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Protonic ceramic electrochemical cells (PCECs) interconvert hydrogen and electricity and therefore have potential as long-duration energy storage systems, but the durability of these devices under industrially relevant conditions is limited. Here the authors report a PCEC that maintains low degradation rates throughout exceptionally long-term durability tests.

Microsatellite-instability-high gastric cancers typically respond to immune checkpoint inhibitors, but only a small proportion of patients in the microsatellite-stable group responds. Here authors stratify these patients via a semi-supervised learning approach using multi-omics input data and functionally validate T-bet+ CD8 + T cells as crucial factor in the immunotherapy response.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

High energy density materials are of interest, but density is the limiting factor for many organic compounds. Here the authors show the formation of a high density energetic compound from a two-step reaction between commercially available compounds that exhibit good heat thermal stability and detonation properties.

The search for environmentally friendly, lead-free primary explosives continues to be important for both military and civil applications. Here the authors synthesize an organic fused-ring initiating substance that possesses many of the attributes necessary for commercial application.

Studying tumour heterogeneity and tumour evolution remains a challenging task. Here, the authors propose a supercontinuum-tailoring two-photon microscope to enable the imaging of multiple fluorophores with a single light beam. They use this tool to monitor the dynamics of heterogeneous tumour evolution.

Predicting TCR–antigen–human leucocyte antigen binding opens the door to neoantigen identification. In this study, a physics-inspired sliding transformer (PISTE) system is used to guide the positioning of amino acid residues along the gradient field of their interactions, boosting binding prediction accuracy.

Ductal lavage represents a treatment option for idiopathic granulomatous mastitis. Here, the authors report the results of a randomized clinical trial, indicating that ductal lavage followed by observation is non-inferior to oral corticosteroids

Cytotoxic chemotherapy remains the standard treatment for triple negative breast cancer (TNBC), an aggressive subtype of breast cancer associated with poor prognosis. Here the authors report the results of a phase 1b trial of the liposomal irinotecan HE072 in patients with metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy.

Higher-order topological phenomenologies are usually observed separately, with each system giving rise to a specific type of topological insulator. Here, the authors realise a nonsymmorphic acoustic metacrystal where the first and the second band gap host dipole and quadrupole topology respectively.

By tuning the geometry of a two-dimensional sonic crystal, its one-dimensional helical edge states become gapped and zero-dimensional topological corner states emerge. The band topology is thus manifested in a hierarchy of dimensions.

Intelligent artificial tactile system for neurorobotics remains challenging. Here, Chen et al. developed an artificial organic afferent nerve to implement slip recognition and prevention actions by learning the real-time spatial information of directional touch.

CdS nanostructures can enable memory based photodetection by charge-storage accumulative effect. Here, the authors report CdS nanoribbons-based memory phototransistors with high responsivity of 3.8 × 10⁹ A/W and detectivity of 7.7 × 10²² Jones that can detect weak light of 6 nW/cm².

The domestication of cattle took place during the early Holocene, independently in the Near East and in southern Asia. Here, Zhang et al.provide evidence for management of taurine cattle in northern China, an area not previously considered as an independent domestication centre.

Halide perovskite/2D transition metal dichalcogenides (TMD) heterostructures hold promise for photonic/optoelectronic applications, but their bottom-up growth remains challenging. Here, the authors report a van der Waals heteroepitaxy strategy to synthesize various halide perovskite/TMD heterostructures with enhanced lasing performance.

Though metasurface-based 3D colour routers are attractive for next-generation colour imaging systems, their complex fabrication and poor performance remain a bottleneck. Here, the authors use the inverse-design method to realize high performance metasurface-based Bayer-type colour routers.

Measuring fitness effects of mutations in the same gene expressed at two levels, the authors show expression dependency of fitness effects in at least 42% of all single-nucleotide mutations, probably driven by avoidance of stochastic molecular errors.

Structurally coloured composite films are flexible optical materials with potential in a range of applications, but their production is impacted by long time-frames and limited materials. Here, the authors report a method for the production of large scale films by shearing supramolecular composites.

The relationship of mycorrhizal associations with latitudinal gradients in tree beta-diversity is unexplored. Using a global dataset approach, this study examines how trees with arbuscular mycorrhizal and ectomycorrhizal associations contribute to latitudinal beta-diversity patterns and the environmental controls of these patterns.

Here, the authors report the experimental discovery of such a dimensional hierarchy of the topologically-protected 2D surface states, 1D hinge states and 0D corner states in a single 3D acoustic system by using higher-order topological sonic crystals.

Metformin decreases the levels of Bacteroides fragilis while increasing the bile acid GUDCA to antagonize intestinal FXR and improves the metabolic health of humans and mice.

The direct linear dichroism photodetection without external optics is crucial for applications. Here, Jie et al. exploit the anisotropic charge trapping in organic phototransistors to achieve the dichroic ratio of 10⁴ and to demonstrate a polarizer-free celestial compass for bio-inspired navigation.

While carbon-introducing difunctionalization of C-C double bonds is well established, the analogous difunctionalization for introducing germanium group and other functionalities remains elusive. Here, the authors describe a nickel-catalyzed germylative alkylation of activated olefins with easily accessible primary, secondary and tertiary alkyl bromides and chlorogermanes as the electrophiles to form C-Ge and C-Calkyl bonds simultaneously.

In barley, a MADS transcription factor regulates inflorescence morphogenesis in response to warm temperature. MADS1 maintains unbranched spike morphology through repression of cell division in the spike meristem. A loss-of-function mutant forms branch-like spikes.

Varying monsoon extent and intensity since the expansive megamonsoon on the Pangaea supercontinent was controlled by the position and fragmentation of continental land masses, according to climate simulations and atmospheric energetic analyses.

Application of adenine base editors (ABE) has been precluded by low activity. Here the authors show the generation of a human cell based ABE directional screening system and identification of ABE variant (NG-ABEmax-KR) exhibiting a significant increase in activity for human and mouse genome manipulation.

Global reduction of m⁶A leads to mRNA stabilization in ALS/FTD caused by C9ORF72 repeat expansion. m⁶A also regulates repeat RNA decay. Elevating m⁶A reduces RNA and dipeptide repeats, restores mRNA homeostasis and improves patient neuron survival.

Triple-negative breast cancer (TNBC) is one of the most aggressive and difficult to treat types of breast cancer. Here, a phase 2 clinical trial in TNBC patients reveals that the addition of lobaplatin to docetaxel and epirubicin regime improves pCR and ORR rates with tolerable side-effects.

An organic phototransistor with two complementary bulk heterojunctions exhibits light-intensity-dependent adaptation behaviour that mimics the behaviour of the human visual system.

Zi-Jiang Chen and colleagues report a genome-wide association analysis for polycystic ovary syndrome (PCOS) in Han Chinese. They identify eight new susceptibility loci for PCOS in this population.

Diminished m6A levels contribute to recurrent implantation failure. Mechanistic studies indicate that the Mettl3/Eed/Ythdc1 axis affects endometrial function by modulating histone modification and chromatin accessibility.