Nature Search

LncRNA CTD-2555A7.2 promotes bone formation with LncRNA-specific cascade amplification strategy

Fanjin Meng
Kaiyuan Zheng
Chong Yin
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-17
Landscapes of immunoglobulin heavy-chain gene repertoire and its cytogenetic abnormalities in Chinese patients with multiple myeloma

Yanlei Gong
Tingting Tao
Li Yao
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Transgenic rice plants harboring an introduced potato proteinase inhibitor II gene are insect resistant

Xiaolan Duan
Xiaogang Li
Ray Wu
Research01 Apr 1996
Nature Biotechnology

Volume: 14, P: 494-498
Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway

Congenital scoliosis is a complex genetic disorder characterized by vertebral malformation. Here, the authors demonstrate that loss of dstyk leads to scoliosis in zebrafish due to dysregulated biogenesis of notochord vacuoles and that DSTYK is required for lysosome biogenesis through mTORC1 regulation.

Xianding Sun
Yang Zhou
Lin Chen
ResearchOpen Access24 Jan 2020
Nature Communications

Volume: 11, P: 1-17
m⁵C modification of mRNA serves a DNA damage code to promote homologous recombination

Post-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m⁵C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.

Hao Chen
Haibo Yang
Li Lan
ResearchOpen Access05 Jun 2020
Nature Communications

Volume: 11, P: 1-12
Water uptake of solids and its impact on ion transport

The uptake of water by polar solids can modify electrical and mass transport properties. This Review discusses hydration mechanisms and surveys case studies of the effects water uptake has on transport properties in different materials.

Markus Joos
Xiaolan Kang
Joachim Maier
Reviews31 Mar 2025
Nature Materials

Volume: 24, P: 821-834
Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair

Aberrant expression of Synaptonemal complex protein 2 (SYCP2) in breast and ovarian cancers is associated with resistance to drugs targeting the DNA damage response. Here the authors show that SYCP2 confers drug resistance by promoting R-loop formation during transcription-coupled homologous recombination.

Yumin Wang
Boya Gao
Li Lan
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-17
BVES downregulation in non-syndromic tetralogy of fallot is associated with ventricular outflow tract stenosis

Yan Shi
Yongqing Li
Wuzhou Yuan
ResearchOpen Access25 Aug 2020
Scientific Reports

Volume: 10, P: 1-12
An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy

The use of immunostimulatory agents to enhance the efficacy of chemotherapy is a promising strategy in cancer therapy. Here, the authors report on a micellar nanoparticle that can effectively co-deliver chemo- and immunotherapeutics, resulting in an improved in vivoantitumour response.

Yichao Chen
Rui Xia
Song Li
ResearchOpen Access07 Nov 2016
Nature Communications

Volume: 7, P: 1-12
RETRACTED ARTICLE: SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin

Ceruloplasmin has an important role in the stabilization and nuclear transport of HIF-1α, thus regulating VEGF expression. Here the authors show that the transcription factor SARI reduces colorectal cancer growth and angiogenesis in vivoby inducing the degradation of ceruloplasmin, thereby inhibiting the HIFα/VEGF axis.

Lei Dai
Xueliang Cui
Hongxin Deng
ResearchOpen Access29 Jun 2016
Nature Communications

Volume: 7, P: 1-15
PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

PARP1, in addition to its role in DNA repair, has a role in regulating gene transcription via PARylation of target proteins. Here the authors show that HuR is targeted after lipopolysaccharide exposure to regulate the inflammatory gene expression at post-transcriptional level.

Yueshuang Ke
Yanlong Han
Xianlu Zeng
ResearchOpen Access08 Mar 2017
Nature Communications

Volume: 8, P: 1-16
BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells

Xin Zhang
Yi Liu
Hongxin Deng
ResearchOpen Access15 Jan 2021
Oncogene

Volume: 40, P: 1516-1530
Rtt105 regulates RPA function by configurationally stapling the flexible domains

The single stranded DNA binding protein RPA coordinates DNA metabolism using multiple protein and DNA interaction domains. Here, the authors show that the chaperone-like protein Rtt105 staples RPA domains to prevent untimely protein interactions.

Sahiti Kuppa
Jaigeeth Deveryshetty
Edwin Antony
ResearchOpen Access02 Sept 2022
Nature Communications

Volume: 13, P: 1-16
Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus

Hongjing Gu
Zhengde Xie
Penghui Yang
ResearchOpen Access27 Jan 2016
Scientific Reports

Volume: 6, P: 1-10
A formula based on autonomic test using EZSCAN and anthropometric data for diagnosis of DM in China

Xiaolan Zhao
Alexander Getmanenko
Chunyan Yao
ResearchOpen Access17 Mar 2020
Scientific Reports

Volume: 10, P: 1-7
Microscopic damage evolution and physical–mechanical behavior of high-temperature red sandstone under varying heating and cooling durations

Mingze Qin
Yue Su
Nan Qin
ResearchOpen Access31 Jan 2025
Scientific Reports

Volume: 15, P: 1-25
Machine learning for early diagnosis of Kawasaki disease in acute febrile children: retrospective cross-sectional study in China

Wei Zheng
Shiben Zhu
Xufang Li
ResearchOpen Access25 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
The roles and implications of RNA m⁶A modification in cancer

Dysregulation of N⁶-methyladenosine (m⁶A), the most prevalent internal modification in eukaryotic mRNA, is common in various cancer types. The authors of this Review provide an overview of the mechanisms of m⁶A-dependent RNA regulation, summarize current knowledge of their pathological effects and potential utility as biomarkers in cancer, and describe ongoing efforts to develop small-molecule inhibitors of oncogenic m⁶A modifiers.

Xiaolan Deng
Ying Qing
Jianjun Chen
Reviews23 May 2023
Nature Reviews Clinical Oncology

Volume: 20, P: 507-526
Saliva-derived microcosm biofilms grown on different oral surfaces in vitro

Xiaolan Li
Lin Shang
Dong Mei Deng
ResearchOpen Access09 Sept 2021
npj Biofilms and Microbiomes

Volume: 7, P: 1-8
Identification of a Flavonoid Glucosyltransferase Involved in 7-OH Site Glycosylation in Tea plants (Camellia sinensis)

Xinlong Dai
Juhua Zhuang
Tao Xia
ResearchOpen Access19 Jul 2017
Scientific Reports

Volume: 7, P: 1-14
An Andrias davidianus derived composite hydrogel with enhanced antibacterial and bone repair properties for osteomyelitis treatment

Chong Yin
Meng Deng
Bin Guo
ResearchOpen Access19 Oct 2024
Scientific Reports

Volume: 14, P: 1-17
TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition

Yuan Wang
Shuang Chen
Hongxin Deng
ResearchOpen Access25 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-15
Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN

Bone marrow mesenchymal stem cells (BMSC) or BMSC-derived exosome transplantation improves rat ovarian function after chemotherapy-induced ovarian failure. Furthermore, transfer of miR-144-5p using BMSC-derived exosomes decreases granulosa cell (GCs) apoptosis via the PTEN pathway. Thus, a cell-free therapeutic strategy may be possible for ovarian failure.

Meiling Yang
Li Lin
Xiaolan Zhu
Research19 Sept 2019
Laboratory Investigation

Volume: 100, P: 342-352
Parkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma

Xiaolan Zhang
Chun Lin
Jinbao Liu
ResearchOpen Access26 Sept 2019
Cell Death & Disease

Volume: 10, P: 1-13
Riemerella anatipestifer AS87_RS09170 gene is responsible for biotin synthesis, bacterial morphology and virulence

Xiaomei Ren
Xiaolan Wang
Shengqing Yu
ResearchOpen Access02 Oct 2018
Scientific Reports

Volume: 8, P: 1-13
NF-κB pathway link with ER stress-induced autophagy and apoptosis in cervical tumor cells

Xiaolan Zhu
Li Huang
Shuilong Leng
ResearchOpen Access11 Sept 2017
Cell Death Discovery

Volume: 3, P: 1-8
A new type of homodiploid fish derived from the interspecific hybridization of female common carp × male blunt snout bream

Shi Wang
Xiaolan Ye
Shaojun Liu
ResearchOpen Access23 Jun 2017
Scientific Reports

Volume: 7, P: 1-12
Analysis of accumulation patterns and preliminary study on the condensation mechanism of proanthocyanidins in the tea plant [Camellia sinensis]

Xiaolan Jiang
Yajun Liu
Tao Xia
ResearchOpen Access04 Mar 2015
Scientific Reports

Volume: 5, P: 1-15
Serum trace metal association with response to erythropoiesis stimulating agents in incident and prevalent hemodialysis patients

Michael E. Brier
Jessica R. Gooding
Michael L. Merchant
ResearchOpen Access19 Nov 2020
Scientific Reports

Volume: 10, P: 1-13
Kidney podocyte-associated gene polymorphisms affect tacrolimus concentration in pediatric patients with refractory nephrotic syndrome

Xiaolan Mo
Jiali Li
Min Huang
Research06 Jan 2020
The Pharmacogenomics Journal

Volume: 20, P: 543-552
Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination

Xiaolan Liu
Yueshuo Li
Ya Cao
ResearchOpen Access19 Jan 2018
Cell Death & Disease

Volume: 9, P: 1-14
A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma

Wei Zhu
Zhiming Zhang
Jinlin Hou
ResearchOpen Access20 Apr 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-16
Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Zuqiang Wang
Hangang Chen
Yangli Xie
ResearchOpen Access05 Jan 2022
Bone Research

Volume: 10, P: 1-16
Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

Andrew R. Stothert
Amirthaa Suntharalingam
Chad A. Dickey
ResearchOpen Access20 Dec 2017
Scientific Reports

Volume: 7, P: 1-9
ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription

High expression of the transcription factor ETS2 plays important role in a mouse model of renal fibrosis and in TGF-β1-treated human tubular epithelial cells (HK2). ETS2 promotes TGF-β1-induces epithelial-to-mesenchymal transition (EMT) phenotypic inversion and the expression of EMT markers in HK2 cells by enhancing transcription of JUNB. These findings suggest that ETS2 could be a novel target for the prevention the progression of renal fibrosis.

Fang Yao
Xiaojing Wang
Xiaochun Bai
Research22 Oct 2019
Laboratory Investigation

Volume: 100, P: 438-453
Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis

Hong Wei
Yuhao Xu
Yuefeng Li
ResearchOpen Access27 Apr 2020
Cell Death & Disease

Volume: 11, P: 1-11
Resveratrol enhances brown adipose tissue activity and white adipose tissue browning in part by regulating bile acid metabolism via gut microbiota remodeling

Suocheng Hui
Yang Liu
Mantian Mi
Research17 Mar 2020
International Journal of Obesity

Volume: 44, P: 1678-1690
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities

Qiang Zeng
Dongfang Li
Wenkui Dai
ResearchOpen Access17 Sept 2019
Scientific Reports

Volume: 9, P: 1-10
A new, easily generated mouse model of diabetic kidney fibrosis

Xiaolin He
Tianzhou Zhang
Darren A. Yuen
ResearchOpen Access29 Aug 2019
Scientific Reports

Volume: 9, P: 1-12
Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2 and autophagy pathways

Qian Zhou
Bin Chen
Peng Cao
ResearchOpen Access24 Aug 2016
Scientific Reports

Volume: 6, P: 1-12
Timosaponin AIII induces antiplatelet and antithrombotic activity via Gq-mediated signaling by the thromboxane A2 receptor

Yue Cong
Limei Wang
Yuwen Cong
ResearchOpen Access09 Dec 2016
Scientific Reports

Volume: 6, P: 1-13
Resveratrol Treatment after Status Epilepticus Restrains Neurodegeneration and Abnormal Neurogenesis with Suppression of Oxidative Stress and Inflammation

Vikas Mishra
Bing Shuai
Ashok K. Shetty
ResearchOpen Access07 Dec 2015
Scientific Reports

Volume: 5, P: 1-19
The musk chemical composition and microbiota of Chinese forest musk deer males

Diyan Li
Binlong Chen
Jessica Satkoski Trask
ResearchOpen Access08 Jan 2016
Scientific Reports

Volume: 6, P: 1-10
Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice

Siru Zhou
Yangli Xie
Lin Chen
ResearchOpen Access04 Apr 2016
Scientific Reports

Volume: 6, P: 1-13
Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB

Xiaolan Cui
Qian Chen
Qiang Xia
ResearchOpen Access06 Oct 2016
Cell Death & Disease

Volume: 7, P: e2403
A portal vein cannulation technique for drug discovery in mice

Xiaolan Shen
Zuliang Yao
Xinchun Tong
Special Features01 Jan 2008
Lab Animal

Volume: 37, P: 41-44
A longitudinal resource for population neuroscience of school-age children and adolescents in China

Xue-Ru Fan
Yin-Shan Wang
Xi-Nian Zuo
ResearchOpen Access21 Aug 2023
Scientific Data

Volume: 10, P: 1-24
Built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis

Two parallel semiconducting TiO₂ zones, anatase and rutile, are made to have lower and higher electron densities, respectively, and form periodically organized junctions through anatase–rutile-phase transition in selective areas by laser irradiation on the titanium bone implants. The periodic junctions result in the formation of a periodic microscale electric field (MEF), built-in on the implants, which in turn efficiently induces and promotes osteogenesis.

Chengyun Ning
Peng Yu
Chuanbin Mao
ResearchOpen Access04 Mar 2016
NPG Asia Materials

Volume: 8, P: e243

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