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Showing 1–50 of 92 results

Advanced filters: Author: Xinying Li Clear advanced filters

Research on multi-algorithm and explainable AI techniques for predictive modeling of acute spinal cord injury using multimodal data

Jiaojiao Tai
Linbang Wang
Jingkun Liu
ResearchOpen Access29 May 2025
Scientific Reports

Volume: 15, P: 1-19
Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells

Liver endothelial cells respond differentially to various insults, influencing the liver’s niche and disease outcomes. Here the authors show that in response to bile acid chenodeoxycholic acid during cholestasis, endothelial Myc activation triggers P-selectin expression, promoting neutrophil infiltration and liver damage.

Peng Zhang
Xinying Li
Shiyang Li
ResearchOpen Access01 Mar 2025
Nature Communications

Volume: 16, P: 1-18
HCDT 2.0: A Highly Confident Drug-Target Database for Experimentally Validated Genes, RNAs, and Pathways

Xinying Liu
Dehua Feng
Jin Li
ResearchOpen Access25 Apr 2025
Scientific Data

Volume: 12, P: 1-7
The BRUTUS iron sensor and E3 ligase facilitates soybean root nodulation by monoubiquitination of NSP1

The authors report that iron binds to and stabilizes the iron sensor BRUTUS A (BTSa), which monoubiquitinates the pro-nodulation transcription factor NSP1a to increase its stability and transcriptional activity, thereby regulating nodulation in legumes.

Ziyin Ren
Ling Zhang
Xia Li
Research03 Feb 2025
Nature Plants

Volume: 11, P: 595-611
Adaptative two-phase thermal circulation system for complex-shaped electronic device cooling

Thermal management in compact electrical devices is challenging due to limited space and complex geometries. Here, the authors present a flexible heat pipe that conforms to arbitrary shapes without space constraints, achieving an ultra-high thermal conductivity of 11,363 W/m·K.

Wenjun Xu
Jiarong Cui
Wei Zhou
ResearchOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1-15
Alternative Z-genome biosynthesis pathway shows evolutionary progression from Archaea to phage

An alternative diaminopurine (Z) biosynthetic pathway using PurZ0 is found in bacteriophages and used for bacterial immune evasion, with higher structural and biochemical similarities to archaeal PurA than PurZ.

Yang Tong
Xinying Wu
Yan Zhang
Research12 Jun 2023
Nature Microbiology

Volume: 8, P: 1330-1338
Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

Bacterial heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are bioactive natural products that are difficult to access chemically. Here, the authors identify a family of three related HTDKP-forming cytochrome P450s and engineer key amino acid residues to produce distinct diketopiperazines frameworks.

Chenghai Sun
Zhenyao Luo
Xudong Qu
ResearchOpen Access07 Dec 2020
Nature Communications

Volume: 11, P: 1-10
S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure

Heart failure is the most prevalent complication of acute myocardial infarction. Here, the authors show that circulating S100A8/A9 is a robust predictor and potentially causal medicator for heart failure post-acute myocardial infarction, as such could serve as a promising drug target for cardioprotection.

Jie Ma
Yang Li
Yulin Li
ResearchOpen Access27 Mar 2024
Nature Communications

Volume: 15, P: 1-13
Gain-of-function PPM1D mutations attenuate ischemic stroke

Wenyan He
Yan Li
Wei-Na Jin
Research21 May 2025
Cell Death & Differentiation

P: 1-14
A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2

High-content screening of a natural diterpenoid library identified a highly potent anti-liver fibrosis lead, 12-deoxyphorbol 13-palmitate (DP), which targets apolipoprotein L2 (APOL2) and impairs APOL2–SERCA2–PERK–HES1 signaling.

Lu Gan
Qiwei Jiang
Sheng Yin
Research05 Aug 2024
Nature Chemical Biology

Volume: 21, P: 80-90
Insight-HXMT observations of jet-like corona in a black hole X-ray binary MAXI J1820+070

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

Bei You
Yuoli Tuo
Yue Zhu
ResearchOpen Access15 Feb 2021
Nature Communications

Volume: 12, P: 1-11
Characterization of a Salmonella enterica serovar Typhimurium lineage with rough colony morphology and multidrug resistance

In this study, the authors identify and characterize distinct Salmonella Typhimurium rough colony strains, likely originating from Chinese smooth colony strains around 1977 that predominantly belong to sublineage L6.5 and carry a specific csgD promoter mutation.

Ying Xiang
Kunpeng Zhu
Shaofu Qiu
ResearchOpen Access20 Jul 2024
Nature Communications

Volume: 15, P: 1-15
The acceptances and associated influences of body donation in Mainland China: a national cross-sectional study

Jian Wu
Xinyue Zhang
Yinlin Wang
ResearchOpen Access22 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
m⁶A modification-tuned sphingolipid metabolism regulates postnatal liver development in male mice

Wang et al. show that the RNA methyltransferase Mettl3 contributes to hepatic sphingolipid homeostasis by promoting RNA decay of the sphingomyelinase Smpd3 during postnatal liver development, with Mettl3 deficiency leading to ceramide accumulation and liver developmental defects.

Shiguan Wang
Shanze Chen
Detian Yuan
Research15 May 2023
Nature Metabolism

Volume: 5, P: 842-860
Standard operating procedure combined with comprehensive quality control system for multiple LC-MS platforms urinary proteomics

Urinary proteomics offers sensitive, non-invasive biomarkers, but cross-platform LC-MS data comparability requires investigation. Here, the authors evaluate 20 LC-MS platforms, developing MSCohort, a QC system with 81 metrics, and a unified SOP, paving the way for precision medicine research.

Xiang Liu
Haidan Sun
Yinghua Zhao
ResearchOpen Access26 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome

The authors provide evidence in mice and humans showing that parenteral nutrition impairs glucose and insulin homeostasis by altering the gut microbiota and its metabolites.

Peng Wang
Haifeng Sun
Xinying Wang
Research13 Feb 2023
Nature Metabolism

Volume: 5, P: 331-348
Photosensitive inhibition of the GABA system in vitro

Lei Sun
Xinying Liu
Mi Li
ResearchOpen Access21 Feb 2020
Scientific Reports

Volume: 10, P: 1-7
An integrated encyclopedia of DNA elements in the human genome

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Ian Dunham
Anshul Kundaje
Ewan Birney
ResearchOpen Access05 Sept 2012
Nature

Volume: 489, P: 57-74
Using detrital zircon to reconstruct Neoproterozoic crustal thickness variation in the northwestern margin of the Yangtze Block

Qiang Gu
Fengcun Xing
Jinchi Yi
ResearchOpen Access24 Apr 2025
Scientific Reports

Volume: 15, P: 1-18
Diagnostic and prognostic potential of cell-free RNAs in cerebrospinal fluid and plasma for brain tumors

Jinyong Huang
Jinxia Zhou
Deming Gou
ResearchOpen Access29 Apr 2025
npj Precision Oncology

Volume: 9, P: 1-12
Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

Cell free RNA is a potentially valuable resource to detect cancer, however, its low concentration in plasma can limit usefulness. Here, the authors devise a library preparation method from 100ul of plasma, and apply to multiple cancer types to detect and classify cancer patients

Jun Wang
Jinyong Huang
Deming Gou
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Early life experiences selectively mature learning and memory abilities

The mechanisms underlying the maturation of learning and memory abilities are poorly understood. Here, authors show that episodic learning produces persistent neuronal activation, BDNF-dependent increase in excitatory synapse markers (synaptophysin and PSD-95), and significant maturation of AMPA receptor synaptic responses in the hippocampus of infant rats and mice compared to juveniles and adults.

Benjamin Bessières
Alessio Travaglia
Cristina M. Alberini
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-16
CDK4/6-mediated phosphorylation of DUB3 promotes YAP1 stability and hepatocellular carcinoma progression

Lei Huang
Wenying Yuan
Yingjie Zhu
ResearchOpen Access30 Apr 2025
Cell Death Discovery

Volume: 11, P: 1-12
A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China

Shigella sonnei is a major contributor to the global burden of dysenteric diarrhoea in developed countries. In this work, authors report a S. sonnei clone which has caused numerous waterborne shigellosis outbreaks in China from 2015 to 2020.

Shaofu Qiu
Kangkang Liu
Hongbin Song
ResearchOpen Access30 Nov 2022
Nature Communications

Volume: 13, P: 1-13
Improved acid-driven inhibition of effector T cell function by a pHLIP variant-conjugated PD-L1

Hang Zheng
Mianjing Wang
Guojiang Chen
ResearchOpen Access18 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
5,200-year-old cereal grains from the eastern Altai Mountains redate the trans-Eurasian crop exchange

The spread of wheat and barley involves evolutionary and human adaptation but has been difficult to date properly. Findings from a cave site suggest a much earlier transfer of cereal grains across Eurasia.

Xinying Zhou
Jianjun Yu
Xiaoqiang Li
Research13 Feb 2020
Nature Plants

Volume: 6, P: 78-87
The B-type response regulator GmRR11d mediates systemic inhibition of symbiotic nodulation

Cytokinin is essential for regulation of nodulation. Here, the authors identified a B-type response regulator GmRR11d that governs a transcriptional program associated with nodulation and cytokinin activation essential for systemic regulation of nodulation.

Jiahuan Chen
Zhijuan Wang
Xia Li
ResearchOpen Access10 Dec 2022
Nature Communications

Volume: 13, P: 1-17
A dataset of multi-level street-block divisions of 985 cities worldwide

Jintong Tang
Liyan Xu
Yu Liu
ResearchOpen Access19 Mar 2025
Scientific Data

Volume: 12, P: 1-15
Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation

Ruijun Han
Xinying Wang
John W. Osborn
ResearchOpen Access05 Aug 2015
Scientific Reports

Volume: 5, P: 1-11
Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression

The effect of β-glucans and their receptor Dectin-1 in tumor development remains controversial. Here the authors show that Dectin-1 signaling promotes the development of colorectal cancer (CRC) by inducing prostaglandin E2 production in myeloid-derived suppressor cells and by suppressing IL-22BP expression, suggesting dectin-1 blockade as a potential therapeutic target for CRC.

Ce Tang
Haiyang Sun
Yoichiro Iwakura
ResearchOpen Access17 Mar 2023
Nature Communications

Volume: 14, P: 1-21
DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans

Transposons are accepted as evolutionary catalysts but how they do so remains less clear. Analyzing 100 animal genomes finds that terminal inverted repeat-type transposable elements catalyze new gene structures and new genes in animals via both transposition-independent and -dependent mechanisms.

Shengjun Tan
Huijing Ma
Yong E. Zhang
ResearchOpen Access13 Jul 2021
Nature Communications

Volume: 12, P: 1-14
Near-complete genome and infection transcriptomes of the maize leaf and sheath spot pathogen Epicoccum sorghinum

Vijai Bhadauria
Guangjun Li
Pedro Laborda
ResearchOpen Access13 Feb 2025
Scientific Data

Volume: 12, P: 1-8
RACK1 antagonizes TNF-α-induced cell death by promoting p38 activation

Qingyang Wang
Silei Zhou
Jiyan Zhang
ResearchOpen Access18 Sept 2015
Scientific Reports

Volume: 5, P: 1-9
Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients

Zheng Li
Qiuji Wu
Yahua Zhong
ResearchOpen Access10 Jun 2021
Scientific Reports

Volume: 11, P: 1-8
Disulfidptosis links the pathophysiology of ulcerative colitis and immune infiltration in colon adenocarcinoma

Chenhao Jiang
Teng Yue
Qianqian Li
ResearchOpen Access13 Feb 2025
Scientific Reports

Volume: 15, P: 1-17
Nanosecond laser coloration on stainless steel surface

Yan Lu
Xinying Shi
Wei Cao
ResearchOpen Access02 Aug 2017
Scientific Reports

Volume: 7, P: 1-8
Circulation of HAdV-41 with diverse genome types and recombination in acute gastroenteritis among children in Shanghai

Peng Li
Lang Yang
Hongbin Song
ResearchOpen Access14 Jun 2017
Scientific Reports

Volume: 7, P: 1-9
Oldest Directly Dated Remains of Sheep in China

John Dodson
Eoin Dodson
Sun Nan
ResearchOpen Access24 Nov 2014
Scientific Reports

Volume: 4, P: 1-4
Strontium isotope evidence for a highly mobile population on the Pamir Plateau 2500 years ago

Xueye Wang
Zihua Tang
Xinying Zhou
ResearchOpen Access20 Oct 2016
Scientific Reports

Volume: 6, P: 1-7
TMEM232 is required for the formation of sperm flagellum and male fertility in mice

Xinying Cai
Hui Zhang
Fengsong Wang
ResearchOpen Access08 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-18
Improved YOLOv8n based helmet wearing inspection method

Xinying Chen
Zhisheng Jiao
Yuefan Liu
ResearchOpen Access14 Jan 2025
Scientific Reports

Volume: 15, P: 1-16
CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions

Lei Huang
Yalei Wen
Tongzheng Liu
ResearchOpen Access18 Jan 2025
Cell Death & Disease

Volume: 16, P: 1-14
Toward sustainability: mechanism between work–family balance and fertility intention with decent work as the mediating role

Yuqing Geng
Xinying Jiang
Jianyi Li
ResearchOpen Access27 Sept 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-12
Integrating deformable CNN and attention mechanism into multi-scale graph neural network for few-shot image classification

Yongmin Liu
Fengjiao Xiao
Lei Wu
ResearchOpen Access08 Jan 2025
Scientific Reports

Volume: 15, P: 1-15
BRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK signaling

Shunkang Wu
Yuelin Deng
Hsiang-Ying Lee
ResearchOpen Access02 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-15
Integrative analysis of 5-methylcytosine associated signature in papillary thyroid cancer

Ying Ding
Xinying Li
Lei Cai
ResearchOpen Access05 Feb 2025
Scientific Reports

Volume: 15, P: 1-15
Low-carbon transition and energy poverty: quasi-natural experiment evidence from China’s low-carbon city pilot policy

Yiming Xiao
Zhijun Feng
Shangrui Wang
ResearchOpen Access09 Jan 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-18
Frequent KIT Mutations in Human Gastrointestinal Stromal Tumors

Zhi Xu
Xinying Huo
Jinfei Chen
ResearchOpen Access01 Aug 2014
Scientific Reports

Volume: 4, P: 1-9
Research on stock prediction based on CED-PSO-StockNet time series model

Xinying Chen
Fengjiao Yang
Weiguo Yi
ResearchOpen Access10 Nov 2024
Scientific Reports

Volume: 14, P: 1-28
Sodium oligomannate disrupts the adherence of Rib^high bacteria to gut epithelia to block SAA-triggered Th1 inflammation in 5XFAD transgenic mice

Xinyi Wang
Zuoquan Xie
Meiyu Geng
ResearchOpen Access19 Nov 2024
Cell Discovery

Volume: 10, P: 1-19

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