The learning of novel motor skills through repetitive practice is associated with enhanced synaptic efficacy in the motor cortex. However, how motor learning affects neuronal circuitry at the level of individual synapses and how long-lasting memory is structurally encoded in the intact brain remain unknown. Synaptic connections in the living mouse brain are now shown to respond to motor-skill learning and permanently rewire; this could be the foundation of durable motor memory.
- Tonghui Xu
- Xinzhu Yu
- Yi Zuo
