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Showing 1–50 of 51 results

Advanced filters: Author: Xinquan Yang Clear advanced filters

HVAngleEst: A Dataset for End-to-end Automated Hallux Valgus Angle Measurement from X-Ray Images

Qiong Wang
Dongdong Ji
Hongmou Zhao
ResearchOpen Access30 May 2025
Scientific Data

Volume: 12, P: 1-7
Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus

This study identifies monoclonal antibodies A138 and B026 targeting MPXV proteins M1R and B6R. Both antibodies exhibit neutralization of MPXV and VACV, and their combination enhances protective efficacy in mice, supporting a dual-targeting strategy.

Yuanyuan Qu
Wanbo Tai
Gong Cheng
ResearchOpen Access01 Apr 2025
Nature Communications

Volume: 16, P: 1-16
Leveraging diverse cell death patterns in osteosarcoma patients and identification of the function of FADS2 in osteosarcoma cells

Guannan Bai
Shaobo Zhao
Wenhao Chen
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-22
Exploring distinct modes of inter-spike cross-linking for enhanced neutralization by SARS-CoV-2 antibodies

This study demonstrates that a single antibody exhibits distinct binding modes with SARS-CoV-2 WT and Omicron variants, correlating with neutralization loss. The underlying mechanisms offer insights into enhanced neutralization.

Xuanyu Nan
Yujie Li
Yuhe R. Yang
ResearchOpen Access04 Dec 2024
Nature Communications

Volume: 15, P: 1-14
Unraveling the genetic architecture of congenital vertebral malformation with reference to the developing spine

Congenital vertebral malformation has a complex genetic architecture that isn’t fully understood. Here, the authors explore the genetic architecture of congenital vertebral malformation through case-control rare variant genetic analyses and embryonic transcriptome analyses of the developing spine.

Sen Zhao
Hengqiang Zhao
Nan Wu
ResearchOpen Access06 Feb 2024
Nature Communications

Volume: 15, P: 1-9
Stepwise selection on homeologous PRR genes controlling flowering and maturity during soybean domestication

Whole-genome resequencing and association analyses in 424 soybean accessions identify two homeologous genes that contributed to flowering time adaptation during soybean domestication.

Sijia Lu
Lidong Dong
Fanjiang Kong
Research30 Mar 2020
Nature Genetics

Volume: 52, P: 428-436
ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis

Cell fate canalization is a core biological event. The authors uncover the role of ARID1A at a super-enhancer region of osteoclast lineage master transcription factor, and antagonistic action between distinct BAF complexes in the proper cell fate canalization.

Jiahui Du
Yili Liu
Xinquan Jiang
ResearchOpen Access17 Jul 2024
Nature Communications

Volume: 15, P: 1-20
Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

In this study, Qin et al. present a murine-adapted SARS-CoV-2 strain, MASCp36, as a model for studying the pathogenicity, evolution and adaptation of the virus to human and animal hosts.

Shihui Sun
Hongjing Gu
Cheng-Feng Qin
ResearchOpen Access27 Sept 2021
Nature Communications

Volume: 12, P: 1-16
Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses

The authors identify nanobodies from immunized alpaca with broadly neutralizing activity against SARS-CoV-1, SARS-CoV-2 variants, and major sarbecoviruses. One representative nanobody binds to a highly conserved epitope on RBD and protects K18-hACE2 mice from Omicron and Delta infection.

Mingxi Li
Yifei Ren
Linqi Zhang
ResearchOpen Access27 Dec 2022
Nature Communications

Volume: 13, P: 1-17
BMP restricts stemness of intestinal Lgr5⁺ stem cells by directly suppressing their signature genes

Bone morphogenetic protein (BMP) maintains intestinal homeostasis by restricting its hyperproliferation but whether it directly regulates the stem cells is unknown. Here the authors show that BMP constrains the Lgr5⁺stem cell expansion under both homeostatic and injury conditions through Smad-mediated repression of stem cell signature genes.

Zhen Qi
Yehua Li
Ye-Guang Chen
ResearchOpen Access06 Jan 2017
Nature Communications

Volume: 8, P: 1-14
An early warning signal for grassland degradation on the Qinghai-Tibetan Plateau

Livestock grazing may drive grassland degradation. Here, the authors use process-based modelling validated with empirical data to define a stocking rate threshold across grassland on the Qinghai-Tibetan Plateau, identify vulnerable areas and predict threshold shifts under future climate scenarios.

Qiuan Zhu
Huai Chen
Yanfen Wang
ResearchOpen Access12 Oct 2023
Nature Communications

Volume: 14, P: 1-13
TCP1 promotes the progression of malignant tumours by stabilizing c-Myc through the AKT/GSK-3β and ERK signalling pathways

TCP1 promotes tumour progression by disrupting the degradation of the oncogene c-Myc in the context of hepatocellular carcinoma and pancreatic ductal adenocarcinoma.

Hekun Liu
Linying Chen
Yuanzhong Chen
ResearchOpen Access04 Apr 2025
Communications Biology

Volume: 8, P: 1-13
A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus

Currently, there are no treatments or vaccines against Epstein-Barr virus (EBV) infection. Here, Zhu et al. isolate gH/gL-specific antibodies from infected donors and identify 1D8, that substantially reduces infection levels in both, B- and epithelial cells, and reduces tumor burdens in EBV-challanged humanized mice due to interferance with the gH/gL-mediated membrane fusion and binding.

Qian-Ying Zhu
Sisi Shan
Linqi Zhang
ResearchOpen Access16 Nov 2021
Nature Communications

Volume: 12, P: 1-13
Discovery of candidate functional non-coding mutations in acute myeloid leukemia using single-cell chromatin accessibility sequencing

The authors characterize the single-cell chromatin accessibility landscapes of 10 bone marrow samples from AML patients at diagnosis. They introduce a pipeline for the detection of non-coding mutations in cis-regulatory elements using scATAC-seq data.

Ming Zhu
Jiali Zhu
Jialiang Huang
ResearchOpen Access26 May 2025
Communications Biology

Volume: 8, P: 1-13
Ultra-durable superhydrophobic cellular coatings

The design and scalable fabrication of durable superhydrophobic coatings that prevent accretion of matter is challenging. Here the authors developed a generic cellular design for ultra-durable coatings that provides liquid-repellence, vapor imperviousness, and solid-shedding capabilities.

Wancheng Gu
Wanbo Li
Youfa Zhang
ResearchOpen Access23 Sept 2023
Nature Communications

Volume: 14, P: 1-9
Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet

A graph-based pan-genome constructed using de novo genome assemblies of ten pearl millet accessions adapted to different climates worldwide identifies structural variations and their contribution to heat tolerance in pearl millet.

Haidong Yan
Min Sun
Linkai Huang
ResearchOpen Access02 Mar 2023
Nature Genetics

Volume: 55, P: 507-518
Responses of sequential and hierarchical phenological events to warming and cooling in alpine meadows

Describing changes in the timing of life history events is critical to understanding effects of climate change. Wang et al. relocated plant communities up and down elevation gradients and found that warming lengthened the reproductive and activity phases, while cooling reduced the vegetative and reproductive phases.

Xine Li
Lili Jiang
Guojie Wang
ResearchOpen Access18 Aug 2016
Nature Communications

Volume: 7, P: 1-8
Dielectric identification method and system design of coal gangue based on frequency shift characteristics

Xinquan Wang
Meng Wu
Panpan Zhao
ResearchOpen Access13 Mar 2025
Scientific Reports

Volume: 15, P: 1-14
ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

Elevated expression of ULK1 is known to be inversely correlated with breast cancer metastasis. Here, the authors report Exo70 as a substrate of ULK1 that suppresses cancer metastasis, and show that ERK1/2 mediated phosphorylation of Exo70 leads to opposing effects on tumour cell invasion.

Liyuan Mao
Yan-yan Zhan
Tianhui Hu
ResearchOpen Access08 Jan 2020
Nature Communications

Volume: 11, P: 1-12
DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection

Yiling Yang
Ruoke Wang
Linqi Zhang
ResearchOpen Access31 Dec 2024
npj Vaccines

Volume: 9, P: 1-12
Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix

The Alx3 transcription factor, expressed in prenatal tooth development, is shown to revitalize adult progenitor cells in decellularized scaffolds, leading to enhanced parenchymal dental pulp and vascularized stroma regeneration in vivo.

Ling He
Jian Zhou
Jeremy Mao
Research21 May 2019
Nature Materials

Volume: 18, P: 627-637
Structural insights into the assembly and activation of IL-1β with its receptors

The proinflammatory cytokine IL-1β signals via a heterodimeric receptor composed of the receptor IL-1RI and the accessory protein IL-1RAcP. Wang and colleagues solve the ligand-receptor structure and explain how antagonist interactions differ.

Dongli Wang
Senyan Zhang
Xinquan Wang
Research29 Aug 2010
Nature Immunology

Volume: 11, P: 905-911
Exploiting pH-Regulated Dimer-Tetramer Transformation of Concanavalin A to Develop Colorimetric Biosensing of Bacteria

Xiahong Xu
Yuwei Yuan
Hua Yang
ResearchOpen Access03 May 2017
Scientific Reports

Volume: 7, P: 1-8
Cryo-EM structure of the exocyst complex

The structure of the fully assembled yeast exocyst complex, which mediates the tethering of secretory vesicles to the plasma membrane during exocytosis, provides new insights to hierarchical complex assembly and the mechanism of vesicle tethering.

Kunrong Mei
Yan Li
Wei Guo
Research15 Jan 2018
Nature Structural & Molecular Biology

Volume: 25, P: 139-146
Lkb1 maintains T_reg cell lineage identity

The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (T_reg) cells, and that T_reg-specific Lkb1-deficient mice develop fatal autoimmune disease.

Di Wu
Yuechen Luo
Xiaoming Feng
ResearchOpen Access16 Jun 2017
Nature Communications

Volume: 8, P: 1-14
The prognostic and therapeutic value of the tumor microenvironment and immune checkpoints in pancreatic neuroendocrine neoplasms

Zhijiang Chen
Shizhao Lin
Yu Pan
ResearchOpen Access21 Oct 2024
Scientific Reports

Volume: 14, P: 1-10
Bilateral adrenal artery embolization for the treatment of idiopathic hyperaldosteronism: A proof-of-principle single center study

Guo Ji
Changqiang Yang
Peijian Wang
Research19 Sept 2024
Hypertension Research

Volume: 48, P: 200-211
Unilateral chemical ablation of the adrenal gland lowers blood pressure and alleviates target organ damage in spontaneously hypertensive rats

Methods: Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) were subjected to unilateral adrenal ablation with injection of ethanol or a sham procedure. Blood pressure was monitored for 24 weeks. Results: Adrenal ablation significantly lowered systolic and diastolic blood pressure of SHR but not WKY from 4 to 24 weeks after the procedure. Conclusion: Unilateral debulking of the adrenal gland using ethanol ablation is a promising therapeutic strategy for treating hypertension.

Xinquan Wang
Tao Luo
Peijian Wang
Research03 Oct 2023
Hypertension Research

Volume: 46, P: 2693-2704
A controlled trial of percutaneous adrenal arterial embolization for hypertension in patients with idiopathic hyperaldosteronism

Yaqiong Zhou
Xinquan Wang
Peijian Wang
Research29 Aug 2023
Hypertension Research

Volume: 47, P: 311-321
Increased stem cells delivered using a silk gel/scaffold complex for enhanced bone regeneration

Xun Ding
Guangzheng Yang
Xinquan Jiang
ResearchOpen Access19 May 2017
Scientific Reports

Volume: 7, P: 1-10
Grassland changes and adaptive management on the Qinghai–Tibetan Plateau

Climate change and anthropogenic activities are altering grasslands on the Qinghai–Tibetan Plateau. This Review examines vegetation and soil changes, and the role of various drivers in affecting them.

Yanfen Wang
Wangwang Lv
Haishan Niu
Reviews06 Sept 2022
Nature Reviews Earth & Environment

Volume: 3, P: 668-683
Modulation recognition method of mixed signals based on cyclic spectrum projection

Weichao Yang
Ke Ren
Li Li
ResearchOpen Access05 Dec 2023
Scientific Reports

Volume: 13, P: 1-18
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

Xiaoman Li
Yongbing Pan
Xinquan Wang
ResearchOpen Access08 Sept 2022
Cell Discovery

Volume: 8, P: 1-15
Nucleotide metabolism-associated drug resistance gene NDUFA4L2 promotes colon cancer progression and 5-FU resistance

Hongxin HE
Shiyao ZHENG
Chunkang YANG
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-17
Corilagin enhances the anti-tumor activity of 5-FU by downregulating the expression of GRP 78

Simin Li
Xinquan Li
Qiang Wang
ResearchOpen Access19 Dec 2023
Scientific Reports

Volume: 13, P: 1-14
Transmembrane protein 117 knockdown protects against angiotensin-II-induced cardiac hypertrophy

Yi Yang
Xinquan Wang
Peijian Wang
ResearchOpen Access24 Jul 2023
Hypertension Research

Volume: 46, P: 2326-2339
Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study

Ruoyang Shao
Yu Zhang
Li Xuan
ResearchOpen Access14 Sept 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-11
Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity

Wen-Ting Chen
Wen-Yang Huang
Hsien-Sheng Yin
ResearchOpen Access09 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
Clinical characteristics and influencing factors of anti-PD-1/PD-L1-related severe cardiac adverse event: based on FAERS and TCGA databases

Xitong Cheng
Jierong Lin
Jing Yang
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-18
A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering

Sihan Liu
Yanxia Fu
Shigao Yang
Research22 Sept 2020
Cellular & Molecular Immunology

Volume: 18, P: 1883-1895
Use of dual genomic sequencing to screen mitochondrial diseases in pediatrics: a retrospective analysis

Teng-Hui Wu
Jing Peng
Fang He
ResearchOpen Access14 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Growth differentiation factor 15 promotes blood vessel growth by stimulating cell cycle progression in repair of critical-sized calvarial defect

Shaoyi Wang
Mengyu Li
Chi Yang
ResearchOpen Access22 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Surface thermal oxidation on titanium implants to enhance osteogenic activity and in vivo osseointegration

Guifang Wang
Jinhua Li
Xinquan Jiang
ResearchOpen Access22 Aug 2016
Scientific Reports

Volume: 6, P: 1-13
Effects of Sr-HT-Gahnite on osteogenesis and angiogenesis by adipose derived stem cells for critical-sized calvarial defect repair

Guifang Wang
Seyed-Iman Roohani-Esfahani
Xinquan Jiang
ResearchOpen Access20 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
A novel circular RNA, circMAML3, promotes tumor progression of prostate cancer by regulating miR-665/MAPK8IP2 axis

Zeng Zhenhao
Chen Ru
Wang Gongxian
ResearchOpen Access14 Dec 2023
Cell Death Discovery

Volume: 9, P: 1-15
Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development

Yongzhen Lai
Yan Guo
Weihui Chen
ResearchOpen Access13 Sept 2023
Scientific Reports

Volume: 13, P: 1-14
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

Xiao-Li Ping
Bao-Fa Sun
Yun-Gui Yang
ResearchOpen Access10 Jan 2014
Cell Research

Volume: 24, P: 177-189
Micromechanical interlocking structure at the filler/resin interface for dental composites: a review

Shuning Zhang
Xiao Wang
Xinquan Jiang
ReviewsOpen Access31 May 2023
International Journal of Oral Science

Volume: 15, P: 1-13
Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2

Shuyuan Zhang
Qingtai Liang
Xinquan Wang
CorrespondenceOpen Access12 Jan 2022
Cell Research

Volume: 32, P: 315-318
The retinoid X receptor α modulator K-80003 suppresses inflammatory and catabolic responses in a rat model of osteoarthritis

Hua Li
Xiaofan Li
Yuhang Li
ResearchOpen Access20 Aug 2021
Scientific Reports

Volume: 11, P: 1-12

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