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Atomically dispersed metallic materials attract tremendous attention. Here the authors explore a general method based on the discrepancy in cohesive energy of the metals to synthesize a large library of bi-/multi-metallic single atom/atomic cluster materials for electrocatalytic hydrogen evolution.

Proton exchange membrane water electrolysers require the development of active, stable and cost-effective catalysts for water oxidation. Now, a Ru/α-MnO₂ catalyst with in-situ-formed arrays of Ru atoms is presented for acidic water oxidation, which follows the oxide path mechanism and achieves enhanced activity and stability.

Differential spectrometers recognise different wavelength via their differential photodetector responsivity. The authors combine an 8-pixel hemispherical perovskite photodetector with neural network algorithms to realise 3D trajectory tracking and 2D ___location tacking with colour classification.

Organic nitrogen (N) sources management is critical to achieve high rice yield and carbon (C) neutrality. This study scaled up the field findings using machine learning and showed that the co-benefits of improved rice yield and reduced net C emission can be realized with integrated management of organic N and water on a global scale.

Identifying and quantifying the biodistribution of synthetic polymeric nanoparticles in biological milieu is crucial for biomedical applications. Now, it has been shown that encoded polymeric amphiphiles with discrete molar masses undergo sequence- and length-dependent self-assembly into precise digital micelles that can be used in direct sequence reading and ex vivo label-free quantification assays.

Most cases of craniofacial microsomia are sporadic but familial cases have been reported. Here the authors report that variants in FOXI3 can cause a small fraction of cases with different modes of inheritance including autosomal dominant with reduced penetrance.

By selectively erasing the nonlinear coefficients in a lithium niobate crystal using a femtosecond laser, a 3D nonlinear photonic crystal, with an effective conversion efficiency comparable to that of the typical quasi-phase-matching processes, is demonstrated.

This study analyses radio observations of the jet in galaxy M87, from which the existence of a spinning black hole that induces Lense–Thirring precession of a misaligned accretion disk is inferred.

The authors investigate junctions made of two flakes of the cuprate superconductor Bi₂Sr_2-xLa_xCuO_6+y (Bi2201) twisted by 45 degrees. They find evidence for an isotropic pairing component, and call into question theoretical predictions of d+id superconductivity in this system.

The fabrication of perovskite solar cells in ambient air is of interest, but the materials are unstable in the presence of moisture. Yan et al. show that guanabenz acetate salt eliminates vacancy defects that trigger perovskite degradation, enabling 25% efficiency devices to be fabricated in air.

Good impalement resistance, mechanical robustness and weather resistance are essential for applications of superhydrophobic coatings. Here, the authors achieve scalable preparation and practical application of robust superhydrophobic coatings for preventing rain attenuation of 5G/weather radomes.

Patients treated for multiple myeloma often experience relapse due to antigen loss, thus necessitating the identification of additional therapeutic targets. In this study, the authors demonstrate that FcRH5 is expressed on MM cells and can be targeted using chimaeric antigen receptor T cells in mice.

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

Cytotoxic CD8⁺ T cells specific for α-myosin are identified as pivotal players in myocarditis associated with immune checkpoint inhibitor anticancer therapies.

The researchers showcased a negative Goos-Hänchen effect in film samples across the entire visible spectrum and discovered an amber rainbow ribbon and an optical black hole where little light leaks out due to perfect back reflection.

The NLRP3 inflammasome plays a pivotal role in clearing viral respiratory infection, but the molecular mechanism is not fully known. Here authors show that acetate, produced by gut bacteria, may enhance NLRP3-mediated type I interferon production following influenza infection in mice.

The development of Ni-rich layered lithium transition metal oxides is plagued by their voltage and capacity fading on battery cycling. Here, the authors demonstrate an effective approach to treat these problems by infusing a solid electrolyte into the grain boundaries of the secondary particles of these layered materials.

Ligand-gated ion channels can be desensitized to control signalling outputs. This study reports the calmodulin-mediated, Ca²⁺-dependent desensitization of plant GLR channels, revealing a negative feedback loop in the orchestration of plant systemic wound responses.

The authors report a controllable third-order cusp singularity in the phase-tracked closed-loop oscillation of two coupled mechanical modes. This finding addresses the challenge of constructing and controlling higher-order singularities.

In this study, Qin et al. present a murine-adapted SARS-CoV-2 strain, MASCp36, as a model for studying the pathogenicity, evolution and adaptation of the virus to human and animal hosts.

Here, the authors show that PDHE1α accumulates at DNA double-strand breaks, in a PARylation-dependent manner, where it locally supplies acetyl-CoA for histone acetylation. These events facilitate remodeling of the chromatin landscape and efficient repair.

Energy harvesting by utilizing optical control has emerged as a promising solution to alleviate energy and environmental crisis. However, it is challenging to realise nano-scale energy storage and conversion in the same material. Here the authors report a nonferroelectric molecular [CoGa] crystal that uses light as an external stimulus to exhibit photoenergy conversion and energy storage properties.

In glioma STAT3 signaling contributes to gliomagenesis. Here, the authors show that Smad6 expression correlates with poor survival and is overexpressed in glioma cells, and regulates STAT3 activity via negatively regulating PIAS3.

Metal-mediated self-assembly in solution typically leads to small two- and three-dimensional architectures on scales smaller than 10 nm, but now a series of large, discrete, two-dimensional supramolecular hexagonal grids have been prepared through a combination of intra- and intermolecular coordination interactions. These 20-nm-wide grids have been imaged at submolecular resolution using scanning tunnelling microscopy.

Star motifs are ubiquitous throughout nature and in man-made architectures, but their molecular level design remains challenging. Here the authors present a stepwise approach to self-assemble pentagonal and hexagonal star-shaped metallo-architectures through the careful design of metallo-organic ligands.

The innate immune response to many RNA viruses depends on recognition of viral RNA by RIG-I. Here the authors show that, upon virus infection, FBXW7 interacts with RIG-I and inhibits ubiquitin-mediated degradation of RIG-I, resulting in increased interferon signallingin vitro and in vivo.

Mechanically interlocked molecules are extensively applied as artificial molecular machines but rotaxane-branched dendrimers are rarely explored because of synthetic challenges. Here the authors present the construction of dual stimuli-responsive rotaxane-branched dendrimer which can be stimulated by DMSO or acetate ions.