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This study reveals that α-lipoic acid (ALA) is reduced in aged mouse and human intestine and ALA supplementation reduces aging hallmarks. Paneth cells play a role in the effects of ALA.

Topological photonic structures enable robust light transport but face coupling challenges. The authors demonstrate transverse spin matching governs the coupling between the topological waveguide and waveguide, achieving 96.3% theoretical and 94.2% experimental transmission efficiencies.

Safety is only one side of the coin for aqueous batteries. Here the authors show a water-in-polymer electrolyte that shows a wide electrochemical window and salt recyclability, thus addressing challenges at the other side.

Preclinical characterization of the SARS-CoV-2 M^pro inhibitor RAY1216 shows improved in vivo pharmacokinetics compared with nirmatrelvir.

Polynary perovskite oxides are promising air electrodes for rSOCs, with configuration entropy (S_config) often linked to reactivity. However, high S_config alone does not strongly correlate with performance. This study develops a model identifying key descriptors to guide high-activity oxide discovery.

Trees enrich cities, contributing to urban ecosystems and to the health of urban populations. This study quantifies urban tree coverage in all major Chinese cities, finding that greening efforts are successful but that certain mega-cities are benefiting more.

Engineering macrophages to express chimeric antigen receptors (CARs) for targeted tumor cell phagocytosis has shown encouraging results. Here the authors engineer macrophages with enhanced synthetic phagocytosis receptors which incorporate a FcRɣ-driven phagocytosis CAR and an auto-secreted CD47 blocker, showing improved anti-tumor efficacy

Dendritic computing is a promising approach to enhance the processing capability of artificial neural networks. Here, the authors report the development of a neurotransistor based on a vertical dual-gate electrolyte-gated transistor with short-term memory characteristics, a 30 nm channel length, a low read power of ~3.16 fW and read energy of ~30 fJ for dendritic computing.

Difficulties in propagating HRV-C have hindered our understanding of this common respiratory pathogen. Here, authors developed an organoid-based system to reproducibly propagate HRV-C and characterized HRV-C infection in physiologically active respiratory organoids.

Excessive glucocorticoid (GC) action is linked to various metabolic disorders. Here the authors show that elevated expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), the enzyme driving local bone GC activation, is associated with bone loss and obesity mice.

Processing heterogeneous visual data in edge-side intelligent machines is complex and inefficient. Here, the authors propose a hardware-software co-designed system using random resistive memory, achieving significant energy efficiency and training cost reductions.

Functionalising porous materials is a route to enhancing properties of hybrid materials. Here authors present a “Cage-on-MOF” strategy to modify the surface of mesoporous MOFs by using molecular cages to achieve selective dyes adsorption behavior and heterogeneous catalysis.

Hao, Shen and colleagues identify and characterize two distinct types of myeloid–B cell interaction that may signal solid tumour-induced immunosuppression and can correlate with complete responses to immunotherapy in patients with breast cancer.

This study presents a neuromorphic computing platform capable of learning cross-modal, event-driven signals for efficient real-time knowledge generalization. It also achieves zero-shot transfer learning for multimodal data.

Aging increases the risk for Alzheimer’s disease (AD). Here, the authors present a spatial transcriptome atlas of the human prefrontal cortex in AD, revealing distinct transcriptional alterations.

Understanding the sensing mechanism of metal oxide semiconductors is imperative for developing high-performance sensors. Here, the participation of lattice oxygen, caused by additional Ge, boosts the hydrogen sensing ability of SnO₂.

Non-alcoholic fatty liver disease is a growing health burden with limited treatment options worldwide. Herein the authors report a randomized, double-blind, placebo-controlled, multiple-dose trial of a first-in-class pan-phosphodiesterase inhibitor ZSP1601 in NAFLD patients.

Nonalcoholic steatohepatitis (NASH) is a heterogeneous disease with complicated pathogenesis. Here the authors identify that the E3 ligase TRIM26 confers protection against NASH development via suppression of CCAAT/enhancer binding protein delta (C/EBPδ).

Congenital vertebral malformation has a complex genetic architecture that isn’t fully understood. Here, the authors explore the genetic architecture of congenital vertebral malformation through case-control rare variant genetic analyses and embryonic transcriptome analyses of the developing spine.

Three-dimensional computing-in-memory circuits based on vertical resistive random-access memory and complementary metal–oxide–semiconductor technologies can be used to create efficient hardware for artificial neural networks.

Breast cancer amplified sequence 2 (BCAS2) is involved in pre-mRNA splicing but its physiological role is unclear. Here, the authors find BCAS2 enriched in mice spermatogonia in the testes, and BCAS2 deletion in germ cells alters alternative splicing of spermatogenesis-related genes, causing male infertility.

Co-designing hardware platforms and neural network software can help improve the computational efficiency and training affordability of deep learning implementations. A new approach designed for graph learning with echo state neural networks makes use of in-memory computing with resistive memory and shows up to a 35 times improvement in the energy efficiency and 99% reduction in training cost for graph classification on large datasets.

Rad5 is a hub connecting three replication stress tolerance pathways. Here, the authors present the 3.3 Å crystal structure of a N-terminal truncated K.lactis Rad5 construct that reveals the spatial arrangement of the HIRAN, Snf2 and RING domains and structure-guided in vitro and in vivo experiments reveal multiple activities of the yeast Rad5 HIRAN ___domain among them a role in binding PCNA and supporting its ubiquitination.

Common approaches for carbon dioxide capture include absorption in amine solutions or adsorption in porous materials. Here, the authors combine these two strategies and report carbon dioxide capture in a slurry of metal-organic frameworks in glycol-2-methylimidazole, which has advantages of both techniques.

This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.

While splitting water may provide a renewable source of carbon-neutral energy, the water oxidation half-reaction is sluggish and the materials needed show poor stability. Here, authors demonstrate an unusual iridium-based oxide to perform high-efficiency oxygen evolution in acid with good stability.

Earth-abundant water splitting materials are highly desirable for renewable fuel production, but such catalysts are rarely tested for long-term use. Here, the authors prepare active water-splitting electrocatalysts via corrosion engineering that are stable for thousands of hours.

Designing reliable, scalable and high speed computing systems remains a challenge. Here, the authors identify noncentrosymmetric orthorhombic phase in HZO film and demonstrate a CMOS compatible 3D Vertical HZO-based ferroelectric diode array with self-selective property and 20 ns of speed operation.

Greenhouses are quickly proliferating in response to the world’s increasing demand for food, but information on their precise ___location, distribution and extent remains limited in many countries. This Analysis combines global very-high-resolution satellite imagery and artificial intelligence to address this knowledge gap, showing a dramatic increase in greenhouse coverage in the Global South.