Liming Lu
ResearchOpen Access02 Apr 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-19
Selective hydrogenation of 5-(hydroxymethyl)furfural to 5-methylfurfural over single atomic metals anchored on Nb₂O₅

Selective hydrogenation of 5-(hydroxymethyl)furfural (HMF) to 5-Methylfurfural using H2 as reductant is very attractive, but remains challenging. Here, the authors report that isolated single atomic catalysts can catalyze the reaction efficiently with selectivity >99% at complete conversion of HMF.

Shaopeng Li
Minghua Dong
Buxing Han
ResearchOpen Access26 Jan 2021
Nature Communications

Volume: 12, P: 1-9
Locating potentially lethal genes using the abnormal distributions of genotypes

Xiaojun Ding
Xiaoshu Zhu
ResearchOpen Access22 Jul 2019
Scientific Reports

Volume: 9, P: 1-7
Eltrombopag is an effective and safe therapy for refractory thrombocytopenia after haploidentical hematopoietic stem cell transplantation

Haixia Fu
Xiaohui Zhang
Lanping Xu
Research21 Jan 2019
Bone Marrow Transplantation

Volume: 54, P: 1310-1318
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

Cancer subtypes may have distinct metabolic vulnerabilities that can be exploited for therapeutic interventions. Here, the authors show that in lung cancer, genetic activation of distinct oncogenic receptor tyrosine kinases results in unique metabolic liabilities and, in particular, EGFR aberrant cancers rely on the serine biosynthetic pathway while FGFR aberrant cancers rely on glycolysis.

Nan Jin
Aiwei Bi
Min Huang
ResearchOpen Access20 Jun 2019
Nature Communications

Volume: 10, P: 1-15
CD4⁺CD25⁺ T Cells in primary malignant hypertension related kidney injury

Hongdong Huang
Yang Luo
Xiaoqun Dong
ResearchOpen Access09 Jun 2016
Scientific Reports

Volume: 6, P: 1-9
Pathway Analyses Identify Novel Variants in the WNT Signaling Pathway Associated with Tuberculosis in Chinese Population

Xuejiao Hu
Juan Zhou
Binwu Ying
ResearchOpen Access23 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
Myeloid PTEN loss affects the therapeutic response by promoting stress granule assembly and impairing phagocytosis by macrophages in breast cancer

Yan Li
Chao Xu
Yueyin Pan
ResearchOpen Access30 Jul 2024
Cell Death Discovery

Volume: 10, P: 1-14
A vacuum ultraviolet laser with a submicrometer spot for spatially resolved photoemission spectroscopy

Yuanhao Mao
Dong Zhao
Yulin Chen
ResearchOpen Access21 Jan 2021
Light: Science & Applications

Volume: 10, P: 1-8
A Two-Photon Fluorescent Probe for Lysosomal Thiols in Live Cells and Tissues

Jiangli Fan
Zhichao Han
Xiaojun Peng
ResearchOpen Access22 Jan 2016
Scientific Reports

Volume: 6, P: 1-8
Retinal synaptic regeneration via microfluidic guiding channels

Ping-Jung Su
Zongbin Liu
Lidong Qin
ResearchOpen Access28 Aug 2015
Scientific Reports

Volume: 5, P: 1-7
The abscisic acid signaling negative regulator OsPP2C68 confers drought and salinity tolerance to rice

Beilei Wang
Yuping Luo
Xiaojun Dai
ResearchOpen Access25 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

New noncoding RNAs can be discovered by assembling transcripts from RNA-Seq data. Prensner et al. apply this approach across >100 prostate cancer samples to find noncoding RNAs that distinguish localized tumors from benign forms of the disease.

John R Prensner
Matthew K Iyer
Arul M Chinnaiyan
Research01 Aug 2011
Nature Biotechnology

Volume: 29, P: 742-749
m6A-modified circSTX6 as a key regulator of cervical cancer malignancy via SPI1 and IL6/JAK2/STAT3 pathways

Xiaotian Han
Lingfang Xia
Xiaohua Wu
ResearchOpen Access15 Jan 2025
Oncogene

Volume: 44, P: 968-982
Spatial proximity of CD8⁺ T cells to tumor cells predicts neoadjuvant therapy efficacy in breast cancer

Hongling Liang
Jianqing Huang
Xuchao Zhang
ResearchOpen Access10 Feb 2025
npj Breast Cancer

Volume: 11, P: 1-10
Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits

Kaizhong Xue
Bo Gao
Chunshui Yu
Research22 Sept 2023
Molecular Psychiatry

Volume: 28, P: 4853-4866
Identification of the mitochondrial protein POLRMT as a potential therapeutic target of prostate cancer

Xiaojun Li
Linya Yao
Ting Jiang
ResearchOpen Access10 Oct 2023
Cell Death & Disease

Volume: 14, P: 1-13
UrbanEV: An Open Benchmark Dataset for Urban Electric Vehicle Charging Demand Prediction

Han Li
Haohao Qu
Wenqi Fan
ResearchOpen Access28 Mar 2025
Scientific Data

Volume: 12, P: 1-10
SC912 inhibits AR-V7 activity in castration-resistant prostate cancer by targeting the androgen receptor N-terminal ___domain

Qianhui Yi
Xiaojun Han
Jian Hui Wu
Research26 Mar 2024
Oncogene

Volume: 43, P: 1522-1533
Genome-wide association study reveals the genetic determinism of growth traits in a Gushi-Anka F₂ chicken population

Yanhua Zhang
Yuzhe Wang
Xiangtao Kang
ResearchOpen Access28 Sept 2020
Heredity

Volume: 126, P: 293-307
Venetoclax combined with three-day multi-frequency decitabine (DEC3-VEN) in elder or intensive chemotherapy ineligible patients with newly diagnosed acute myeloid leukemia

Xiaohui Suo
Xiaojun Ma
Yingchang Mi
CorrespondenceOpen Access20 Nov 2024
Blood Cancer Journal

Volume: 14, P: 1-3
Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy

Nicholas D. Henkel
Marissa A. Smail
Rammohan Shukla
ResearchOpen Access27 Sept 2021
Scientific Reports

Volume: 11, P: 1-14
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex

Arul Chinnaiyan and colleagues report that the long noncoding RNA SChLAP1 is overexpressed in a subset of prostate cancers and predicts poor outcome. Mechanistically, they show that SChLAP1 promotes invasiveness and metastasis and antagonizes the functions of the SWI/SNF chromatin-remodeling complex.

John R Prensner
Matthew K Iyer
Arul M Chinnaiyan
Research29 Sept 2013
Nature Genetics

Volume: 45, P: 1392-1398
Transcriptome sequencing to detect gene fusions in cancer

Using a combination of new generation long- and short-read sequencing technologies, this study analyses cancer samples for gene fusion transcripts. The approach uncovers transcripts arising from known gene fusions in leukaemia and prostate cancer, as well as newly discovered ones in prostate cancer.

Christopher A. Maher
Chandan Kumar-Sinha
Arul M. Chinnaiyan
Research11 Jan 2009
Nature

Volume: 458, P: 97-101
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

Distinct translocation mechanisms and additional translocation partners for ETS genes are found in prostate cancer. This study also provides the first functional evidence that ETS gene deregulation can promote cancer cell invasion in cell lines and pre-malignant prostate lesions in a transgenic mouse model.

Scott A. Tomlins
Bharathi Laxman
Arul M. Chinnaiyan
Research02 Aug 2007
Nature

Volume: 448, P: 595-599
Thrombin induces morphological and inflammatory astrocytic responses via activation of PAR1 receptor

Xiaojun Chen
Han Zhang
Yongjun Wang
ResearchOpen Access11 Apr 2022
Cell Death Discovery

Volume: 8, P: 1-9
Screening and identification of genes related to ferroptosis in keratoconus

Xiaojun Wu
Qing Deng
Yuxue Xu
ResearchOpen Access25 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
The Fe–S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth

Xiaojun Ren
Jimei Yan
Jianxin Lyu
ResearchOpen Access25 Jul 2023
Cell Discovery

Volume: 9, P: 1-18
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

Small-molecule compounds that target the BET ___domain in proteins such as BRD4 have recently been identified as potential anticancer agents; here, the efficacy of the BRD4-targeting compound JQ1 is demonstrated in castration-resistant prostate cancer driven by deregulated androgen receptor action.

Irfan A. Asangani
Vijaya L. Dommeti
Arul M. Chinnaiyan
Research23 Apr 2014
Nature

Volume: 510, P: 278-282
Thrombopoietin level predicts the response to avatrombopag treatment for persistent thrombocytopenia after haploidentical haematopoietic stem cell transplantation

Haixia Fu
Meng Lv
Xiaohui Zhang
Research07 Sept 2023
Bone Marrow Transplantation

Volume: 58, P: 1368-1376
Dynamic alternations of three-dimensional chromatin architecture contribute to phenotypic characteristics of breast muscle in chicken

A Hi-C study reveals the dynamic chromatin architecture of breast muscle and gene expression affected by breed-specific 3D genome architecture that may influence muscle growth and intramuscular fat deposition between fast-growing and slow-growing chickens.

Zhang Wang
Weihua Tian
Xiaojun Liu
ResearchOpen Access28 Jul 2024
Communications Biology

Volume: 7, P: 1-16
Heterologous mogrosides biosynthesis in cucumber and tomato by genetic manipulation

Sweet vegetables are developed by introducing mogroside V synthase genes into cucumber and tomato using a multigene expression system based on In-fusion technology and self-cleaving 2A peptides.

Jingjing Liao
Tingyao Liu
Xiaojun Ma
ResearchOpen Access17 Feb 2023
Communications Biology

Volume: 6, P: 1-12
How nursing students’ risk perception affected their professional commitment during the COVID-19 pandemic: the mediating effects of negative emotions and moderating effects of psychological capital

Junlong Li
Changping Huang
Jay Pan
ResearchOpen Access04 May 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-9
From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism

Mengyuan Lyu
Jian Zhou
Binwu Ying
ResearchOpen Access24 Feb 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-14
Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence

Smartphone-based mobile health platforms have drawn increasing attention from researchers developing point-of-care testing devices. Here the authors summarize recent progress and future directions of approaches combining microfluidics and artificial intelligence.

Bangfeng Wang
Yiwei Li
Bi-Feng Liu
ReviewsOpen Access11 Mar 2023
Nature Communications

Volume: 14, P: 1-18
PACT promotes the metastasis of basal-like breast cancer through Rac1 SUMOylation and activation

Luyao Wei
Wantao Wang
Zun-Ji Ke
Research16 Aug 2022
Oncogene

Volume: 41, P: 4282-4294
Predicting the loss of hepatitis B surface antigen following haematopoietic stem cell transplantation in patients with chronic HBV infection

Xueyan Sun
Haixia Fu
Xiaohui Zhang
Research01 Dec 2022
Bone Marrow Transplantation

Volume: 58, P: 265-272
DMDRMR promotes angiogenesis via antagonizing DAB2IP in clear cell renal cell carcinoma

Yumeng Zhu
Xiaojun Liu
Shan Gao
ResearchOpen Access13 May 2022
Cell Death & Disease

Volume: 13, P: 1-12
The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ

Rongfei Wei
Xiao Han
Damo Xu
Research27 Oct 2023
Cellular & Molecular Immunology

Volume: 20, P: 1428-1444
Differences in diacylglycerol acyltransferases expression patterns and regulation cause distinct hepatic triglyceride deposition in fish

Two diacylglycerol acyltransferases were shown to be differently regulated in large yellow croaker and rainbow trout. While DGAT1 is increased upon oleic acid treatment more in croaker than in trout, DGAT2 showed no significant expression difference.

Xiaojun Xiang
Renlei Ji
Qinghui Ai
ResearchOpen Access19 Apr 2024
Communications Biology

Volume: 7, P: 1-12
Whole transcriptome profiling reveals a lncMDP1 that regulates myogenesis by adsorbing miR-301a-5p targeting CHAC1

“A transcriptome study of chicken primary myoblast proliferation and differentiation shows that the lncMDP1/miRNA-301a-5p/CHAC1 axis plays an important role in skeletal muscle development.“

Bingjie Chen
Hanfang Cai
Zhuanjian Li
ResearchOpen Access02 May 2024
Communications Biology

Volume: 7, P: 1-14
An investigation of the flexural behaviour of large-span prestressed and steel-reinforced concrete slabs

Tiancheng Han
Shuting Liang
Jian Yang
ResearchOpen Access03 Jul 2023
Scientific Reports

Volume: 13, P: 1-20
miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia

Han Zhong Pei
Zhiyong Peng
Yun Chen
ResearchOpen Access15 Jul 2023
Cell Death Discovery

Volume: 9, P: 1-12
External validation of the predictive scoring systems for molecular responses in chronic myeloid leukaemia receiving initial imatinib-therapy

Feiyang Qi
Xiaoshuai Zhang
Qian Jiang
Research29 Jul 2023
Leukemia

Volume: 37, P: 1922-1924
Correction: Corrigendum: Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China

Qi Zhang
Yun Liao
Lanlan Wang
Amendments and CorrectionsOpen Access29 Jan 2016
Scientific Reports

Volume: 6, P: 1
C5aR1-positive neutrophils promote breast cancer glycolysis through WTAP-dependent m6A methylation of ENO1

Baochi Ou
Yuan Liu
Jingjie Zhang
ResearchOpen Access26 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-11
Association of left ventricular ejection fraction with risk of cardiovascular diseases: a prospective cohort study

Jun Xiao
Han Wu
Wuqing Huang
ResearchOpen Access24 Oct 2024
Scientific Reports

Volume: 14, P: 1-9
Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses

Xiaojun Lin
Qiuyi Sun
Xiaochun Bai
Research06 Aug 2018
Mucosal Immunology

Volume: 11, P: 1663-1673

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