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Integrated optical frequency combs are powerful tools for optical spectroscopy. Here, authors demonstrate low-power, detectable-rate soliton microcombs from telecom to visible bands, including wavelength-multiplexed operation, using ultra-low-loss silicon nitride waveguides.

Proteome profiling of plasma samples in human pan-cancer cohorts reveals patterns of biomarkers for diagnosis.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

DNA Damage Regulated Autophagy Modulator 1 (DRAM1) plays pivotal roles in autophagy regulation. Here, the authors show that DRAM1 stabilizes lysosomal VAMP8, thereby promoting autolysosome maturation. Furthermore, they establish that DRAM1–VAMP8 axis enhances autophagic flux and facilitates hepatocellular carcinoma extravasation, as validated in both zebrafish xenograft and mouse metastatic models.

First-instar orchid mantis nymphs avoid predators by mimicking black-red assassin bugs, whereas those in later instars avoid predators and attract prey by camouflaging themselves as lighter-coloured flowers. Here the authors use developmental transcriptomics, evolutionary genomics and predation experiments to reveal that this ontogenetic colour change is regulated by a pigment transporter called Redboy that emerged in Polyneoptera 284–197 million years ago.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Tao et al. study the role of TRMT6 in colorectal cancer, where it is upregulated and show that TRMT6 supports histone biosynthesis by stabilizing tRNA-Lys-TTT-1-1. Targeting TRMT6 reduced histone mRNA translation in a codon-biased manner.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Near-edge plasma treatment of Hf0.5Zr0.5O2 capacitors results in dielectric permittivity of 921, stored charge density of 349 μC/cm2, and energy density of 584 J/cm3 when the material’s ferroelectricity abruptly disappears after polarization fatigue.

Electronic skin with decoupled force feedback is essential in robotics. Yan et al. develop a soft magnetic skin capable of self-decoupling three-axis forces per taxel, reducing calibration complexity from quadratic or cubic scales to a linear scale.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Trained on large and multicenter datasets with different imaging modalities, a foundation model is shown to have strong performance on the full spectrum of clinically relevant tasks and to increase user accuracy in diagnostic tasks.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

Spatiotemporal beams differ from standard spatial structured light. The authors introduce 2D spacetime duality to uncover the conventional–spatiotemporal beam connection, enabling the development of high-fidelity spatiotemporal beams.

Scanning tunnelling microscopy experiments uncover a primary pair density wave at the reconstructed surface of the kagome metal CsV₃Sb₅, and tip-assisted, atomically precise manipulation of the reconstruction provides control over the emergent quasi-two-dimensional superconductivity.

Sadhu et al. identify and functionally validate ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

The m6A reader IGF2BP3 is upregulated in various cancer, including glioblastoma. Here the authors report that IGF2BP3 facilitates NETosis and glioma survival as well as resistance to oncolytic herpes simplex virotherapy.

Human NPCs show promise for stroke treatment, but challenges remain in neuron diversity and maturation time. Here, the authors describe the generation of FOXG1 progenitors from iPSCs that quickly mature into functional cortical neurons, enhancing stroke recovery in rats.

Alpine plants exhibit phenological adaptations to germinate and complete their reproductive cycles during the most favorable growing seasons. Here, the authors show that allelic variation in the GA20ox3 gene is crucial for the adaptability of fruit length and seed germination timing in high-altitude ecotypes of A. thaliana.

Chirality has long fascinated chemists, but asymmetric synthesis has largely focused on central, axial, and helical chirality to date. Here, the authors synthesize dianthranilides with planar chirality, via cinchona alkaloid-catalyzed (dynamic) kinetic resolution.

Nuclear SREBP2 forms nuclear condensates through its N-terminal intrinsically disordered region, which is essential for the transcriptional activation of lipogenic genes.

Femtosecond polygonal optical vortices with light intensity distributions of square, pentagonal, and hexagonal shapes were generated from a passive mode-locked solid-state laser oscillator.

Several recent experimental studies have found disconnected Fermi surface arcs emerging below the Neel temperature in several rare-earth mono-pnictides. While these electronic states have been attributed to a non-collinear antiferromagnetic order, experimental evidence of this has been lacking. Here Huang et al demonstrate the emergence of non-collinear antiferromagnetic order using spin-polarized scanning tunnelling microscopy.

Band topology of Weyl semimetals is usually predetermined by material parameters and can hardly be manipulated, and their transport properties appear at low temperature. Here, the authors modify the topology via a weak magnetic field and observe a giant anomalous Hall effect at room temperature.

The design of liquid crystal networks as energy dissipation materials achieving simultaneously good mechanical and energy dissipation properties is challenging. Here, the authors fabricate energy-dissipation liquid crystal semi-interpenetrating polymer networks consisting liquid crystalline polymers with synergistic properties.

Time reflection and refraction are experimentally observed in ultracold atoms. To this end, the time boundary is formed by imposing an abrupt change in the coupling strength of the atomic chain. Time boundary effects are robust against material disorder.

Genetic resources for livestock are valuable for understanding their demography and past selection, and may inform future breeding programs and agricultural improvement. Here, the authors present deep resequencing of 248 wild and domestic sheep, with associated data and analysis.

This study presents an anionic high-entropy doping strategy, elucidating the intricate charges state regulation to drive dipole polarization-dominated dielectric loss and efficient electromagnetic wave absorption in thin graphite framework.

Digital twins can be used to support planetary operations and analysis. Here, the authors show tri-aspect characterization of lunar far side regolith and investigate the origin of a fin-shaped rock via digital twin of Yutu-2 rover.

Branched alkenyl sulfides are useful moieties in synthesis and materials. Here, the authors disclose a hydromethylthiolation of alkynes via cobalt hydride catalysis, resulting in Markovnikov regioselectivity, proceeding via electrophilic thiolation.

Preventing the strain-induced delamination between the module and the substrate has been a critical challenge. The authors developed a stretchable packaging substrate that enables stable module/substrate interfaces under large deformation, preventing the interfacial delamination of stretchable electronics.

PENSIEVE-AI is a drawing-based, digital cognitive test that can be self-administered in <5 min. It matches traditional tests in detecting cognitive impairment and dementia, offering promise for early detection in literacy-diverse populations.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

The authors showcase a method to design negative lumped elements by engineering the effective permittivity within the waveguide, which enables realizations of wideband waveguide metatronics and promises performance enhancement in various fields.

Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.