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The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

DNA Damage Regulated Autophagy Modulator 1 (DRAM1) plays pivotal roles in autophagy regulation. Here, the authors show that DRAM1 stabilizes lysosomal VAMP8, thereby promoting autolysosome maturation. Furthermore, they establish that DRAM1–VAMP8 axis enhances autophagic flux and facilitates hepatocellular carcinoma extravasation, as validated in both zebrafish xenograft and mouse metastatic models.

Torpor is an adaptive hypometabolic state in response to energy scarcity. Here, Cheng et al. show that catecholaminergic neurons in the ventrolateral medulla induce torpor in mice by lowering body temp and heart rate (heart rate decline precedes cooling).

Neural mechanisms underlying sensory and motor control are not fully understood. Here authors identify two distinct neuron groups in the primary sensorimotor cortex (SM1) that mediate descending pain inhibition via brainstem-spinal circuits. Silencing these neurons disrupts motor-induced analgesia but not basic sensation, uncovering a motor-driven pain control pathway.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Single-atom catalysts (SACs) are potent tools for Fenton catalysis. However, current SACs face limitations due to the specificity of their supports. Here, the authors synthesised CoSAs-ZnO, that can selectively generate sulfate radicals and singlet oxygen in peroxymonosulfate and peracetic acid systems, respectively.

A newly identified coronavirus isolated from farmed minks can use the receptor ACE2 to infect cells of different mammalian species, including human cells, which has implications for potential zoonotic spillover events.

This research highlights the role of a KNOX1 transcription factor in stalling receptacle growth in cucumber, leading to bisexual flowers with superior ovaries like those in tomatoes. These insights enhance our understanding of ovary formation and sex in cucurbits.

The immune response of immunotherapy in colorectal cancer remains low and new adjuvant targets are in demand. By in vivo CRISPR-Cas9 screening that targets membrane and secreted proteins genes, the authors identify that disrupting MBTPS1 in tumor cells upregulates STAT1-transcribed chemokines, promotes CXCR3⁺ CD8 T cells infiltration and potentiates anti-PD-1 therapy.

Lysosomes are best known for their roles in inflammatory responses via autophagy. Here, Xing et al., find that lysosomes regulate macrophage inflammatory responses by finely controlling interleukin-1β production, altering lysosomal Fe2+ release through the TRPML1 channel.

This study presents iKraph, a large-scale biomedical knowledge graph built using an award-winning natural language processing pipeline with expert-level accuracy. Using probabilistic semantic reasoning, iKraph enables automated knowledge discovery with excellent performance.

α-Pyridones and α-pyrones are ubiquitous structural motifs found in natural products and components of biologically active small molecules. Here, the authors report an oxidant-free Rh-catalyzed electrochemical divergent vinylic C–H annulation of acrylamides with alkynes to α-pyridones and cyclic imidates.

This study demonstrated that amplified ethylene signaling impairs gravitropic growth of rice roots by affecting root cap stability and OsPIN2 polar localization, whereas mechanosensing-induced calcium signaling antagonizes ethylene signaling to safeguard gravitropism.

Deformation banding is a common phenomenon in metals, when the external stress surpasses the elastic limit. Here, experiments reveal two strikingly different slip bands that result from the same origin, yet distinct evolution, in stressed advanced alloy.

ctDNA is a promising method to monitor tumor burden in triple negative breast cancer. Here, the authors show that ctDNA detection correlated with prognosis after neoadjuvant chemotherapy but not at baseline.

Whether hippocampal place cells are unique in their representation of spatial information utilized during body navigation remains unknown. Here authors report monkey cells in the premotor cortex exhibit similar position fields which encode hand position during a reaching task.

Clinical approaches for cancer therapy face several interrelated challenges. Here, Xue et al. presented an integrated wearable flexible ultrasound microneedle patch that serves as a portable platform for convenient and minimally invasive cancer therapy.

Artificial intelligence (AI) is becoming increasingly relevant to assist with oncology imaging, but diagnosing rare tumours remains challenging. Here, the authors develop an AI approach to detect rare thyroid cancer subtypes by integrating clinical knowledge with image generation based on ultrasound imaging data from large patient cohorts.

Cyclodehydrogenation is an important ring-formation reaction but the inherently high C–H bond energy necessitates high temperatures, and the ubiquity of C − H bonds in molecules hinders the selectivity. Here, the authors report a selective room-temperature cyclodehydrogenation reaction on Au(111) via radical addition of open-shell resonance structures.

Tang, Zhang, Fang, Zhu et al. identify impaired mitochondrial fusion and biogenesis as a key mechanism underlying NOTCH1-associated aortic pathology and show that correcting mitochondrial loss in mutant mice using repurposed drugs teriflunomide or leflunomide slows the progression of aoropathy.

A nitrate-induced transcription factor TaTCP6 is identified as a central regulator for the efficient and balanced utilization of nitrate and phosphorus, and a moderate increase in its expression promotes wheat yield.

The authors prepare an all-organic dielectric film with a nano-submicron surface layer via electrospinning technology, achieving a simultaneous improvement in the discharged energy density and charge/discharge efficiency.

Fabricating semiconductor devices with dimensions below 10 nm presents significant challenges. Here, Liu et al. use controlled electron irradiation to remove atoms in an MoS₂ sheet, creating Mo₅S₄nanoribbons with a uniform width of 0.35 nm and a theoretical band gap of 0.77 eV.

For bioinspired structural materials, integral preparation of multiscale structures remains challenging. The authors report a hierarchical strategy to assemble multiple micro-nano units to complex multiscale structures integrally synchronously.

A template-free magnetization strategy for inverse programming of hard-magnetic domains embedded in solvent-responsive hydrogel is reported using a photodosage-based printing method, achieving shape morphing into 3D curved surfaces under the actuation of a magnetic field.

Determinants of soil microbial community structure are less well studied. Here, Riddley et al. profile nationwide bacterial biogeographic patterns, and identify key environmental factors and distinct roles of deterministic and stochastic processes in shaping ecotype community assembly across terrestrial ecosystems.

Clarke, Hawkinson and colleagues study the contribution of glycogen accumulation in the onset and progression of lung cancer.

This genome-wide association study on persistent hepatitis B virus (HBV) infection among Chinese confirms previously associated genetic loci while discovering a novel protective locus at 8p21.3. The study also demonstrates the nearby gene INST10 suppresses HBV replication in vitro.

The conductance from bulk bands in a topological insulator usually blurs effects arising from edge states. Here, Song et al. report a Coulomb gap opened by electron–electron interactions, which effectively suppress the bulk conductance and promote observation of topological edge states in the single-layer 1T’-WTe₂.

Precise genome editing in human pluripotent stem cells requires the development of methods for rapid and efficient genetic manipulation. Here, the authors screen for small molecules that enhance CRISPR-Cpf1-mediated genome engineering.

Zhang et al. demonstrate that the smooth muscle-specific deficiency of the mitochondrial NAD⁺ transporter SLC25A51 impairs the biosynthesis of proline and type III collagen and results in thoracic and abdominal aortic aneurysm.

Solar-driven CO₂ conversion to produce solar fuels is an attractive way to harness solar energy and reduce carbon emissions. Here, the authors report two osmium complexes as highly active and selective CO₂ reduction catalysts for selective CO₂-to-methane conversion on Si-based photocathodes.

Species genomes are important for analyses of genetic variation. Wu et al. assembled a T2T genome of a male cashmere goat, including 288.5 Mb of previously unresolved regions, and identified selective variants and genes associated with domestication and cashmere traits.

The authors solved the native structure of cyanobacterial PBS–PSII supercomplex at a resolution of 3.5 Å via STAgSPA strategy, revealing the association details and possible energy transfer pathways between PBS and PSII.