Search

Neural circuit mechanisms that regulate the panic-like defensive state are not fully understood. Using a robot-based experimental paradigm, the authors identify Cbln2-expressing (Cbln2+) neurons in the mouse posterior hypothalamic nucleus (PHN) as a key neuronal population essential for the induction of panic-like defensive state.

Combining antibody drug conjugates (ADCs) and tyrosine kinase inhibitors (TKIs) targeting HER2 has been shown to improve efficacy in patients with advanced HER2+ breast cancer. Here, the authors report a randomised phase 2b trial comparing neoadjuvant ARX788 (HER2 ADC) plus pyrotinib (HER1, HER2 and HER4 TKI) against neoadjuvant standard of care (docetaxel, carboplatin, trastuzumab, and pertuzumab) for the treatment of HER2+ breast cancer.

Li-In alloys are widely used as reference materials in the research field of solid-state lithium-based batteries. Here, the authors report and discuss the instability of Li-In electrodes towards sulfide solid electrolytes in all-solid-state batteries.

Authors use a high-entropy engineering approach to produce fully amorphous BiTO films by exfoliation and annealing, creating crystalline regions, leading to flexible ceramics with dielectric properties.

This work introduces DeepTernary, a deep learning method for rapid and accurate prediction of PROTAC and molecular glue-induced ternary complex structures, achieving state-of-the-art results by learning from a curated dataset, TernaryDB.

Florets of indica rice open earlier than japonica rice, hindering utilization of the cross subspecies heterosis. Here, the authors show that an OsMYB8-OsJAR1 module regulates diurnal floret opening time divergences between the two subspecies.

Porous graphene integrated into graphene oxide membranes yields smart molecular sieves that switch separation based on the solvent. This allows for graded separations of different-sized molecules.

The authors find that Ag-rich nanoprecipitates with sizes up to tens of nanometers can be formed in metallic Ag/Ag₂Se composite flexible films after spark plasma sintering. Moreover, Ag-rich nanoprecipitates play a positive role in increasing the carrier concentration, enhancing the density-of-states effective mass, and mitigating carrier scattering.

A new asymmetric non-fullerene acceptor, P2EH-1V, is designed and synthesized for constructing devices demonstrating record-high efficiencies of 26.7% (certified at 26.4%) over an aperture area greater than 1 cm² in perovskite–organic tandem solar cells.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Sodium layered oxide-based cathodes of sodium-ion batteries commonly suffer from structural degradation. Here, authors propose entropy regulation with zero Li/Co usage to suppress lattice strain, enhancing structural stability and improving the electrochemical performance.

The mechanism of HIV-1 latency reversal remains unclear. The authors suggest that PRMT3 drives the reversal by enhancing chromatin accessibility to form a transcriptional hub containing TEAD4 and P-TEFb at the viral promoter.

Neuromorphic motion devices improve dynamic tracking but are generally limited to near-infrared. Here, the authors use PdSe₂/pentacene heterostructures to develop a neuromorphic transistor for efficient mid-infrared real-time motion trajectory memorization and flame direction classification.

All-solid-state electrolytes for lithium batteries generally suffer from low ionic conductivity. Here, authors manipulate the lattice of antiperovskite-type Li₂OHCl by potassium ion substitution, which alters the lattice structure and improves the lithium ion transport properties.

Solid-state sodium batteries using halide electrolytes face ionic transport limitations and (electro)chemical instability. Here, authors design fluorinated amorphous sodium halides via vacancy-carrier optimization and fluorination-driven amorphization, enhancing discharge capacity and cycle stability in Na₃V₂(PO₄)₃-based all-solid-state batteries.

Cs₃LnCl₆ (Ln = Ce–Lu) microcrystals were prepared via recrystallization method at room temperature. Cs₃TbCl₆ microcrystals exhibit high light yield and excellent imaging ability under X-ray irradiation.

Artificial intelligence, especially large language models, can help urban planning to tackle key challenges. This Perspective explores potential applications and challenges for planners and cities.

Hexagonal boron nitride (h-BN) encapsulation is important to improve the performance of graphene devices, but it is normally restricted by exfoliation and transfer methods. Here, the authors report the conformal h-BN encapsulation for the hierarchical configuration of large-scale graphene-skinned glass fiber fabrics via chemical vapor deposition, leading to improved electrical and thermal stability.

Meta-learning-empowered reflective lattice light-sheet virtual structured illumination microscopy (Meta-rLLS-VSIM) offers near-isotropic resolution for fast and versatile super-resolution imaging of subcellular dynamics

A new deep learning-based global medium-range weather forecasting model outperforms existing machine learning models and the European Centre for Medium-Range Weather Forecasts model, producing accurate global weather forecasts beyond ten days.

This study identifies lineage-specific XEG1/XLP1 gene pair in the genus Phytophthora, revealing that selective pressure on these genes drives functional differentiation. This selection is closely linked to the host range and adaptability of Phytophthora species.

Focal cortical dysplasia type II causes epileptic seizures and is associated with various types of neuronal abnormalities. This study uses patient tissue transcriptomics and animal models to reveal that vascular malformations are a key part of the pathology by creating ischemic-hypoxic microenvironments.

The between-hemisphere functional divergence deepens our understanding of hemispheric lateralization as a fundamental organizational principle of the human brain, providing empirical evidence for its role in supporting fluid intelligence.

Stress shielding, a common cause of orthopedic implant failure, reduces the activity of intracellular mechanotransduction molecules, which are also regulated by nociceptors. Here, Wang et al. develop a small, implantable, wirelessly rechargeable device for optogenetic regulation of mechanosensitive nociceptors to investigate and improve implant osseointegration.

Magnetized and biohybrid blood hydrogel fibres can be used for magnetically controlled targeted drug delivery into tumours with real-time tracking through X-ray fluoroscopy, as shown for minipigs with intracranial tumours.

Type 1 diabetes (T1D) manifests as hyperglycemia, with spontaneous remission occasionally observed, but the underneath mechanisms are unclear. Here the authors analyses patients at different stages to find two populations of immune cells correlating with disease progression or remission, while results from mouse diabetes models validate these observations.

Based on an immunogenicity screen of monkeypox virus (MPXV) surface proteins, the authors develop an mRNA vaccine with 12 antigens, which they combine with T cell epitope-rich regions to achieve protection through coordinated activation of humoral and cellular immune responses.

Battery recycling is essential to the sustainability of electric vehicles. Here the authors show processes that could regenerate spent cathode materials for a second life in lithium-ion and post-lithium-ion batteries.

Lu and colleagues show that signaling through the lactate receptor HCAR1 in colorectal tumor cells promotes the recruitment of immunosuppressive CCR2⁺ PMN-MDSCs and that inhibition of HCAR1 by reserpine augments the CD8⁺ T cell-mediated antitumor immune response.

The authors demonstrate a chemopiezoelectric effect in which the displacive migration of oxygen vacancies driven by an electric field induces a large strain in the surface layer of thin (K,Na)NbO₃ ceramics. They achieve an electrostrain of 1.9% under a field of −3 kV mm⁻¹, with thermal stability up to 200 °C.

Amines are common targets in synthetic chemistry as they often display biological activity. Here, the authors report a one-pot aminobenzylation of aldehydes with readily available toluenes in presence of a sodium amide derivative and a cesium salt additive generating an array of valuable 1,2-diarylethylamine compounds.

Fabric-retentive dolostones preserve the lithium isotope composition of the seawater in which they formed and could provide a high-resolution record to complement or extend foraminiferal proxy records, as indicated by isotopic analyses of Neogene dolostones from the South China Sea.

The discovery of the resistosome was a milestone in plant immunity. Here, Zhong et al. identify a kinase that phosphorylates the NLR, and reveal how this kinase regulates resistosome assembly to fine-tune immune responses.

This study introduces a reconfigurable MoS2-based neuromorphic hardware that integrates synaptic, heterosynaptic, and somatic functionalities. It adapts to diverse tasks like medical image enhancement and smart perception, advancing flexible, general-purpose computing solutions.

The quality of covalent organic frameworks is often compromised by structural damages induced during their activation procedure which influences their subsequent applications. Here, the authors describe a self-sacrificing guest strategy to synthesize high-quality two-dimensional COFs by incorporating salt guests within the pores of the COF structure.

Current brain-targeted delivery strategies using orthosteric sites of receptors is highly susceptible to cross-reactions limiting efficiency. Here, the authors report on the allosteric targeting of receptors to avoid this and demonstrate application in drug delivery across the blood brain barrier.

Transient R-loops form around DSBs must be timely removed for HR repair. Here, the authors show that SART3 promotes DDX1 helicase binding to DSBs for optimal DNA-RNA hybrid removal, and enhances USP15-BARD1 association for efficient DNA end resection.

Graphene-based photodetectors have many advantages for applications. Here, the authors demonstrate a high-speed optical coherent receiver for optical communications based on graphene-on-plasmonic slot waveguide photodetectors.