Nature Search

A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy

LYTAC strategies often face challenges in solid tumor penetration and synthesis. Here, the authors introduce Pep-TACs, a modular TFRC-based covalent peptide degradation platform that effectively degrades membrane protein PD-L1. This approach significantly suppresses both anti-PD-1-responsive and -resistant tumor growth, particularly in brain tumors.

Youmei Xiao
Zhuoying He
Yanfeng Gao
ResearchOpen Access06 Feb 2025
Nature Communications

Volume: 16, P: 1-16
Reconfigurable multi-component micromachines driven by optoelectronic tweezers

Light-driven micromotors can convert energy to motion in sub-millimeter dimensions. Here, the authors extend this concept and introduce reconfigurable micromachines with multiple components, driven by optoelectronic tweezers, and demonstrate new functionalities.

Shuailong Zhang
Mohamed Elsayed
Aaron R. Wheeler
ResearchOpen Access09 Sept 2021
Nature Communications

Volume: 12, P: 1-9
Color image encryption based on finger vein key and off-axis digital holography with phase-modulated reference light

Boyu Wang
Yanfeng Su
Yinghong Li
ResearchOpen Access25 Mar 2025
Scientific Reports

Volume: 15, P: 1-22
Impurity-healing interface engineering for efficient perovskite submodules

An impurity-healing interface engineering strategy is developed to address the issue in small-area solar cells and large-scale submodules.

Haifei Wang
Shuojian Su
Yixin Zhao
Research26 Sept 2024
Nature

Volume: 634, P: 1091-1095
A study on the relationship between the weight-adjusted waist index and kidney stone prevalence mediated by diabetes: data from NHANES 2007–2018

Yanfeng Su
Ruji Wu
Huien Pan
ResearchOpen Access31 May 2025
Scientific Reports

Volume: 15, P: 1-10
Bulk-local-density-of-state correspondence in topological insulators

Current approaches to distinguish topological phases from topologically-trivial phases have limited general applicability. Here, in a photonic-crystal context, the authors demonstrate that in trivial structures the bulk local density of states (LDOS) extends all the way to the edges and corners, while in topological structures the bulk LDOS actually avoids the edges and corners.

Biye Xie
Renwen Huang
Shuang Zhang
ResearchOpen Access14 Nov 2023
Nature Communications

Volume: 14, P: 1-8
Impact of gene-environment interactions on atrial fibrillation and cardiac structure

Panlong Li
Xirui Zhu
Dandan Tian
ResearchOpen Access15 May 2025
Scientific Reports

Volume: 15, P: 1-12
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques

The cynomolgus and Chinese rhesus macaques are used as animal models in biomedical research. Yan et al. sequence their genomes and compare the sequences to that of the Indian rhesus macaque, providing a genetic foundation for interpreting research results.

Guangmei Yan
Guojie Zhang
Jian Wang
ResearchOpen Access16 Oct 2011
Nature Biotechnology

Volume: 29, P: 1019-1023
Ultrafast charge transfer in atomically thin MoS₂/WS₂ heterostructures

The charge transfer between two layers of different two-dimensional materials occurs at a much faster speed than expected, holding promise for efficient optoelectronic devices.

Xiaoping Hong
Jonghwan Kim
Feng Wang
Research24 Aug 2014
Nature Nanotechnology

Volume: 9, P: 682-686
TNF-α-mediated m⁶A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis

Abnormal functions of mesenchymal stem cells (MSC) contribute into the pathogenensis of ankylosing spondylitis (AS). Here, the authors show that TNF-α at high concentration induces enhances migration of AS-MSC through METTL14 mediated m6A modification of the ELMO1 3′ UTR.

Zhongyu Xie
Wenhui Yu
Huiyong Shen
ResearchOpen Access10 Sept 2021
Nature Communications

Volume: 12, P: 1-14
Internally welded steel bars enhance the bonding between steel pipes and concrete and prevent disengagement and debonding

Yanfeng Deng
Haitang Zhang
Nianchun Deng
ResearchOpen Access19 Mar 2025
Scientific Reports

Volume: 15, P: 1-21
LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription

The regenerating islet-derived (REG) protein family suppresses cell death and promotes cell proliferation. Here the authors report that the lncRNA REG1CP forms an RNA–DNA triplex at the promoter of REG3A gene to increase its expression.

Hamed Yari
Lei Jin
Xu Dong Zhang
ResearchOpen Access25 Nov 2019
Nature Communications

Volume: 10, P: 1-15
Dynamic key vascular anatomy dataset for D2 lymph node dissection during laparoscopic gastric cancer surgery

Longfei Gou
Haolin Wu
Hao Chen
ResearchOpen Access29 May 2025
Scientific Data

Volume: 12, P: 1-12
Magnetism-induced topological transition in EuAs₃

Magnetic topological materials have a variety of interesting properties, but very few material realizations exist. Here, the authors report a topological nodal-line semimetal and a topological massive Dirac metal phase in EuAs₃ and demonstrate a magnetism-driven transition between these phases.

Erjian Cheng
Wei Xia
Shiyan Li
ResearchOpen Access30 Nov 2021
Nature Communications

Volume: 12, P: 1-9
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming

Xiaojun Xu
Peitao Xu
Jinteng Li
ResearchOpen Access26 Feb 2025
Cellular & Molecular Immunology

Volume: 22, P: 418-436
Single-cell RNA sequencing analysis of human bone-marrow-derived mesenchymal stem cells and functional subpopulation identification

Zhongyu Xie
Wenhui Yu
Huiyong Shen
ResearchOpen Access01 Apr 2022
Experimental & Molecular Medicine

Volume: 54, P: 483-492
A new kind of 2D topological insulators BiCN with a giant gap and its substrate effects

Botao Fu
Yanfeng Ge
Cheng-Cheng Liu
ResearchOpen Access21 Jul 2016
Scientific Reports

Volume: 6, P: 1-7
Higher-order band topology

The recent discovery of higher-order band topology in topological insulators has unveiled the hierarchical structure of topological band theory. This Perspective reviews this rapidly developing field and discusses future directions, including open challenges, future trends, synergy and its use in other fields and potential applications.

Biye Xie
Hai-Xiao Wang
Yanfeng Chen
Reviews15 Jun 2021
Nature Reviews Physics

Volume: 3, P: 520-532
Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

Yanfeng Dai
Xiang Yu
Zhihong Zhang
ResearchOpen Access16 Sept 2020
Light: Science & Applications

Volume: 9, P: 1-16
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
Observation of dimension-crossover of a tunable 1D Dirac fermion in topological semimetal NbSi_xTe₂

Jing Zhang
Yangyang Lv
Zhongkai Liu
ResearchOpen Access24 May 2022
npj Quantum Materials

Volume: 7, P: 1-7
Correction: The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA

Ming Li
Zhongyu Xie
Huiyong Shen
Amendments and CorrectionsOpen Access31 May 2024
Cell Death & Disease

Volume: 15, P: 1-3
Long intergenic non-coding RNA expression signature in human breast cancer

Yanfeng Zhang
Erin K. Wagner
Jirong Long
ResearchOpen Access29 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Perovskite light-emitting diodes based on solution-processed self-organized multiple quantum wells

Perovskite quantum wells yield highly efficient LEDs spanning the visible and near-infrared.

Nana Wang
Lu Cheng
Wei Huang
Research26 Sept 2016
Nature Photonics

Volume: 10, P: 699-704
Porous 3D graphene-based bulk materials with exceptional high surface area and excellent conductivity for supercapacitors

Long Zhang
Fan Zhang
Yongsheng Chen
ResearchOpen Access11 Mar 2013
Scientific Reports

Volume: 3, P: 1-9
Elevated TRAF4 expression impaired LPS-induced autophagy in mesenchymal stem cells from ankylosing spondylitis patients

Jinteng Li
Peng Wang
Huiyong Shen
ResearchOpen Access09 Jun 2017
Experimental & Molecular Medicine

Volume: 49, P: e343
Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma

Yongping Cui
Hongyan Chen
Zhihua Liu
Research12 May 2020
Cell Research

Volume: 30, P: 902-913
Author Correction: Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis

Wenhui Yu
Zhongyu Xie
Huiyong Shen
Amendments and CorrectionsOpen Access26 Jun 2023
Bone Research

Volume: 11, P: 1-4
Enhanced osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis: a study based on a three-dimensional biomimetic environment

Guan Zheng
Zhongyu Xie
Huiyong Shen
ResearchOpen Access25 Apr 2019
Cell Death & Disease

Volume: 10, P: 1-11
TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2

Jinteng Li
Peng Wang
Huiyong Shen
ResearchOpen Access10 May 2019
Cell Death & Differentiation

Volume: 26, P: 2652-2666
ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

Guiwen Ye
Jinteng Li
Huiyong Shen
ResearchOpen Access01 Aug 2023
Experimental & Molecular Medicine

Volume: 55, P: 1743-1756
An innovative ensemble model based on deep learning for predicting COVID-19 infection

Xiaoying Su
Yanfeng Sun
Yanan Chen
ResearchOpen Access29 Jul 2023
Scientific Reports

Volume: 13, P: 1-15
Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis

Wenhui Yu
Zhongyu Xie
Huiyong Shen
ResearchOpen Access07 Jun 2023
Bone Research

Volume: 11, P: 1-16
Gas phase multicomponent detection and analysis combining broadband dual-frequency comb absorption spectroscopy and deep learning

Libo Tian, Jinbao Xia and colleagues introduce a gas sensor that can identify the components and concentrations of gases in a mixture. This method integrates optical sensing with deep learning, providing a solution for complex gas mixture analysis.

Linbo Tian
Jinbao Xia
Sasa Zhang
ResearchOpen Access01 Aug 2023
Communications Engineering

Volume: 2, P: 1-16
Pressure-induced superconductivity and topological phase transitions in the topological nodal-line semimetal SrAs₃

Erjian Cheng
Wei Xia
Shiyan Li
ResearchOpen Access16 Jun 2020
npj Quantum Materials

Volume: 5, P: 1-8
Magnetic critical behavior of the van der Waals Fe₅GeTe₂ crystal with near room temperature ferromagnetism

Zhengxian Li
Wei Xia
Yanfeng Guo
ResearchOpen Access18 Sept 2020
Scientific Reports

Volume: 10, P: 1-10
Abnormal inhibition of osteoclastogenesis by mesenchymal stem cells through the miR-4284/CXCL5 axis in ankylosing spondylitis

Wenjie Liu
Peng Wang
Huiyong Shen
ResearchOpen Access25 Feb 2019
Cell Death & Disease

Volume: 10, P: 1-11
The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA

Ming Li
Zhongyu Xie
Huiyong Shen
ResearchOpen Access10 May 2018
Cell Death & Disease

Volume: 9, P: 1-13
Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses

Yuanxu Zhang
Yisheng Sun
Yanfeng Zhang
Research23 Mar 2022
European Journal of Human Genetics

Volume: 30, P: 922-929

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