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Characterization of somatic structural variations in 528 Chinese individuals with Esophageal squamous cell carcinoma

The biological and clinical implications of high genome instability in esophageal squamous cell carcinoma (ESCC) remain to be explored. Here, the authors analyse 528 whole genomes and investigate the landscape and molecular mechanisms underlying structural variations in ESCC patients.

Heyang Cui
Yong Zhou
Qimin Zhan
ResearchOpen Access22 Oct 2022
Nature Communications

Volume: 13, P: 1-18
Identification of genomic alterations in oesophageal squamous cell cancer

Using whole-genome and whole-exome sequencing, this study identifies eight significantly mutated genes in oesophageal squamous cell cancer, including two genes, ADAM29 and FAM135B, not previously associated with this cancer type.

Yongmei Song
Lin Li
Qimin Zhan
Research16 Mar 2014
Nature

Volume: 509, P: 91-95
Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease

Xuejun Zhang, Jun Wang, Liangdan Sun, Lennart Hammarström and colleagues sequence the MHC region in 20,635 Han Chinese individuals. Their Han-MHC database allows identification of new susceptibility loci for psoriasis and could serve as a tool for investigating the role of the MHC region in other complex diseases.

Fusheng Zhou
Hongzhi Cao
Xuejun Zhang
Research23 May 2016
Nature Genetics

Volume: 48, P: 740-746
Uncovering the genetic lesions underlying the most severe form of Hirschsprung disease by whole-genome sequencing

Clara SM Tang
Xuehan Zhuang
Maria-Mercè Garcia-Barcelo
Research26 Feb 2018
European Journal of Human Genetics

Volume: 26, P: 818-826
IGH repertoire analysis at scale: deciphering the complexity of B cell infiltration and migration in esophageal squamous cell carcinoma

Longlong Wang
Yong Zhou
Weimin Zhang
Research20 Nov 2023
Cancer Gene Therapy

Volume: 31, P: 131-147
Comprehensive analysis of recessive carrier status using exome and genome sequencing data in 1543 Southern Chinese

Jeffrey Fong Ting Chau
Mullin Ho Chung Yu
Clara Sze Man Tang
ResearchOpen Access21 Mar 2022
npj Genomic Medicine

Volume: 7, P: 1-9
Transcriptomic analysis of interstock-induced dwarfism in Sweet Persimmon (Diospyros kaki Thunb.)

Yanying Shen
Weibing Zhuang
Shenchun Qu
ResearchOpen Access01 May 2019
Horticulture Research

Volume: 6, P: 1-17

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Characterization of somatic structural variations in 528 Chinese individuals with Esophageal squamous cell carcinoma

Identification of genomic alterations in oesophageal squamous cell cancer

Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease

Uncovering the genetic lesions underlying the most severe form of Hirschsprung disease by whole-genome sequencing

IGH repertoire analysis at scale: deciphering the complexity of B cell infiltration and migration in esophageal squamous cell carcinoma

Comprehensive analysis of recessive carrier status using exome and genome sequencing data in 1543 Southern Chinese

Transcriptomic analysis of interstock-induced dwarfism in Sweet Persimmon (Diospyros kaki Thunb.)

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