Nature Search

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress

Rhine et al. find that neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress and reduced resiliency.

Kevin Rhine
Rachel Li
Gene W. Yeo
ResearchOpen Access02 Jun 2025
Nature Neuroscience

Volume: 28, P: 1174-1184
Author Correction: The reference genome of Miscanthus floridulus illuminates the evolution of Saccharinae

Guobin Zhang
Chunxia Ge
Cuixia Chen
Amendments and CorrectionsOpen Access28 Jun 2021
Nature Plants

Volume: 7, P: 990
Publisher Correction: The reference genome of Miscanthus floridulus illuminates the evolution of Saccharinae

Guobin Zhang
Chunxia Ge
Cuixia Chen
Amendments and CorrectionsOpen Access28 Jun 2021
Nature Plants

Volume: 7, P: 991
The prognostic value and biological significance of MRI CE-T1-based radiomics models in CNS5-identified GBM: a multi-center study

Mingwei Zhang
Xiaoxia Li
Jinsheng Hong
ResearchOpen Access11 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Specificity of TGF-β1 signal designated by LRRC33 and integrin α_Vβ₈

Microenvironment localization and activation of L-TGF-β1 determine its specific function. Here, the authors elucidated the underlying mechanisms of specific presentation of L-TGF-β1 on the surface of myeloid lineage cells designated by LRRC33, and its activation by integrin αVβ8.

Zelin Duan
Xuezhen Lin
Zhe Zhang
ResearchOpen Access25 Aug 2022
Nature Communications

Volume: 13, P: 1-13
Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis

Allergic asthma is episodic and associated with seasonal changes which may have links with UV exposure levels. Here the authors propose a link between UVB exposure and ILC2 function through α-MSH released from the pituitary gland which accumulates in the serum and alters ILC2 function through the MC5R receptor.

Yuying Huang
Lin Zhu
Bing Sun
ResearchOpen Access12 Sept 2023
Nature Communications

Volume: 14, P: 1-16
Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease

A meta-analysis of exome-wide association studies for blood lipid levels in East Asian populations identifies a novel coding variant. Exome array data from the Global Lipids Genetics Consortium were integrated and led to the discovery of novel and population-specific variants associated with cholesterol and triglycerides.

Xiangfeng Lu
Gina M Peloso
Cristen J Willer
Research30 Oct 2017
Nature Genetics

Volume: 49, P: 1722-1730
Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion

Sun and colleagues describe that the secretion of interleukin-33 is dependent on a p40 N-terminal fragment of gasdermin D, whose generation is independent of inflammatory caspase-1 and caspase-11.

Wen Chen
Shuangfeng Chen
Bing Sun
Research06 Jul 2022
Nature Immunology

Volume: 23, P: 1021-1030
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in hepatic steatosis worsening and HCC development via metabolic and immune reprogramming.

Hanyong Sun
Weiqin Yang
Alfred S. L. Cheng
ResearchOpen Access06 Dec 2018
Nature Communications

Volume: 9, P: 1-16
The reference genome of Miscanthus floridulus illuminates the evolution of Saccharinae

Miscanthus is widely used as a feedstock for cellulosic biofuel production. Genome sequencing shows that M. floridulus is most distantly related to other Miscanthus species and is more genetically diverse.

Guobin Zhang
Chunxia Ge
Cuixia Chen
ResearchOpen Access06 May 2021
Nature Plants

Volume: 7, P: 608-618
HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation

Zhishuo Wang
Chenghua Yan
Bing Sun
Research24 Feb 2023
Cellular & Molecular Immunology

Volume: 20, P: 404-418
The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation

Wangpeng Gu
Jia Zhang
Bing Sun
ResearchOpen Access01 Aug 2023
Cell Discovery

Volume: 9, P: 1-18
CISD3 is a prognostic biomarker and therapeutic target in pan-cancer

Jie Li
Han Yang
Ke Wang
ResearchOpen Access08 Oct 2024
Scientific Reports

Volume: 14, P: 1-17
Sex-dependent effects of microcystin-LR on hypothalamic-pituitary-gonad axis and gametogenesis of adult zebrafish

Wanjing Liu
Chuanyue Chen
Xuezhen Zhang
ResearchOpen Access10 Mar 2016
Scientific Reports

Volume: 6, P: 1-12
A nomogram to predict mortality in patients with severe fever with thrombocytopenia syndrome

Kun Fang
Xuezhen Song
Jinshuang Bo
ResearchOpen Access09 May 2024
Scientific Reports

Volume: 14, P: 1-10
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver

Wenshu Tang
Jingying Zhou
Alfred S. L. Cheng
Research20 May 2022
Cellular & Molecular Immunology

Volume: 19, P: 834-847
TMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression

Zhiqian Wang
Peng Zhao
Xuezhen Ma
ResearchOpen Access25 Apr 2024
Cell Death & Disease

Volume: 15, P: 1-12
TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity

Qiaoshi Lian
Shanshan Yan
Bing Sun
Research24 Feb 2020
Cellular & Molecular Immunology

Volume: 18, P: 350-362
A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity

Kuai Yu
Binyao Yang
Tangchun Wu
ResearchOpen Access26 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients

Yaguang Zhang
Xiaojing Wang
Di Wu
CorrespondenceOpen Access25 Jun 2020
Cellular & Molecular Immunology

Volume: 17, P: 878-880
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis

Xuezhen Zeng
Jingying Zhou
Alfred Sze-Lok Cheng
Research02 Sept 2020
Cellular & Molecular Immunology

Volume: 18, P: 1005-1015
Overestimated climate warming and climate variability due to spatially homogeneous CO₂ in climate modeling over the Northern Hemisphere since the mid-19^th century

Xuezhen Zhang
Xiaxiang Li
Quansheng Ge
ResearchOpen Access22 Nov 2019
Scientific Reports

Volume: 9, P: 1-9
Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells

Yun Wang
Jing Yu
Dajin Li
Research18 Jan 2010
Cellular & Molecular Immunology

Volume: 7, P: 51-60
Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing

Xiaolong Qi
Xiaoxu Chen
Bin Shen
CorrespondenceOpen Access19 Oct 2021
Cell Discovery

Volume: 7, P: 1-5
Protective humoral immunity in SARS-CoV-2 infected pediatric patients

Yaguang Zhang
Jin Xu
Bing Sun
CorrespondenceOpen Access07 May 2020
Cellular & Molecular Immunology

Volume: 17, P: 768-770

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Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress

Author Correction: The reference genome of Miscanthus floridulus illuminates the evolution of Saccharinae

Publisher Correction: The reference genome of Miscanthus floridulus illuminates the evolution of Saccharinae

The prognostic value and biological significance of MRI CE-T1-based radiomics models in CNS5-identified GBM: a multi-center study

Specificity of TGF-β1 signal designated by LRRC33 and integrin α_Vβ₈

Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis

Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease

Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

The reference genome of Miscanthus floridulus illuminates the evolution of Saccharinae

HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation

The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation

CISD3 is a prognostic biomarker and therapeutic target in pan-cancer

Sex-dependent effects of microcystin-LR on hypothalamic-pituitary-gonad axis and gametogenesis of adult zebrafish

A nomogram to predict mortality in patients with severe fever with thrombocytopenia syndrome

Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver

TMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression

TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity

A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity

Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients

Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis

Overestimated climate warming and climate variability due to spatially homogeneous CO₂ in climate modeling over the Northern Hemisphere since the mid-19^th century

Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells

Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing

Protective humoral immunity in SARS-CoV-2 infected pediatric patients

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