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Realization of a gyromagnetic double-zero-index metamaterial results in unconventional optical and topological properties, suitable to be used for the generation of light pulses shaped as a vortex both in time and space.

This work demonstrates that epitaxial match at the oxide-support interfaces plays a critical role in determining whether supported metal nanoparticles oxidize from the interface or the free surface in oxygen, thereby enabling controlled oxidation.

Direct meta-selective C–H functionalization of pyridines is of paramount importance, but such reactions remain limited and highly challenging. Here, the authors report an electrochemical methodology in which nucleophilic sulfinates allow meta-sulfonylation of pyridines through a redox-neutral dearomatization-rearomatization strategy.

Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis pathway in AML cells in an RNA N⁶-Methyladenosine modification dependent manner, sensitizing AML cells to serine and glycine deprivation.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Here the authors describe oxidative C(sp3)−H amination and etherification reactions via a photoelectrochemical pathway, which directly transforms easily available hydrocarbons into N-heterocycle and ether products under mild conditions.

Chen et al. report a large-area white LED with sunlight-like emission by regulating the heterophase γ/σ-CsPb(I/Cl)₃ at nanoscale, in which a fraction of carriers recombines in γ-CsPbI₃ for deep-red emission, while other carriers diffuse to the heterophase interface for broadband emission.

STING agonist-based endoplasmic reticulum-targeting molecules can be conjugated directly onto antigens to deliver them to the cross-presentation pathway, improving CD8⁺ T cell responses against tumours and viruses.

Diethyl ethylphosphonate (DEEP) is a promising candidate for developing non- flammable electrolytes for wide-temperature application in Li-ion batteries, but low compatibility with graphite electrodes and slow ionic transport hinder its implementation. Here, the authors show that incorporating diethylene glycol dimethyl ether into a DEEP-based electrolyte enhances ion transport and improves low-temperature performance in graphite-based cells.

Hemostatic failure and the risk of rebleeding present significant challenges. Here, Chen et al. design a covalently reactive hemostat based on blood-imbibing and -crosslinking microparticles, achieving rapid hemostasis and preventing rebleeding.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Cholesterol metabolism is altered in amyotrophic lateral sclerosis. The authors show that promoting cellular cholesterol excretion in a mouse model improves myelination, reduces the disease-associated oligodendrocyte response, and prolongs survival.

Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

The molecular mechanisms of astroblastoma development are identified, whereby distinct gene fusions upregulate shared transcriptional networks to disrupt the normal development of ventral telencephalon neural progenitors, which leads to oncogenesis.

Oral drug delivery system has clinical potential for colorectal cancer (CRC) drug therapy but limited by the delivery efficiency when transporting through the formidable intestinal barriers. Here this group reports a Lactobacillus rhamnosus-engineered mesoporous silica nanosystem which effectively penetrates intestinal mucus and epithelial barrier, thereby delivering NO donor BNN6 and cisplatin for in vivo CRC tumor growth inhibition.

Cerebrospinal fluid circulating tumor DNA profiling had prognostic value in a cohort of 584 patients with lung cancer and central nervous system metastases, and could be used to inform personalized therapies.

The position of hydroxyl groups, the carbon number of the alkyl chain, and the modification of the side chain are key factors determining the function of diols. Here, the authors report a biosynthetic platform in Escherichia coli for the synthesis of branched-chain β,γ-diols from renewable feedstocks.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.

Reusable and degradable thermoset polymers are prepared by dynamic covalent chemistry, but the dynamic bonds rarely provide additional functions to the materials. Here, the authors show a reversible aza-Michael addition reaction between functional heterocycle dihydropyrimidin-2(1H)-thione and electron-deficient olefins providing polymer structures with different functions.

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses in temporary cardiac pacing.

Ultrahigh electromechanical response is accomplished by inducing extreme structural instability from competing antiferroelectric and ferroelectric orders.

Li et al. report the sublattice decoupling in Rb₆Re₆S₈I₈ upon compression, in which [Rb₆I₂]⁴⁺ framework can be selectively amorphized while the [Re₆S₈I₆]^4- clusters keep in ordered state, leading to emission-to-photocurrent switching at 15 GPa, which can retain when back to ambient condition.

The uneven surfaces of copper indium gallium selenide (CIGS) solar cells pose challenges for depositing the upper layers in flexible perovskite/CIGS tandem solar cells. Ying et al. tackle this issue using an antisolvent and seeding strategy, resulting in a certified efficiency of 23.8%.

Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the authors show that TIGIT limits the differentiation of inflammatory Th1 and Th17 cells via a metabolic-epigenetic mechanism, which involves the inhibition of CD28-mediated PI3K/AKT/mTOR costimulatory signaling.

Yang, Jn-Simon, He et al. report that the dual BCL-xL/BCL-2 PROTAC 753b is a potent and liver-tropic senolytic, which (unlike other inhibitors of BCL-xL) does not cause severe thrombocytopenia. They evaluate its efficacy in natural aging and in reducing progression from steatotic liver disease to hepatocellular carcinoma, using mouse models.

The African swine fever virus represents a threat to global pig production. Here, the authors determine the cryo-EM structures of ASFV RNA polymerase, and suggest that the M1249L subunit may modulate polymerase activity in cells.

The anomalous Hall angle parameter tanθ^A can be formulated as a function of the product of electrical resistivity and anomalous Hall conductivity, a scheme that allows the anomalous Hall angle in the magnetic Weyl semimetal Co₃Sn₂S₂ to be increased to 25°.

Observations of γ-rays with energies up to 1.4 PeV find that 12 sources in the Galaxy are PeVatrons, one of which is the Crab Nebula.

This study reveals that E. coli lipoate-protein ligase A (LplA) exhibits reversible phase separation and forms condensates in cells, which can be specifically regulated by small molecules, offering chemical tools for synthetic biology and biomedicine.

Molecular tools enabling precise DNA mutations and targeted modulation of gene expression have significant potential in medicine and biology. Here, the authors develop a compact system for simultaneous and independent gene editing, activation, and repression in mammalian cells.

This large study, conducted in school-aged children in China, evaluates the relationship between long-term exposure to ambient particulate matter and positive screening for attention deficit hyperactivity disorder (ADHD). The authors report stronger associations between ADHD and PM₁ exposure than between ADHD and PM_2.5.