Search

Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

Fan et al. show that cTAGE5 is essential for adipogenesis and adipose tissue development. Mechanistically, cTAGE5 promotes pro-insulin receptor processing, which mediates actin cytoskeleton remodeling and lipolysis during the adipocyte differentiation.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

A method for acetylome profiling requiring a low quantity of hematopoietic stem cells (HSCs) was developed, revealing a significant reduction in H4K77ac in aged HSCs, associated with decreased lymphocyte differentiation potential.

Pei et al. overcome desorption of passivating molecules under photothermal stress in wide-bandgap perovskites and achieve perovskite/Cu(In,Ga)Se₂ tandem solar cells with a certified efficiency of 27.35%.

Ultrafast electron sources are essential for time-resolved electron microscopy techniques, but they usually suffer from limited stability and short lifetimes. Here, the authors report the fabrication of ultrafast hot-electron sources consisting of graphene films integrated on a single-mode optical fibre, showing enhanced stability and longevity.

This study reveals an important formation pathway of organic nitrates in ambient aerosols through the multiphase reactions of organic peroxides and nitrite, particularly in polluted urban areas.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

The neurotransmitter serotonin regulates cancer through receptor-signaling activation, but also epigenetics mechanisms by serotonylation. Here, the authors show that histone serotonylation promotes pancreatic cancer progression by upregulating stearoyl-CoA desaturase (SCD), which remodels lipid metabolism, suggesting a potential target for therapy.

Deubiquitinating enzymes play an essential role in myocardial hypertrophy. Here, the authors show the beneficial effects of a cardiomyocyte-derived deubiquitinating enzyme, USP13, in hypertrophic cardiomyocytes and identify a cardiomyocyte-specific USP13-STAT1 axis in regulating cardiac hypertrophy.

High-performance THz electromagnetic shielding is demonstrated using 2D β₁₂-borophene nanosheets embedded in a polymer matrix. At a low loading of 0.1 wt.%, the composite has excellent shielding effectiveness and good mechanical properties.

NiFe-based hydroxides are well-known for alkaline water oxidation but face efficiency issues due to unclear Fe dynamics. Here, the authors report that surface Fe dynamics are affected by Fe diffusion on the counter electrode and have developed a zinc-templated precursor to stabilize active Fe sites.

A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.

The authors report an ultra-broadband ptychography method, suitable for dispersive samples, by exploiting structured illumination and a novel joint deconvolution algorithm.

Traditional theory favors positively charged membranes for Li+ /Mg2+ separation, but practical use prefers negatively charged ones. The authors uncover a counter-ion competition mechanism in negatively charged nanofiltration membranes, achieving high Mg2+ rejection and exceptional Li+ permeability.

LepR⁺ cells senescence is a driver of aging-induced bone marrow homeostasis collapse. Here, Li et al. report a LepR⁺ cell-targeting nitric oxide (NO) nanopump for rejuvenation of senescent LepR⁺ cells via activation of glycolysis signaling to reestablish homeostasis of the aged bone marrow.

In situ methods for water quality monitoring is crucial for global water use and management, though many conventional sensors have slow response time and are non-recyclable. Here, the authors report a recyclable amphiphobic dielectric material for fast monitoring of water pollutants.

Neural circuit mechanisms underlying feeding behavior regulation are not fully understood. Here authors provide quantitative mapping of the brain-wide input and output configuration of tuberal nucleus somatostatin neurons, a key player of feeding regulation, in mouse brain for a deeper understanding of the feeding regulation network.

Authors use a high-entropy engineering approach to produce fully amorphous BiTO films by exfoliation and annealing, creating crystalline regions, leading to flexible ceramics with dielectric properties.

China contributed about half of the global carbon tetrachloride (CCl₄) emissions during 2011–2021, according to long-term atmospheric observations from China.

The authors show that NAT10 is upregulated with T cell antigen receptor signaling and that T cell-specific NAT10 deficiency results in diminished numbers of naive T cells, translating to an inability to mount a significant antiviral T cell response.

White-light emission from materials and devices usually occurs omni-directional through space. Here, the authors show that sintering carbon dots with TiO₂ forms a microlens-shape surface that enables directional emission with 1/60 solid angle.

Acetylation is a posttranscriptional modification widely distributed across RNA types. Here, the authors uncover the role of tRNA ac⁴C12 for translational efficiency and tRNA quality control in both normal and heat stress conditions in mammalian cells.

A gold catalyst supported on intergrown titanosilicate zeolites enhances propene oxide production by activating oxygen-transfer intermediates more efficiently at Ti interface sites.

It is important to understand cellular uptake of nanoparticles, but the effects of cell cycle and autophagy are underexplored. Here, the authors construct a multi-functional, multi-dimensional platform, and use this to characterise the effects of cell cycle- and autophagy-associated cellular accumulation of clinically used lipid-based nanoparticles.

Neural networks fundamentally dictate function. Here, the authors show thirteen uniquely connected neuron populations within the anterior thalamic nuclei, suggesting multiple parallel subnetworks support its emotional and cognitive functions.

Sequence-based algorithms to identify T cell antigens often miss targets that are activating the immune response. Here authors show that a computational method they developed, which uses atomic level features as input, can identify antigens that trigger cytokine release in cognate T cells.

Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese cohorts (GHABS and Huashan) and the North American ADNI cohort.

Most studies on the potential of meat alternatives to mitigate environmental pollution look at greenhouse gas emissions, but groundwater quality remains understudied. Using a groundwater nitrate pollution risk assessment model, this study estimates the benefits of a shift away from beef, poultry and pork in the USA over 1985–2020.

Chain-elongating oxidations enable molecular complexity to be carefully and logically assembled. Herein, the authors report a photoexcited nitroarene-enabled regioselective chain-elongated oxidation of alkenes via tandem oxidative cleavage and dipolar cycloaddition, providing a broad range of synthetically-useful isoxazolidines from readily available enol ethers or styrene and derivatives.

Enantioselective synthesis of chiral compounds is of high interest due to their importance in organic chemistry, medicinal chemistry, life science, and materials, though it is challenging to achieve enantioselectivity for allyl-allyl couplings. Here the authors report a Cu/Pd catalyzed coupling affording a series of optically active 1,5-alkadienes with either tertiary or quaternary carbon stereocenters.

Zhang, Peng, and colleagues benchmark metabolic RNA labelling chemistries for time-resolved single-cell RNA sequencing, improving in vivo detection of newly synthesized RNA during zebrafish embryogenesis.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Human airway contains physiologically relevant yet rare cells, but their scarcity prevents thorough profiling and differentiation studies. Here the authors use single cell RNA sequencing to identify rare ionocytes and tuft cells, as well as a potential progenitor population with cytokine-guided differentiation into either the ionocytes or tuft cell lineage.

The generation and maintenance of peri-implant fibrotic tissue requires skeletal cells expressing the leptin receptor and can be prevented and reversed via the functional inhibition of these cells.

Kidney stone disease is increasing worldwide. Cao et al. perform a cross-ancestry GWAS meta-analysis of the condition, identifying risk loci and potential causal variants, and construct a cross-population polygenic risk score.

An aromatic metallo-annulene, comprising a 15-carbon macrocycle enclosing an osmium complex, with the metal residing within the plane of the macrocycle is reported.

Neural mechanisms underlying strengthening of escape behaviors are not fully understood. Here authors show that mPFC (medial prefrontal cortex)/VTg (ventral tegmental nucleus of gudden) to cholecystokinin expressing neurons in PMd (dorsal premammillary nucleus) neural pathway controls the threat memory-driven strengthening of escape. Furthermore, authors demonstrate a heterosynaptic role of eCB (endocannabinoid) signaling as the underlying molecular mechanism.

Zhu and colleagues show that a subpopulation of spleen-derived fibroblasts secrete Gremlin 1, which suppresses chronic myeloid leukemia progression by inducing leukemia stem cell apoptosis through the BMP signaling pathway.

Sun et al. identify a role for PABPC1 in selectively regulating the translation of leukaemogenic mRNAs to promote blast crisis transition, which may be targeted to overcome resistance to TKI treatment in chronic myeloid leukaemia.