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Excessive fibrosis triggered by bisphosphonates impairs fracture healing in osteoporotic bone. Here, the authors develop an injectable magnesium-alendronate MOF-based hydrogel adhesive and show it prevents fibrosis and enhances bone repair, improving healing strength in an osteoporotic rat model.

The role of human glioma IDH1 mutations in regulation of antiviral response is unclear. Here, the authors show that D2HG produced by mutant IDH1 inhibits IFN antiviral responses in glioma cells, which confers sensitivity to oncolytic virotherapy.

By means of dilation methods and employing complex eigenvalue braids, non-Hermitian non-Abelian topological transitions are identified, which give rise to a third-order exceptional point.

Achieving fairness while preserving privacy in medical imaging tasks remains a significant challenge. Here, the authors present and comprehensively evaluate a federated learning framework to tackle both fairness and privacy issues, using a flexible regularization term to integrate multiple fairness criteria.

This study uses a customized metasurface to unveil a distinct parity Hall effect in degenerate optical vectorial modes. This work realizes the advances in meta-devices and showcases new possibilities for manipulating optical fields based on parity.

Quantum teleportation offers superior performance in transmitting information over classical methods but is often hindered by environmental noise. To address this issue, the authors introduce a teleportation protocol with finite-dimensional embezzling catalysts to achieve arbitrarily high fidelity, with only negligible changes to the catalytic systems.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Propane dehydrogenation is challenging to perform under mild conditions due to the reaction’s endothermic nature. Now, near-ambient propane dehydrogenation has been shown using copper single-atom catalysts supported on titanium oxide under light illumination and a water vapour environment.

Mammary epithelial cells act to continuously renew the mammary tissue and must balance differentiation and self-renewal. Here they show that Mcam, a non-canonical Wnt pathway member, regulates communication between macrophages and mammary epithelial cells, thereby maintaining self-renewal and subsequently promoting mammary ductal morphogenesis.

A graphene-nanopocket-protected pure Pt nanocatalyst has been reported for heavy-duty-vehicle fuel cells that deliver high power density, high efficiency and exceptional durability with >200,000-h projected lifetime.

Microwave technology is crucial for communications and high-speed electronics. Wang et al. now use nitrogen-vacancy defects in diamond to measure the strength and orientation of the magnetic component of a microwave electromagnetic field on the nanoscale.

Enzymatic mimics, capable of catalysing cascading reactions under physiological conditions, can be formed from integrating multiple components. Here, the authors report a graphene–haemin–glucose oxidase system capable of biomimetic generation of antithrombotic species from abundant glucose and L-arginine.

Duan et al. show that ACE2-dependent and ACE2-independent entry of SARS-COV-2 in epithelial cells versus myeloid cells differentially regulates viral replication and inflammatory responses, thereby contributing to COVID-19 progression and pathology.

A quantum two-level system can be coherently excited by a phase-locked dichromatic electromagnetic field. This technique can make single-photon generation more efficient as the pump light does not overlap in frequency with the emitted single photons.

Single-photon sources with a single-photon efficiency of 0.60, a single-photon purity of 0.975 and an indistinguishability of 0.975 are demonstrated. This is achieved by fabricating elliptical resonators around site-registered quantum dots.

Determining glioma types directly from whole-slide images (WSIs) would be of great diagnostic utility. Here, the authors develop a deep learning model to identify diffuse glioma types from WSIs according to the 2021 WHO classification across multiple cohorts and with interpretable features.

Ruthenium dioxide exhibits good activity for the oxygen evolution reaction in acidic conditions but fails to maintain stable performance over long periods. Here, the authors report a confinement strategy that suppresses ruthenium dioxide degradation, enhancing its long-term durability.

Most of the available fluorogenic RNA approaches emit visible fluorescence, and there is a need for tools working at longer wavelengths. Here, the authors identify and modulate red fluorescent protein-like fluorophores to bind the fluorogenic RNA Squash, thereby obtaining near-infrared fluorogenic RNA-based tools.

Duplication of the MECP2 gene (encoding methyl-CpG-binding protein 2) causes MECP2 duplication syndrome. Here the authors develop a Cas13Y system capable of targeting the MECP2 mRNA for degradation and reducing protein levels in the brain of humanized MECP2-transgenic mice and nonhuman primates.

Whether, how and to what extent integrating crop production, livestock production and bioenergy systems can enhance the sustainability of specialized farming remains poorly understood at downscaled regional levels. This study quantifies life cycle impacts of agricultural integration in China, including bioenergy provision.

CrSe₂ nanosheets grown on WSe₂ show no apparent change in surface roughness or magnetic properties after months of exposure in air. Calculations suggest that charge transfer from the WSe₂ substrate and interlayer coupling within CrSe₂ play a critical role.

Here, the authors simultaneously capture dynamic Raman spectral evidence of Ru surfaces, interfacial water, *H and *OH intermediates, and the interactions between them, demonstrating the regulation of Ru valence state on interfacial water and intermediates for catalytic activity improvement.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

High fidelity manipulation of diamond-based spin qubits is difficult at room temperature because of decoherence. Here, the authors show a universal set of logic gates in nitrogen-vacancy centres with average single-qubit and two-qubit gate fidelities of 0.999952 and 0.992, respectively.

The use of lung and colonic organoid systems to assess the susceptibility of lung and gut cells to SARS-CoV-2 and to screen FDA-approved drugs that have antiviral activity against SARS-CoV-2 is demonstrated.

Symmetry reduction from T to S₄ in coordination cages enables selective recognition of higher fullerene isomers, including D₂-C₇₆, C_2v(2)-C₇₈ and C_2v(3)-C₇₈, presenting a promising approach for fullerene identification and enrichment.

Distinct activity patterns along the CA1 transverse axis during object-related event coding, as well as spatial and non-spatial contextual coding, shed light on the selective processing of information within the entorhinal-hippocampal network.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Here, the authors built a non-redundant catalogue of nearly 1 billion putative small proteins from the global microbiome as a publicly-available resource, and highlight how some highly prevalent and evolutionarily conserved sequences lack functional annotation.

Touch can positively modulate cognitive performance and emotional response. Here the authors demonstrate that enriched tactile experience improves memory and reduces anxiety in adult mice by remodelling the pathway from the primary somatosensory cortex to the dentate gyrus.

The synthesis of two-dimensional (2D) organic lateral heterostructures with desirable properties from organic single crystals remains challenging. Now, 2D organic lateral heterostructures have been produced by using a liquid-phase growth approach and vapour-phase growth method, enabling the structural inversion of organic lateral heterostructures via a two-step strategy.

Most recent SARS-CoV-2 variants showed exceptional immune evasion properties. Here, the authors identify a highly conserved epitope within the RBD targeted by a broad spectrum neutralizing antibody BA7535 that shows therapeutic antiviral potency in mouse studies.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745.

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.